Immune-correlates analysis of an HIV-1 vaccine efficacy trial reveals an association of nonspecific interferon-γ secretion with increased HIV-1 infection risk: a cohort-based model...

by Yunda Huang, Ann Duerr, Nicole Frahm, Lily Zhang, Zoe Moodie, Steve De Rosa, M Juliana McElrath, Peter B Gilbert
Published 2014-01-01

Pre-existing adenovirus immunity modifies a complex mixed Th1 and Th2 cytokine response to an Ad5/HIV-1 vaccine candidate in humans.

by Samuel O Pine, James G Kublin, Scott M Hammer, Joleen Borgerding, Yunda Huang, Danilo R Casimiro, M Juliana McElrath
Published 2011-04-01

Cell-Mediated Immune Predictors of Vaccine Effect on Viral Load and CD4 Count in a Phase 2 Therapeutic HIV-1 Vaccine Clinical Trial

by Yunda Huang, Giuseppe Pantaleo, Gonzalo Tapia, Brittany Sanchez, Lily Zhang, Monica Trondsen, Arnt-Ove Hovden, Richard Pollard, Jürgen Rockstroh, Mats Ökvist, Maja A. Sommerfelt
Published 2017-10-01

Early Pro-Inflammatory Signal and T-Cell Activation Associate With Vaccine-Induced Anti-Vaccinia Protective Neutralizing Antibodies

by Jue Hou, Shuhui Wang, Dan Li, Lindsay N. Carpp, Tong Zhang, Ying Liu, Manxue Jia, Hong Peng, Chang Liu, Hao Wu, Yunda Huang, Yiming Shao
Published 2021-10-01

Therapeutic prediction of HIV-1 DNA decay: a multicenter longitudinal cohort study

by Yongsong Yue, Yijia Li, Yizhi Cui, Nidan Wang, Yunda Huang, Wei Cao, Yang Han, Ting Zhu, Wei Lyu, Jing Xie, Xiaojing Song, Yanling Li, Tong Wang, Tuofu Zhu, Taisheng Li
Published 2021-06-01

A mixed methods investigation of implementation barriers and facilitators to a daily mobile phone sexual risk assessment for young women in Soweto, South Africa.

by Janan J Dietrich, Stefanie Hornschuh, Mamakiri Khunwane, Lerato M Makhale, Kennedy Otwombe, Cecilia Morgan, Yunda Huang, Maria Lemos, Erica Lazarus, James G Kublin, Glenda E Gray, Fatima Laher, Michele Andrasik, HVTN 915 team
Published 2020-01-01

In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide.

by Lisa C Rohan, Bernard J Moncla, Ratiya Pamela Kunjara Na Ayudhya, Marilyn Cost, Yunda Huang, Fang Gai, Nicole Billitto, J D Lynam, Kara Pryke, Phillip Graebing, Nicole Hopkins, James F Rooney, David Friend, Charlene S Dezzutti
Published 2010-02-01

Mathematical modeling to reveal breakthrough mechanisms in the HIV Antibody Mediated Prevention (AMP) trials.

by Daniel B Reeves, Yunda Huang, Elizabeth R Duke, Bryan T Mayer, E Fabian Cardozo-Ojeda, Florencia A Boshier, David A Swan, Morgane Rolland, Merlin L Robb, John R Mascola, Myron S Cohen, Lawrence Corey, Peter B Gilbert, Joshua T Schiffer
Published 2020-02-01

Pharmacokinetics and predicted neutralisation coverage of VRC01 in HIV-uninfected participants of the Antibody Mediated Prevention (AMP) trials

by Yunda Huang, Logashvari Naidoo, Lily Zhang, Lindsay N. Carpp, Erika Rudnicki, April Randhawa, Pedro Gonzales, Adrian McDermott, Julie Ledgerwood, Margarita M.Gomez Lorenzo, David Burns, Allan DeCamp, Michal Juraska, John Mascola, Srilatha Edupuganti, Nyaradzo Mgodi, Myron Cohen, Lawrence Corey, Philip Andrew, Shelly Karuna, Peter B. Gilbert, Kathryn Mngadi, Erica Lazarus
Published 2021-02-01

Equivalence of ELISpot assays demonstrated between major HIV network laboratories.

by Dilbinder K Gill, Yunda Huang, Gail L Levine, Anna Sambor, Donald K Carter, Alicia Sato, Jakub Kopycinski, Peter Hayes, Bridget Hahn, Josephine Birungi, Tony Tarragona-Fiol, Hong Wan, Mark Randles, Andrew Raxworthy Cooper, Aloysius Ssemaganda, Lorna Clark, Pontiano Kaleebu, Steven G Self, Richard Koup, Blake Wood, M Juliana McElrath, Josephine H Cox, John Hural, Jill Gilmour
Published 2010-12-01

Immunogenicity of a novel Clade B HIV-1 vaccine combination: Results of phase 1 randomized placebo controlled trial of an HIV-1 GM-CSF-expressing DNA prime with a modified vaccinia...

by Susan P Buchbinder, Nicole A Grunenberg, Brittany J Sanchez, Kelly E Seaton, Guido Ferrari, M Anthony Moody, Nicole Frahm, David C Montefiori, Christine M Hay, Paul A Goepfert, Lindsey R Baden, Harriet L Robinson, Xuesong Yu, Peter B Gilbert, M Juliana McElrath, Yunda Huang, Georgia D Tomaras, HIV Vaccine Trials Network (HVTN) 094 Study Group
Published 2017-01-01

Effect of rAd5-Vector HIV-1 Preventive Vaccines on HIV-1 Acquisition: A Participant-Level Meta-Analysis of Randomized Trials.

by Yunda Huang, Dean Follmann, Martha Nason, Lily Zhang, Ying Huang, Devan V Mehrotra, Zoe Moodie, Barbara Metch, Holly Janes, Michael C Keefer, Gavin Churchyard, Merlin L Robb, Patricia E Fast, Ann Duerr, M Juliana McElrath, Lawrence Corey, John R Mascola, Barney S Graham, Magdalena E Sobieszczyk, James G Kublin, Michael Robertson, Scott M Hammer, Glenda E Gray, Susan P Buchbinder, Peter B Gilbert
Published 2015-01-01

Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adult...

by Kenneth H Mayer, Kelly E Seaton, Yunda Huang, Nicole Grunenberg, Abby Isaacs, Mary Allen, Julie E Ledgerwood, Ian Frank, Magdalena E Sobieszczyk, Lindsey R Baden, Benigno Rodriguez, Hong Van Tieu, Georgia D Tomaras, Aaron Deal, Derrick Goodman, Robert T Bailer, Guido Ferrari, Ryan Jensen, John Hural, Barney S Graham, John R Mascola, Lawrence Corey, David C Montefiori, HVTN 104 Protocol Team, and the NIAID HIV Vaccine Trials Network
Published 2017-11-01

Intramuscular and Intradermal Electroporation of HIV-1 PENNVAX-GP^® DNA Vaccine and IL-12 Is Safe, Tolerable, Acceptable in Healthy Adults

by Srilatha Edupuganti, Stephen C. De Rosa, Marnie Elizaga, Yiwen Lu, Xue Han, Yunda Huang, Edith Swann, Laura Polakowski, Spyros A. Kalams, Michael Keefer, Janine Maenza, Megan C. Wise, Jian Yan, Matthew P. Morrow, Amir S. Khan, Jean D. Boyer, Laurent Humeau, Scott White, Niranjan Y. Sardesai, Mark L. Bagarazzi, Peter B. Gilbert, James G. Kublin, Lawrence Corey, David B. Weiner, on behalf of the HVTN 098 Study Team, the NIAID-Funded HIV Vaccine Trials Network
Published 2020-12-01

Combining Viral Genetics and Statistical Modeling to Improve HIV-1 Time-of-infection Estimation towards Enhanced Vaccine Efficacy Assessment

by Raabya Rossenkhan, Morgane Rolland, Jan P.L. Labuschagne, Roux-Cil Ferreira, Craig A. Magaret, Lindsay N. Carpp, Frederick A. Matsen IV, Yunda Huang, Erika E. Rudnicki, Yuanyuan Zhang, Nonkululeko Ndabambi, Murray Logan, Ted Holzman, Melissa-Rose Abrahams, Colin Anthony, Sodsai Tovanabutra, Christopher Warth, Gordon Botha, David Matten, Sorachai Nitayaphan, Hannah Kibuuka, Fred K. Sawe, Denis Chopera, Leigh Anne Eller, Simon Travers, Merlin L. Robb, Carolyn Williamson, Peter B. Gilbert, Paul T. Edlefsen
Published 2019-07-01

Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans

by Kelly E. Seaton, Aaron Deal, Xue Han, Shuying S. Li, Ashley Clayton, Jack Heptinstall, Ann Duerr, Mary A. Allen, Xiaoying Shen, Sheetal Sawant, Nicole L. Yates, Paul Spearman, Gavin Churchyard, Paul A. Goepfert, Janine Maenza, Glenda Gray, Giuseppe Pantaleo, Laura Polakowski, Harriet L. Robinson, Shannon Grant, April K. Randhawa, Ying Huang, Cecilia Morgan, Nicole Grunenberg, Shelly Karuna, Peter B. Gilbert, M. Juliana McElrath, Yunda Huang, Georgia D. Tomaras, NIAID HIV Vaccine Trials Network (HVTN) 076, 088, 086, 096, 097, 205 Study Teams
Published 2021-04-01