Simple Genome Editing of Rodent Intact Embryos by Electroporation.

by Takehito Kaneko, Tomoji Mashimo
Published 2015-01-01

A missense mutation of the gene encoding synaptic vesicle glycoprotein 2A (SV2A) confers seizure susceptibility by disrupting amygdalar synaptic GABA release

by Kentaro Tokudome, Takahiro Okumura, Ryo Terada, Saki Shimizu, Naofumi Kunisawa, Tomoji Mashimo, Tomoji Mashimo, Tadao Serikawa, Tadao Serikawa, Masashi Sasa, Yukihiro Ohno
Published 2016-07-01

Genetic deletion of the 67‐kDa isoform of glutamate decarboxylase alters conditioned fear behavior in rats

by Kazuyuki Fujihara, Takumi Sato, Yoshiki Miyasaka, Tomoji Mashimo, Yuchio Yanagawa
Published 2021-02-01

ssODN-mediated knock-in with CRISPR-Cas for large genomic regions in zygotes

by Kazuto Yoshimi, Yayoi Kunihiro, Takehito Kaneko, Hitoshi Nagahora, Birger Voigt, Tomoji Mashimo
Published 2016-01-01

Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases.

by Tomoji Mashimo, Akiko Takizawa, Birger Voigt, Kazuto Yoshimi, Hiroshi Hiai, Takashi Kuramoto, Tadao Serikawa
Published 2010-01-01

Behavioral Consequences of a Combination of Gad1 Haplodeficiency and Adolescent Exposure to an NMDA Receptor Antagonist in Long-Evans Rats

by Kazuyuki Fujihara, Kazuyuki Fujihara, Takumi Sato, Kazuya Higeta, Yoshiki Miyasaka, Tomoji Mashimo, Yuchio Yanagawa
Published 2021-03-01

Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in <i>Leucine-Rich Glioma-Inactivated 1</i> (<i>Lgi1</i>) Mutant Rats

by Masato Kinboshi, Saki Shimizu, Tomoji Mashimo, Tadao Serikawa, Hidefumi Ito, Akio Ikeda, Ryosuke Takahashi, Yukihiro Ohno
Published 2019-02-01

Scn1a missense mutation causes limbic hyperexcitability and vulnerability to experimental febrile seizures

by Yukihiro Ohno, Shizuka Ishihara, Tomoji Mashimo, Nobumasa Sofue, Saki Shimizu, Takuji Imaoku, Toshiko Tsurumi, Masashi Sasa, Tadao Serikawa
Published 2011-02-01

Correction: Novel ENU-Induced Mutation in Tbx6 Causes Dominant Spondylocostal Dysostosis-Like Vertebral Malformations in the Rat.

by Koichiro Abe, Nobuhiko Takamatsu, Kumiko Ishikawa, Toshiko Tsurumi, Sho Tanimoto, Yukina Sakurai, Thomas S Lisse, Kenji Imai, Tadao Serikawa, Tomoji Mashimo
Published 2015-01-01

Novel ENU-Induced Mutation in Tbx6 Causes Dominant Spondylocostal Dysostosis-Like Vertebral Malformations in the Rat.

by Koichiro Abe, Nobuhiko Takamatsu, Kumiko Ishikawa, Toshiko Tsurumi, Sho Tanimoto, Yukina Sakurai, Thomas S Lisse, Kenji Imai, Tadao Serikawa, Tomoji Mashimo
Published 2015-01-01

Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase.

by Tomoji Mashimo, Ouadah Hadjebi, Fabiola Amair-Pinedo, Toshiko Tsurumi, Francina Langa, Tadao Serikawa, Constantino Sotelo, Jean-Louis Guénet, Jose Luis Rosa
Published 2009-12-01

Deletion of B-cell translocation gene 2 (BTG2) alters the responses of glial cells in white matter to chronic cerebral hypoperfusion

by Kaoru Suzuki, Mitsuru Shinohara, Yoshihiro Uno, Yoshitaka Tashiro, Ghupurjan Gheni, Miho Yamamoto, Akio Fukumori, Akihiko Shindo, Tomoji Mashimo, Hidekazu Tomimoto, Naoyuki Sato
Published 2021-04-01

Null mutation of the endothelin receptor type B gene causes embryonic death in the GK rat.

by Jinxi Wang, Ruihua Dang, Yoshiki Miyasaka, Kousuke Hattori, Daisuke Torigoe, Tadashi Okamura, Hassan T Tag-Ei-Din-Hassan, Masami Morimatsu, Tomoji Mashimo, Takashi Agui
Published 2019-01-01

CRISPR-Cas3 induces broad and unidirectional genome editing in human cells

by Hiroyuki Morisaka, Kazuto Yoshimi, Yuya Okuzaki, Peter Gee, Yayoi Kunihiro, Ekasit Sonpho, Huaigeng Xu, Noriko Sasakawa, Yuki Naito, Shinichiro Nakada, Takashi Yamamoto, Shigetoshi Sano, Akitsu Hotta, Junji Takeda, Tomoji Mashimo
Published 2019-12-01

CLICK: one-step generation of conditional knockout mice

by Yoshiki Miyasaka, Yoshihiro Uno, Kazuto Yoshimi, Yayoi Kunihiro, Takuji Yoshimura, Tomohiro Tanaka, Harumi Ishikubo, Yuichi Hiraoka, Norihiko Takemoto, Takao Tanaka, Yoshihiro Ooguchi, Paul Skehel, Tomomi Aida, Junji Takeda, Tomoji Mashimo
Published 2018-05-01

CRISPR/Cas9-engineered Gad1 elimination in rats leads to complex behavioral changes: implications for schizophrenia

by Kazuyuki Fujihara, Kazuo Yamada, Yukio Ichitani, Toshikazu Kakizaki, Weiru Jiang, Shigeo Miyata, Takashi Suto, Daiki Kato, Shigeru Saito, Masahiko Watanabe, Yuki Kajita, Tomokazu Ohshiro, Hajime Mushiake, Yoshiki Miyasaka, Tomoji Mashimo, Hiroki Yasuda, Yuchio Yanagawa
Published 2020-12-01

Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver

by Tomoaki Ueda, Takafumi Yokota, Daisuke Okuzaki, Yoshihiro Uno, Tomoji Mashimo, Yoshiaki Kubota, Takao Sudo, Tomohiko Ishibashi, Yasuhiro Shingai, Yukiko Doi, Takayuki Ozawa, Ritsuko Nakai, Akira Tanimura, Michiko Ichii, Sachiko Ezoe, Hirohiko Shibayama, Kenji Oritani, Yuzuru Kanakura
Published 2019-12-01

Generation and Characterization of Severe Combined Immunodeficiency Rats

by Tomoji Mashimo, Akiko Takizawa, Junya Kobayashi, Yayoi Kunihiro, Kazuto Yoshimi, Saeko Ishida, Koji Tanabe, Ami Yanagi, Asato Tachibana, Jun Hirose, Jun-ichiro Yomoda, Shiho Morimoto, Takashi Kuramoto, Birger Voigt, Takeshi Watanabe, Hiroshi Hiai, Chise Tateno, Kenshi Komatsu, Tadao Serikawa
Published 2012-09-01

Creating a stem cell niche in the inner ear using self-assembling peptide amphiphiles.

by Akihiro J Matsuoka, Zafar A Sayed, Nicholas Stephanopoulos, Eric J Berns, Anil R Wadhwani, Zachery D Morrissey, Duncan M Chadly, Shun Kobayashi, Alexandra N Edelbrock, Tomoji Mashimo, Charles A Miller, Tammy L McGuire, Samuel I Stupp, John A Kessler
Published 2017-01-01

Depdc5 knockout rat: A novel model of mTORopathy

by Elise Marsan, Saeko Ishida, Adrien Schramm, Sarah Weckhuysen, Giuseppe Muraca, Sarah Lecas, Ning Liang, Caroline Treins, Mario Pende, Delphine Roussel, Michel Le Van Quyen, Tomoji Mashimo, Takehito Kaneko, Takashi Yamamoto, Tetsushi Sakuma, Séverine Mahon, Richard Miles, Eric Leguern, Stéphane Charpier, Stéphanie Baulac
Published 2016-05-01