A synDNA vaccine delivering neoAg collections controls heterogenous, multifocal murine lung and ovarian tumors via robust T cell generation

by Pratik S. Bhojnagarwala, Alfredo Perales-Puchalt, Neil Cooch, Niranjan Y. Sardesai, David B. Weiner
Published 2021-06-01

Optimized In Vivo Transfer of Small Interfering RNA Targeting Dermal Tissue Using In Vivo Surface Electroporation

by Kate E Broderick, Amy Chan, Feng Lin, Xuefei Shen, Gleb Kichaev, Amir S Khan, Justin Aubin, Tracy S Zimmermann, Niranjan Y. Sardesai
Published 2012-01-01

Enhanced Delivery and Potency of Self-Amplifying mRNA Vaccines by Electroporation in Situ

by Kaustuv Banerjee, Julie Hickman, Andrew Geall, Jeffrey B. Ulmer, Gleb Kichaev, Niranjan Y. Sardesai, Yen Cu, Susan Barnett, Gillis Otten, Kate E. Broderick
Published 2013-08-01

Elucidating the Kinetics of Expression and Immune Cell Infiltration Resulting from Plasmid Gene Delivery Enhanced by Surface Dermal Electroporation

by Kate E. Broderick, Niranjan Y. Sardesai, Trevor R. F. Smith, William B. Kiosses, Christine L. Knott, Gleb Kichaev, Dinah H. Amante, Janess M. Mendoza
Published 2013-08-01

Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens.

by Dominick J Laddy, Jian Yan, Michele Kutzler, Darwyn Kobasa, Gary P Kobinger, Amir S Khan, Jack Greenhouse, Niranjan Y Sardesai, Ruxandra Draghia-Akli, David B Weiner
Published 2008-01-01

DNA vaccination strategy targets epidermal dendritic cells, initiating their migration and induction of a host immune response

by Trevor RF Smith, Katherine Schultheis, William B Kiosses, Dinah H Amante, Janess M Mendoza, John C Stone, Jay R McCoy, Niranjan Y Sardesai, Kate E Broderick
Published 2014-01-01

Enhanced Efficacy of a Codon-Optimized DNA Vaccine Encoding the Glycoprotein Precursor Gene of Lassa Virus in a Guinea Pig Disease Model When Delivered by Dermal Electroporation

by Niranjan Y. Sardesai, Connie S. Schmaljohn, Catherine V. Badger, Mary C. Guttieri, Kristin W. Spik, Carl I. Shaia, Amy C. Shurtleff, Todd M. Bell, Kate E. Broderick, Eric R. Wilkinson, Kathleen A. Cashman
Published 2013-07-01

HIV-1 Env DNA vaccine plus protein boost delivered by EP expands B- and T-cell responses and neutralizing phenotype in vivo.

by Kar Muthumani, Megan C Wise, Kate E Broderick, Natalie Hutnick, Jonathan Goodman, Seleeke Flingai, Jian Yan, Chaoran B Bian, Janess Mendoza, Colleen Tingey, Christine Wilson, Krzysztof Wojtak, Niranjan Y Sardesai, David B Weiner
Published 2013-01-01

Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.

by Viraj Kulkarni, Antonio Valentin, Margherita Rosati, Candido Alicea, Ashish K Singh, Rashmi Jalah, Kate E Broderick, Niranjan Y Sardesai, Sylvie Le Gall, Beatriz Mothe, Christian Brander, Morgane Rolland, James I Mullins, George N Pavlakis, Barbara K Felber
Published 2014-01-01

A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates.

by Karthik Mallilankaraman, Devon J Shedlock, Huihui Bao, Omkar U Kawalekar, Paolo Fagone, Aarthi A Ramanathan, Bernadette Ferraro, Jennifer Stabenow, Paluru Vijayachari, Senthil G Sundaram, Nagarajan Muruganandam, Gopalsamy Sarangan, Padma Srikanth, Amir S Khan, Mark G Lewis, J Joseph Kim, Niranjan Y Sardesai, Karuppiah Muthumani, David B Weiner
Published 2011-01-01

Augmentation of cellular and humoral immune responses to HPV16 and HPV18 E6 and E7 antigens by VGX-3100

by Matthew P Morrow, Kimberly A Kraynyak, Albert J Sylvester, Xuefei Shen, Dinah Amante, Lindsay Sakata, Lamar Parker, Jian Yan, Jean Boyer, Christian Roh, Laurent Humeau, Amir S Khan, Kate Broderick, Kathleen Marcozzi-Pierce, Mary Giffear, Jessica Lee, Cornelia L Trimble, J Joseph Kim, Niranjan Y Sardesai, David B Weiner, Mark L Bagarazzi
Published 2016-01-01

HIV-1 p24(gag) derived conserved element DNA vaccine increases the breadth of immune response in mice.

by Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Brunda Ganneru, Ashish K Singh, Jian Yan, Morgane Rolland, Candido Alicea, Rachel Kelly Beach, Gen-Mu Zhang, Sylvie Le Gall, Kate E Broderick, Niranjan Y Sardesai, David Heckerman, Beatriz Mothe, Christian Brander, David B Weiner, James I Mullins, George N Pavlakis, Barbara K Felber
Published 2013-01-01

DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections

by Sarah T. C. Elliott, Nicole L. Kallewaard, Ebony Benjamin, Leslie Wachter-Rosati, Josephine M. McAuliffe, Ami Patel, Trevor R. F. Smith, Katherine Schultheis, Daniel H. Park, Seleeke Flingai, Megan C. Wise, Janess Mendoza, Stephanie Ramos, Kate E. Broderick, Jian Yan, Laurent M. Humeau, Niranjan Y. Sardesai, Kar Muthumani, Qing Zhu, David B. Weiner
Published 2017-07-01

DNA and protein co-immunization improves the magnitude and longevity of humoral immune responses in macaques.

by Rashmi Jalah, Viraj Kulkarni, Vainav Patel, Margherita Rosati, Candido Alicea, Jenifer Bear, Lei Yu, Yongjun Guan, Xiaoying Shen, Georgia D Tomaras, Celia LaBranche, David C Montefiori, Rajasekhar Prattipati, Abraham Pinter, Julian Bess, Jeffrey D Lifson, Steven G Reed, Niranjan Y Sardesai, David J Venzon, Antonio Valentin, George N Pavlakis, Barbara K Felber
Published 2014-01-01

An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model

by Ami Patel, Antonio DiGiandomenico, Ashley E. Keller, Trevor R. F. Smith, Daniel H. Park, Stephanie Ramos, Katherine Schultheis, Sarah T. C. Elliott, Janess Mendoza, Kate E. Broderick, Megan C. Wise, Jian Yan, Jingjing Jiang, Seleeke Flingai, Amir S. Khan, Kar Muthumani, Laurent Humeau, Lily I. Cheng, Leslie Wachter-Rosati, C. Kendall Stover, Niranjan Y. Sardesai, David B. Weiner
Published 2017-09-01

Intramuscular and Intradermal Electroporation of HIV-1 PENNVAX-GP^® DNA Vaccine and IL-12 Is Safe, Tolerable, Acceptable in Healthy Adults

by Srilatha Edupuganti, Stephen C. De Rosa, Marnie Elizaga, Yiwen Lu, Xue Han, Yunda Huang, Edith Swann, Laura Polakowski, Spyros A. Kalams, Michael Keefer, Janine Maenza, Megan C. Wise, Jian Yan, Matthew P. Morrow, Amir S. Khan, Jean D. Boyer, Laurent Humeau, Scott White, Niranjan Y. Sardesai, Mark L. Bagarazzi, Peter B. Gilbert, James G. Kublin, Lawrence Corey, David B. Weiner, on behalf of the HVTN 098 Study Team, the NIAID-Funded HIV Vaccine Trials Network
Published 2020-12-01

In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model

by Ami Patel, Daniel H. Park, Carl W. Davis, Trevor R.F. Smith, Anders Leung, Kevin Tierney, Aubrey Bryan, Edgar Davidson, Xiaoying Yu, Trina Racine, Charles Reed, Marguerite E. Gorman, Megan C. Wise, Sarah T.C. Elliott, Rianne Esquivel, Jian Yan, Jing Chen, Kar Muthumani, Benjamin J. Doranz, Erica Ollmann Saphire, James E. Crowe, Kate E. Broderick, Gary P. Kobinger, Shihua He, Xiangguo Qiu, Darwyn Kobasa, Laurent Humeau, Niranjan Y. Sardesai, Rafi Ahmed, David B. Weiner
Published 2018-11-01

DNA vaccination protects mice against Zika virus-induced damage to the testes

by Bryan D. Griffin, Kar Muthumani, Bryce M. Warner, Anna Majer, Mable Hagan, Jonathan Audet, Derek R. Stein, Charlene Ranadheera, Trina Racine, Marc-Antoine De La Vega, Jocelyne Piret, Stephanie Kucas, Kaylie N. Tran, Kathy L. Frost, Christine De Graff, Geoff Soule, Leanne Scharikow, Jennifer Scott, Gordon McTavish, Valerie Smid, Young K. Park, Joel N. Maslow, Niranjan Y. Sardesai, J. Joseph Kim, Xiao-jian Yao, Alexander Bello, Robbin Lindsay, Guy Boivin, Stephanie A. Booth, Darwyn Kobasa, Carissa Embury-Hyatt, David Safronetz, David B. Weiner, Gary P. Kobinger
Published 2017-06-01