Development of a target identification approach using native mass spectrometry

by Miaomiao Liu, Wesley C. Van Voorhis, Ronald J. Quinn
Published 2021-01-01

An essential farnesylated kinesin in Trypanosoma brucei.

by Erin J Engelson, Frederick S Buckner, Wesley C Van Voorhis
Published 2011-01-01

Thematic review series: Lipid Posttranslational Modifications. Fighting parasitic disease by blocking protein farnesylation

by Richard T. Eastman, Frederick S. Buckner, Kohei Yokoyama, Michael H. Gelb, Wesley C. Van Voorhis
Published 2006-02-01

The role of medical structural genomics in discovering new drugs for infectious diseases.

by Wesley C Van Voorhis, Wim G J Hol, Peter J Myler, Lance J Stewart
Published 2009-10-01

Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G

by Abhisheka Bansal, Kayode K. Ojo, Jianbing Mu, Dustin J. Maly, Wesley C. Van Voorhis, Louis H. Miller
Published 2016-12-01

Evaluating the safety, tolerability, pharmacokinetics and efficacy of clofazimine in cryptosporidiosis (CRYPTOFAZ): study protocol for a randomized controlled trial

by Patrick Nachipo, David Hermann, Gerald Quinnan, Melita A. Gordon, Wesley C. Van Voorhis, Pui-Ying Iroh Tam
Published 2018-08-01

Stabilizing additives added during cell lysis aid in the solubilization of recombinant proteins.

by David J Leibly, Trang Nhu Nguyen, Louis T Kao, Stephen N Hewitt, Lynn K Barrett, Wesley C Van Voorhis
Published 2012-01-01

The Impact of BKI-1294 Therapy in Mice Infected With the Apicomplexan Parasite Neospora caninum and Re-infected During Pregnancy

by Pablo Winzer, Pablo Winzer, Dennis Imhof, Dennis Imhof, Nicoleta Anghel, Nicoleta Anghel, Dominic Ritler, Dominic Ritler, Joachim Müller, Ghalia Boubaker, Adriana Aguado-Martinez, Luis-Miguel Ortega-Mora, Kayode K. Ojo, Wesley C. VanVoorhis, Wesley C. VanVoorhis, Andrew Hemphill
Published 2020-10-01

<i>Neospora caninum</i>: Structure and Fate of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294

by Pablo Winzer, Nicoleta Anghel, Dennis Imhof, Vreni Balmer, Luis-Miguel Ortega-Mora, Kayode K. Ojo, Wesley C. Van Voorhis, Joachim Müller, Andrew Hemphill
Published 2020-05-01

Reduced treatment frequencies with bumped kinase inhibitor 1369 are effective against porcine cystoisosporosis

by Aruna Shrestha, Bärbel Ruttkowski, Patricia Greber, Grant R. Whitman, Matthew A. Hulverson, Ryan Choi, Samantha A. Michaels, Kayode K. Ojo, Wesley C. Van Voorhis, Anja Joachim
Published 2020-12-01

Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission

by Ryan Choi, Samantha A. Michaels, Emmanuel C. Onu, Matthew A. Hulverson, Aparajita Saha, Morenike E. Coker, Janis C. Weeks, Wesley C. Van Voorhis, Kayode K. Ojo
Published 2020-06-01

Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads.

by Richard O Oduor, Kayode K Ojo, Gareth P Williams, Francois Bertelli, James Mills, Louis Maes, David C Pryde, Tanya Parkinson, Wesley C Van Voorhis, Tod P Holler
Published 2011-04-01

<i>Neospora caninum</i>: Differential Proteome of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294

by Pablo Winzer, Joachim Müller, Dennis Imhof, Dominic Ritler, Anne-Christine Uldry, Sophie Braga-Lagache, Manfred Heller, Kayode K. Ojo, Wesley C. Van Voorhis, Luis-Miguel Ortega-Mora, Andrew Hemphill
Published 2020-05-01

Identification of attractive drug targets in neglected-disease pathogens using an in silico approach.

by Gregory J Crowther, Dhanasekaran Shanmugam, Santiago J Carmona, Maria A Doyle, Christiane Hertz-Fowler, Matthew Berriman, Solomon Nwaka, Stuart A Ralph, David S Roos, Wesley C Van Voorhis, Fernán Agüero
Published 2010-01-01

Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms

by Spencer O. Moen, Thomas E. Edwards, David M. Dranow, Matthew C. Clifton, Banumathi Sankaran, Wesley C. Van Voorhis, Amit Sharma, Colin Manoil, Bart L. Staker, Peter J. Myler, Donald D. Lorimer
Published 2017-03-01

Conducting clinical trials in sub-Saharan Africa: challenges and lessons learned from the Malawi Cryptosporidium study

by Neema Toto, Elaine Douglas, Markus Gmeiner, Lynn K. Barrett, Robert Lindblad, Lumbani Makhaza, Wilfred Nedi, Jacob Phulusa, Gerald V. Quinnan, Leigh A. Sawyer, Herbert Thole, Wesley C. Van Voorhis, Pui-Ying Iroh Tam
Published 2020-07-01

Recombinant human G6PD for quality control and quality assurance of novel point-of-care diagnostics for G6PD deficiency.

by Maria Kahn, Nicole LaRue, Changcheng Zhu, Sampa Pal, Jack S Mo, Lynn K Barrett, Steve N Hewitt, Mitchell Dumais, Sandra Hemmington, Adrian Walker, Jeff Joynson, Brandon T Leader, Wesley C Van Voorhis, Gonzalo J Domingo
Published 2017-01-01

In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzo...

by Dennis Imhof, Nicoleta Anghel, Pablo Winzer, Vreni Balmer, Jessica Ramseier, Kai Hänggeli, Ryan Choi, Matthew A. Hulverson, Grant R. Whitman, Samuel L.M. Arnold, Kayode K. Ojo, Wesley C. Van Voorhis, J. Stone Doggett, Luis M. Ortega-Mora, Andrew Hemphill
Published 2021-08-01

Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screens.

by Gregory J Crowther, Michael L Booker, Min He, Ting Li, Sylvine Raverdy, Jacopo F Novelli, Panqing He, Natalie R G Dale, Amy M Fife, Robert H Barker, Martin L Kramer, Wesley C Van Voorhis, Clotilde K S Carlow, Ming-Wei Wang
Published 2014-01-01

Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy.

by Kayode K Ojo, Molly C Reid, Latha Kallur Siddaramaiah, Joachim Müller, Pablo Winzer, Zhongsheng Zhang, Katelyn R Keyloun, Rama Subba Rao Vidadala, Ethan A Merritt, Wim G J Hol, Dustin J Maly, Erkang Fan, Wesley C Van Voorhis, Andrew Hemphill
Published 2014-01-01