Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity.

by Veronica R Placencio, Atsuhiko Ichimura, Toshio Miyata, Yves A DeClerck
Published 2015-01-01

Inhibition of Plasminogen Activator Inhibitor 1 Attenuates Hepatic Steatosis but Does Not Prevent Progressive Nonalcoholic Steatohepatitis in Mice

by Anne S. Henkel, Sadiya S. Khan, Shantel Olivares, Toshio Miyata, Douglas E. Vaughan
Published 2018-12-01

Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484

by Machteld Sillen, Toshio Miyata, Douglas E. Vaughan, Sergei V. Strelkov, Paul J. Declerck
Published 2021-02-01

A Case of Lipoprotein Glomerulopathy with apoE Chicago and apoE (Glu3Lys) Treated with Fenofibrate

by Hitoshi Kodera, Yasuhide Mizutani, Satoshi Sugiyama, Toshio Miyata, Takashi Ehara, Akira Matsunaga, Takao Saito
Published 2017-07-01

Body Weight Control by a High-Carbohydrate/Low-Fat Diet Slows the Progression of Diabetic Kidney Damage in an Obese, Hypertensive, Type 2 Diabetic Rat Model

by Shuichi Ohtomo, Yuko Izuhara, Masaomi Nangaku, Takashi Dan, Sadayoshi Ito, Charles van Ypersele de Strihou, Toshio Miyata
Published 2010-01-01

Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis.

by Nicolas Pelisch, Takashi Dan, Atsuhiko Ichimura, Hiroki Sekiguchi, Douglas E Vaughan, Charles van Ypersele de Strihou, Toshio Miyata
Published 2015-01-01

Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model.

by Bo Yeong Jeong, Md Jamal Uddin, Jong Hee Park, Jung Hwa Lee, Hi Bahl Lee, Toshio Miyata, Hunjoo Ha
Published 2016-01-01

Accumulation of Carbonyl Proteins in the Brain of Mouse Model for Methylglyoxal Detoxification Deficits

by Shin Koike, Kazuya Toriumi, Sakura Kasahara, Yosuke Kibune, Yo-ichi Ishida, Takashi Dan, Toshio Miyata, Makoto Arai, Yuki Ogasawara
Published 2021-04-01

Advanced Glycation Endproducts Are Increased in the Animal Model of Multiple Sclerosis but Cannot Be Reduced by Pyridoxamine Treatment or Glyoxalase 1 Overexpression

by Suzan Wetzels, Kristiaan Wouters, Toshio Miyata, Jean L. J. M. Scheijen, Jerome J. A. Hendriks, Casper G. Schalkwijk, Tim Vanmierlo
Published 2018-04-01

Nitric oxide prevents alveolar senescence and emphysema in a mouse model.

by Amanda E Boe, Mesut Eren, Luisa Morales-Nebreda, Sheila B Murphy, G R Scott Budinger, Gökhan M Mutlu, Toshio Miyata, Douglas E Vaughan
Published 2015-01-01

Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-1

by Shin-ichi Kawaguchi, Yuhei Gonda, Takuya Yamamoto, Yuki Sato, Hiroyuki Shinohara, Yohsuke Kobiki, Atsuhiko Ichimura, Takashi Dan, Motohiro Sonoda, Toshio Miyata, Akiya Ogawa, Tadayuki Tsujita
Published 2018-04-01

Skin autofluorescence is associated with the progression of chronic kidney disease: a prospective observational study.

by Kenichi Tanaka, Masaaki Nakayama, Makoto Kanno, Hiroshi Kimura, Kimio Watanabe, Yoshihiro Tani, Yuki Kusano, Hodaka Suzuki, Yoshimitsu Hayashi, Koichi Asahi, Keiji Sato, Toshio Miyata, Tsuyoshi Watanabe
Published 2013-01-01

Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice

by Jin Imai, Takashi Yahata, Hitoshi Ichikawa, Abd Aziz Ibrahim, Masaki Yazawa, Hideaki Sumiyoshi, Yutaka Inagaki, Masashi Matsushima, Takayoshi Suzuki, Tetsuya Mine, Kiyoshi Ando, Toshio Miyata, Katsuto Hozumi
Published 2020-04-01

Metabolic stress response implicated in diabetic retinopathy: The role of calpain, and the therapeutic impact of calpain inhibitor

by Ahmed Y. Shanab, Toru Nakazawa, Morin Ryu, Yuji Tanaka, Noriko Himori, Keiko Taguchi, Masayuki Yasuda, Ryo Watanabe, Jiro Takano, Takaomi Saido, Naoko Minegishi, Toshio Miyata, Toshiaki Abe, Masayuki Yamamoto
Published 2012-12-01

Mild Oxidative Damage in the Diabetic Rat Heart Is Attenuated by Glyoxalase-1 Overexpression

by Casper G. Schalkwijk, Coen D. A. Stehouwer, Geja Hageman, Ben J. A. Janssen, Frans van Nieuwenhoven, Toshio Miyata, Joyce M. J. de Vos-Houben, Petra M. G. Niessen, Olaf Brouwers
Published 2013-07-01

Inhibition of Plasminogen Activator Inhibitor-1 Activation Suppresses High Fat Diet-Induced Weight Gain via Alleviation of Hypothalamic Leptin Resistance

by Shinichiro Hosaka, Tetsuya Yamada, Kei Takahashi, Takashi Dan, Keizo Kaneko, Shinjiro Kodama, Yoichiro Asai, Yuichiro Munakata, Akira Endo, Hiroto Sugawara, Yohei Kawana, Junpei Yamamoto, Tomohito Izumi, Shojiro Sawada, Junta Imai, Toshio Miyata, Hideki Katagiri
Published 2020-06-01

Role of PAI-1 in hepatic steatosis and dyslipidemia

by Joshua A. Levine, Carlota Oleaga, Mesut Eren, Ansel P. Amaral, Meng Shang, Elizabeth Lux, Sadiya S. Khan, Sanjiv J. Shah, Yasuhiro Omura, Nathalie Pamir, Joshua Hay, Grant Barish, Toshio Miyata, Hagai Tavori, Sergio Fazio, Douglas E. Vaughan
Published 2021-01-01

Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex

by Kazuya Toriumi, Stefano Berto, Shin Koike, Noriyoshi Usui, Takashi Dan, Kazuhiro Suzuki, Mitsuhiro Miyashita, Yasue Horiuchi, Akane Yoshikawa, Mai Asakura, Kenichiro Nagahama, Hsiao-Chun Lin, Yuki Sugaya, Takaki Watanabe, Masanobu Kano, Yuki Ogasawara, Toshio Miyata, Masanari Itokawa, Genevieve Konopka, Makoto Arai
Published 2021-09-01