A Simple Method for Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation of Key Principles from Heparin/Heparan Sulfate-Binding Proteins.

by Aurijit Sarkar, Umesh R Desai
Published 2015-01-01

Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8

by Shravan Morla, Umesh R. Desai
Published 2020-08-01

Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2–Chondroitin Sulfate System

by Nehru Viji Sankaranarayanan, Balaji Nagarajan, Umesh R. Desai
Published 2021-07-01

Structural Insights Into How Proteoglycans Determine Chemokine-CXCR1/CXCR2 Interactions: Progress and Challenges

by Krishna Rajarathnam, Krishna Rajarathnam, Krishna Rajarathnam, Umesh R. Desai
Published 2020-04-01

Combinatorial virtual library screening analysis of antithrombin binding oligosaccharide motif generation by heparan sulfate 3-O-Sulfotransferase 1

by Nehru Viji Sankaranarayanan, Yiling Bi, Balagurunathan Kuberan, Umesh R. Desai
Published 2020-01-01

A molecular dynamics-based algorithm for evaluating the glycosaminoglycan mimicking potential of synthetic, homogenous, sulfated small molecules.

by Balaji Nagarajan, Nehru Viji Sankaranarayanan, Bhaumik B Patel, Umesh R Desai
Published 2017-01-01

Plasmin Regulation through Allosteric, Sulfated, Small Molecules

by Rami A. Al-Horani, Rajesh Karuturi, Domonique T. White, Umesh R. Desai
Published 2015-01-01

On the specificity of heparin/heparan sulfate binding to proteins. Anion-binding sites on antithrombin and thrombin are fundamentally different.

by Philip D Mosier, Chandravel Krishnasamy, Glen E Kellogg, Umesh R Desai
Published 2012-01-01

6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells.

by Xing Wang, Zhiwei Wang, Preetpal Singh Sidhu, Umesh R Desai, Qibing Zhou
Published 2015-01-01

Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile.

by Rami A Al-Horani, Rajesh Karuturi, Michael Lee, Daniel K Afosah, Umesh R Desai
Published 2016-01-01

Crystal structures of influenza A virus matrix protein M1: variations on a theme.

by Martin K Safo, Faik N Musayev, Philip D Mosier, Qibing Zhou, Hang Xie, Umesh R Desai
Published 2014-01-01

Mucoadhesive role of tamarind xyloglucan on inflammation attenuates ulcerative colitis

by Srinivasan Periasamy, Chia-Hui Lin, Balaji Nagarajan, Nehru Viji Sankaranarayanan, Umesh R. Desai, Ming-Yie Liu
Published 2018-08-01

Tamarind xyloglucan attenuates dextran sodium sulfate induced ulcerative colitis: Role of antioxidation

by Srinivasan Periasamy, Chia-Hui Lin, Balaji Nagarajan, Nehru Viji Sankaranarayanan, Umesh R. Desai, Ming-Yie Liu
Published 2018-03-01

Sulfotransferase and Heparanase: Remodeling Engines in Promoting Virus Infection and Disease Development

by Dominik D. Kaltenbach, Dinesh Jaishankar, Meng Hao, Jacob C. Beer, Michael V. Volin, Umesh R. Desai, Vaibhav Tiwari
Published 2018-11-01

Solution structure of CXCL13 and heparan sulfate binding show that GAG binding site and cellular signalling rely on distinct domains

by Yoan R. Monneau, Lingjie Luo, Nehru Viji Sankaranarayanan, Balaji Nagarajan, Romain R. Vivès, Françoise Baleux, Umesh R. Desai, Fernando Arenzana-Seidedos, Hugues Lortat-Jacob
Published 2017-01-01

Inhibition of Human Cytomegalovirus Entry into Host Cells through A Pleiotropic Small Molecule

by James Elste, Dominik Kaltenbach, Vraj R. Patel, Max T. Nguyen, Harsh Sharthiya, Ritesh Tandon, Satish K. Mehta, Michael V. Volin, Michele Fornaro, Vaibhav Tiwari, Umesh R. Desai
Published 2020-02-01

A Synthetic, Small, Sulfated Agent Is a Promising Inhibitor of Chlamydia spp. Infection in vivo

by Karen M. Gallegos, Christopher R. Taylor, Christopher R. Taylor, Daniel J. Rabulinski, Rosalinda Del Toro, Danielle E. Girgis, Dapinder Jourha, Vaibhav Tiwari, Umesh R. Desai, Kyle H. Ramsey
Published 2019-01-01

High dose acetaminophen inhibits STAT3 and has free radical independent anti-cancer stem cell activity

by Pavani Pingali, Y. Jeffrey Wu, Rio Boothello, Chetna Sharon, Howard Li, Srinivas Sistla, Nehru Viji Sankaranarayanan, Umesh R. Desai, Anh T. Le, Robert C. Doebele, Leslie L. Muldoon, Bhaumik B. Patel, Alexander Neuwelt
Published 2021-03-01