Synthesis and Antiparasitic Activity of New Conjugates—Organic Drugs Tethered to Trithiolato-Bridged Dinuclear Ruthenium(II)–Arene Complexes

by Oksana Desiatkina, Serena K. Johns, Nicoleta Anghel, Ghalia Boubaker, Andrew Hemphill, Julien Furrer, Emilia Păunescu
Published 2021-07-01

The Impact of BKI-1294 Therapy in Mice Infected With the Apicomplexan Parasite Neospora caninum and Re-infected During Pregnancy

by Pablo Winzer, Pablo Winzer, Dennis Imhof, Dennis Imhof, Nicoleta Anghel, Nicoleta Anghel, Dominic Ritler, Dominic Ritler, Joachim Müller, Ghalia Boubaker, Adriana Aguado-Martinez, Luis-Miguel Ortega-Mora, Kayode K. Ojo, Wesley C. VanVoorhis, Wesley C. VanVoorhis, Andrew Hemphill
Published 2020-10-01

<i>Neospora caninum</i>: Structure and Fate of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294

by Pablo Winzer, Nicoleta Anghel, Dennis Imhof, Vreni Balmer, Luis-Miguel Ortega-Mora, Kayode K. Ojo, Wesley C. Van Voorhis, Joachim Müller, Andrew Hemphill
Published 2020-05-01

Endochin-Like Quinolones Exhibit Promising Efficacy Against Neospora Caninum in vitro and in Experimentally Infected Pregnant Mice

by Nicoleta Anghel, Vreni Balmer, Joachim Müller, Pablo Winzer, Adriana Aguado-Martinez, Mona Roozbehani, Sovitj Pou, Aaron Nilsen, Michael Riscoe, J. Stone Doggett, Andrew Hemphill
Published 2018-11-01

Conjugates Containing Two and Three Trithiolato-Bridged Dinuclear Ruthenium(II)-Arene Units as In Vitro Antiparasitic and Anticancer Agents

by Valentin Studer, Nicoleta Anghel, Oksana Desiatkina, Timo Felder, Ghalia Boubaker, Yosra Amdouni, Jessica Ramseier, Martin Hungerbühler, Christoph Kempf, Johannes Thomas Heverhagen, Andrew Hemphill, Nico Ruprecht, Julien Furrer, Emilia Păunescu
Published 2020-12-01

A novel experimental approach to evaluate guided bone regeneration (GBR) in the rat femur using a 3D-printed CAD/CAM zirconia space-maintaining barrier

by Alexandru Petre, Cornel Balta, Hildegard Herman, Sami Gharbia, Ada Codreanu, Bianca Onita-Mladin, Nicoleta Anghel-Zurbau, Andrei-Gelu Hermenean, Simona-Rebeca Ignat, Sorina Dinescu, Iuliana Urzica, Sergiu Drafta, Luminita Oancea, Anca Hermenean
Published 2021-02-01

In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzo...

by Dennis Imhof, Nicoleta Anghel, Pablo Winzer, Vreni Balmer, Jessica Ramseier, Kai Hänggeli, Ryan Choi, Matthew A. Hulverson, Grant R. Whitman, Samuel L.M. Arnold, Kayode K. Ojo, Wesley C. Van Voorhis, J. Stone Doggett, Luis M. Ortega-Mora, Andrew Hemphill
Published 2021-08-01

Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo

by Nicoleta Anghel, Dennis Imhof, Pablo Winzer, Vreni Balmer, Jessica Ramseier, Kai Haenggeli, Ryan Choi, Matthew A. Hulverson, Grant R. Whitman, Samuel L.M. Arnold, Kayode K. Ojo, Wesley C. Van Voorhis, J. Stone Doggett, Luis M. Ortega-Mora, Andrew Hemphill
Published 2021-12-01