Precursor Structure of Cephalosporin Acylase: Insights into Auto-Proteolytic Activation in a New N-Terminal Hydrolase Family

by Youngsoo Kim, Sanggu Kim, Thomas N. Earnest, Wim G.J. Hol
Published 2002-01-01

The role of medical structural genomics in discovering new drugs for infectious diseases.

by Wesley C Van Voorhis, Wim G J Hol, Peter J Myler, Lance J Stewart
Published 2009-10-01

Structural and functional studies on the interaction of GspC and GspD in the type II secretion system.

by Konstantin V Korotkov, Tanya L Johnson, Michael G Jobling, Jonathan Pruneda, Els Pardon, Annie Héroux, Stewart Turley, Jan Steyaert, Randall K Holmes, Maria Sandkvist, Wim G J Hol
Published 2011-09-01

Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness.

by Cho Yeow Koh, Jessica E Kim, Allan B Wetzel, Will J de van der Schueren, Sayaka Shibata, Ranae M Ranade, Jiyun Liu, Zhongsheng Zhang, J Robert Gillespie, Frederick S Buckner, Christophe L M J Verlinde, Erkang Fan, Wim G J Hol
Published 2014-04-01

Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy.

by Kayode K Ojo, Molly C Reid, Latha Kallur Siddaramaiah, Joachim Müller, Pablo Winzer, Zhongsheng Zhang, Katelyn R Keyloun, Rama Subba Rao Vidadala, Ethan A Merritt, Wim G J Hol, Dustin J Maly, Erkang Fan, Wesley C Van Voorhis, Andrew Hemphill
Published 2014-01-01