Metabolic and sympathovagal effects of bolus insulin glulisine versus basal insulin glargine therapy in people with type 2 diabetes: A randomized controlled study

by Yumie Takeshita, Takeo Tanaka, Hitomi Wakakuri, Yuki Kita, Takehiro Kanamori, Toshinari Takamura
Published 2021-07-01

p62‐mediated autophagy affects nutrition‐dependent insulin receptor substrate 1 dynamics in 3T3‐L1 preadipocytes

by Hirobumi Igawa, Akihiro Kikuchi, Hirofumi Misu, Kiyo‐aki Ishii, Shuichi Kaneko, Toshinari Takamura
Published 2019-01-01

Concentration-dependent dual effects of hydrogen peroxide on insulin signal transduction in H4IIEC hepatocytes.

by Satoshi Iwakami, Hirofumi Misu, Takashi Takeda, Makoto Sugimori, Seiichi Matsugo, Shuichi Kaneko, Toshinari Takamura
Published 2011-01-01

Effects of metformin and alogliptin on body composition in people with type 2 diabetes

by Yumie Takeshita, Yuki Kita, Ken‐ichiro Kato, Takehiro Kanamori, Hirofumi Misu, Shuichi Kaneko, Toshinari Takamura
Published 2019-05-01

Corrigendum to ‘Weight-adjusted lean body mass and calf circumference are protective against obesity-associated insulin resistance and metabolic abnormalities’

by Toshinari Takamura, Yuki Kita, Masatoshi Nakagen, Masaru Sakurai, Yuki Isobe, Yumie Takeshita, Kohzo Kawai, Takeshi Urabe, Shuichi Kaneko
Published 2017-07-01

Weight-adjusted lean body mass and calf circumference are protective against obesity-associated insulin resistance and metabolic abnormalities

by Toshinari Takamura, Yuki Kita, Masatoshi Nakagen, Masaru Sakurai, Yuki Isobe, Yumie Takeshita, Kohzo Kawai, Takeshi Urabe, Shuichi Kaneko
Published 2017-07-01

Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes.

by Hirofumi Misu, Kazuhide Ishikura, Seiichiro Kurita, Yumie Takeshita, Tsuguhito Ota, Yoshiro Saito, Kazuhiko Takahashi, Shuichi Kaneko, Toshinari Takamura
Published 2012-01-01

Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples.

by Masakazu Sugiyama, Akihiro Kikuchi, Hirofumi Misu, Hirobumi Igawa, Motooki Ashihara, Youichi Kushima, Kiyofumi Honda, Yoshiyuki Suzuki, Yoshiki Kawabe, Shuichi Kaneko, Toshinari Takamura
Published 2018-01-01

Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver disease.

by Ken-ichiro Kato, Toshinari Takamura, Yumie Takeshita, Yasuji Ryu, Hirofumi Misu, Tsuguhito Ota, Kumpei Tokuyama, Shoichiro Nagasaka, Munehide Matsuhisa, Osamu Matsui, Shuichi Kaneko
Published 2014-01-01

Effects of long-term androgen replacement therapy on the physical and mental statuses of aging males with late-onset hypogonadism: a multicenter randomized controlled trial in Japa...

by Hiroyuki Konaka, Kazuhiro Sugimoto, Hideki Orikasa, Teruaki Iwamoto, Toshinari Takamura, Yoshiyu Takeda, Kazuyoshi Shigehara, Masashi Iijima, Eitetsu Koh, Mikio Namiki, The EARTH study group
Published 2016-01-01

Eight-year longitudinal study of whole blood gene expression profiles in individuals undergoing long-term medical follow-up

by Yoshio Sakai, Alessandro Nasti, Yumie Takeshita, Miki Okumura, Shinji Kitajima, Masao Honda, Takashi Wada, Seiji Nakamura, Toshinari Takamura, Takuro Tamura, Kenichi Matsubara, Shuichi Kaneko
Published 2021-08-01

Reduction of estimated fluid volumes following initiation of empagliflozin in patients with type 2 diabetes and cardiovascular disease: a secondary analysis of the placebo-controll...

by Atsushi Tanaka, Michio Shimabukuro, Hiroki Teragawa, Yosuke Okada, Toshinari Takamura, Isao Taguchi, Shigeru Toyoda, Hirofumi Tomiyama, Shinichiro Ueda, Yukihito Higashi, Koichi Node, the EMBLEM Investigators
Published 2021-06-01

Comparison of the clinical effect of empagliflozin on glycemic and non-glycemic parameters in Japanese patients with type 2 diabetes and cardiovascular disease treated with or with...

by Atsushi Tanaka, Michio Shimabukuro, Hiroki Teragawa, Yosuke Okada, Toshinari Takamura, Isao Taguchi, Shigeru Toyoda, Hirofumi Tomiyama, Shinichiro Ueda, Yukihito Higashi, Koichi Node, the EMBLEM Investigators
Published 2021-07-01

Moderate alcohol consumption is associated with impaired insulin secretion and fasting glucose in non‐obese non‐diabetic men

by Sakae Miyagi, Toshinari Takamura, Thao Thi Thu Nguyen, Hiromasa Tsujiguchi, Akinori Hara, Haruki Nakamura, Keita Suzuki, Atsushi Tajima, Takayuki Kannon, Tadashi Toyama, Yasuhiro Kambayashi, Hiroyuki Nakamura
Published 2021-05-01

Endogenous Selenoprotein P, a Liver-Derived Secretory Protein, Mediates Myocardial Ischemia/Reperfusion Injury in Mice

by Hiroshi Chadani, Soichiro Usui, Oto Inoue, Takashi Kusayama, Shin-ichiro Takashima, Takeshi Kato, Hisayoshi Murai, Hiroshi Furusho, Ayano Nomura, Hirofumi Misu, Toshinari Takamura, Shuichi Kaneko, Masayuki Takamura
Published 2018-03-01

Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans

by Yuki Isobe, Hiroki Asakura, Hiromasa Tsujiguchi, Takayuki Kannon, Hiroaki Takayama, Yumie Takeshita, Kiyo-aki Ishii, Takehiro Kanamori, Akinori Hara, Tatsuya Yamashita, Atsushi Tajima, Shuichi Kaneko, Hiroyuki Nakamura, Toshinari Takamura
Published 2021-02-01

Corrigendum: Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans

by Yuki Isobe, Hiroki Asakura, Hiromasa Tsujiguchi, Takayuki Kannon, Hiroaki Takayama, Yumie Takeshita, Kiyo-aki Ishii, Takehiro Kanamori, Akinori Hara, Tatsuya Yamashita, Atsushi Tajima, Shuichi Kaneko, Hiroyuki Nakamura, Toshinari Takamura
Published 2021-08-01

Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models

by Yuichiro Mita, Kaho Nakayama, Shogo Inari, Yukina Nishito, Yuya Yoshioka, Naoko Sakai, Kanade Sotani, Takahiro Nagamura, Yuki Kuzuhara, Kumi Inagaki, Miki Iwasaki, Hirofumi Misu, Masaya Ikegawa, Toshinari Takamura, Noriko Noguchi, Yoshiro Saito
Published 2017-11-01

LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH

by Noboru Takata, Kiyo-aki Ishii, Hiroaki Takayama, Mayumi Nagashimada, Kyoko Kamoshita, Takeo Tanaka, Akihiro Kikuchi, Yumie Takeshita, Yukako Matsumoto, Tsuguhito Ota, Yasuhiko Yamamoto, Satoshi Yamagoe, Akihiro Seki, Yoshio Sakai, Shuichi Kaneko, Toshinari Takamura
Published 2021-01-01

Association of renal arteriosclerosis and hypertension with renal and cardiovascular outcomes in Japanese type 2 diabetes patients with diabetic nephropathy

by Miho Shimizu, Kengo Furuichi, Tadashi Toyama, Tomoaki Funamoto, Shinji Kitajima, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Toshinari Takamura, Kiyoki Kitagawa, Mitsuhiro Yoshimura, Shuichi Kaneko, Hitoshi Yokoyama, Takashi Wada, Kanazawa Study Group for Renal Diseases and Hypertension
Published 2019-07-01