Multinomial modelling of TB/HIV co-infection yields a robust predictive signature and generates hypotheses about the HIV+TB+ disease state.

by Fergal J Duffy, Ethan G Thompson, Thomas J Scriba, Daniel E Zak
Published 2019-01-01

St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death.

by Britta Kleemann, Benjamin Loos, Thomas J Scriba, Dirk Lang, Lester M Davids
Published 2014-01-01

Polyfunctional CD4+ T Cells As Targets for Tuberculosis Vaccination

by Deborah A. Lewinsohn, David M. Lewinsohn, David M. Lewinsohn, Thomas J. Scriba
Published 2017-10-01

A comparison of antigen-specific T cell responses induced by six novel tuberculosis vaccine candidates.

by Miguel J Rodo, Virginie Rozot, Elisa Nemes, One Dintwe, Mark Hatherill, Francesca Little, Thomas J Scriba
Published 2019-03-01

Host blood transcriptomic biomarkers of tuberculosis disease in people living with HIV: a systematic review protocol

by Mary Shelton, Humphrey Mulenga, Stanley Kimbung Mbandi, Simon C Mendelsohn, Mark Hatherill, Fatoumatta Darboe, Thomas J Scriba
Published 2021-08-01

The effect of antiretroviral treatment on selected genes in whole blood from HIV-infected adults sensitised by Mycobacterium tuberculosis.

by Nishtha Jhilmeet, David M Lowe, Catherine Riou, Thomas J Scriba, Anna Coussens, Rene Goliath, Robert J Wilkinson, Katalin Andrea Wilkinson
Published 2018-01-01

Identification of antigens specific to non-tuberculous mycobacteria: the Mce family of proteins as a target of T cell immune responses.

by Anna M Checkley, David H Wyllie, Thomas J Scriba, Tanya Golubchik, Adrian V S Hill, Willem A Hanekom, Helen McShane
Published 2011-01-01

Immune profiling of Mycobacterium tuberculosis-specific T cells in recent and remote infection

by Cheleka A.M. Mpande, Virginie Rozot, Boitumelo Mosito, Munyaradzi Musvosvi, One B. Dintwe, Nicole Bilek, Mark Hatherill, Thomas J. Scriba, Elisa Nemes
Published 2021-02-01

Performance of diagnostic and predictive host blood transcriptomic signatures for Tuberculosis disease: A systematic review and meta-analysis.

by Humphrey Mulenga, Chambrez-Zita Zauchenberger, Erick W Bunyasi, Stanley Kimbung Mbandi, Simon C Mendelsohn, Benjamin Kagina, Adam Penn-Nicholson, Thomas J Scriba, Mark Hatherill
Published 2020-01-01

Elevated IgG Responses in Infants Are Associated With Reduced Prevalence of Mycobacterium tuberculosis Infection

by Erin Logan, Angelique Kany Kany Luabeya, Angelique Kany Kany Luabeya, Humphrey Mulenga, Humphrey Mulenga, Dunja Mrdjen, Cynthia Ontong, Cynthia Ontong, Adam F. Cunningham, Michele Tameris, Michele Tameris, Helen McShane, Thomas J. Scriba, Thomas J. Scriba, William G. C. Horsnell, William G. C. Horsnell, William G. C. Horsnell, Mark Hatherill, Mark Hatherill
Published 2018-07-01

Regional changes in tuberculosis disease burden among adolescents in South Africa (2005-2015).

by Erick Wekesa Bunyasi, Humphrey Mulenga, Angelique K K Luabeya, Justin Shenje, Simon C Mendelsohn, Elisa Nemes, Michele Tameris, Robin Wood, Thomas J Scriba, Mark Hatherill
Published 2020-01-01

Immune Phenotype and Functionality of <i>Mtb-</i>Specific<i> </i>T-Cells in HIV/TB Co-Infected Patients on Antiretroviral Treatment

by Lucy Mupfumi, Cheleka A.M. Mpande, Tim Reid, Sikhulile Moyo, Sanghyuk S. Shin, Nicola Zetola, Tuelo Mogashoa, Rosemary M. Musonda, Ishmael Kasvosve, Thomas J. Scriba, Elisa Nemes, Simani Gaseitsiwe
Published 2020-03-01

The candidate TB vaccine, MVA85A, induces highly durable Th1 responses.

by Michele Tameris, Hennie Geldenhuys, Angelique KanyKany Luabeya, Erica Smit, Jane E Hughes, Samantha Vermaak, Willem A Hanekom, Mark Hatherill, Hassan Mahomed, Helen McShane, Thomas J Scriba
Published 2014-01-01

Multidimensional analysis of immune responses identified biomarkers of recent Mycobacterium tuberculosis infection.

by Tessa Lloyd, Pia Steigler, Cheleka A M Mpande, Virginie Rozot, Boitumelo Mosito, Constance Schreuder, Timothy D Reid, Mark Hatherill, Thomas J Scriba, Francesca Little, Elisa Nemes, ACS Study Team
Published 2021-07-01

Evaluation of Xpert® MTB/RIF Assay in Induced Sputum and Gastric Lavage Samples from Young Children with Suspected Tuberculosis from the MVA85A TB Vaccine Trial.

by Erick Wekesa Bunyasi, Michele Tameris, Hennie Geldenhuys, Bey-Marrie Schmidt, Angelique Kany Kany Luabeya, Humphrey Mulenga, Thomas J Scriba, Willem A Hanekom, Hassan Mahomed, Helen McShane, Mark Hatherill
Published 2015-01-01

Plasma Type I IFN Protein Concentrations in Human Tuberculosis

by Alba Llibre, Alba Llibre, Nicole Bilek, Vincent Bondet, Vincent Bondet, Fatoumatta Darboe, Stanley Kimbung Mbandi, Adam Penn-Nicholson, Mark Hatherill, Flore Rozenberg, Thomas J. Scriba, Darragh Duffy, Darragh Duffy
Published 2019-08-01

Effect of Inflammatory Cytokines/Chemokines on Pulmonary Tuberculosis Culture Conversion and Disease Severity in HIV-Infected and -Uninfected Individuals From South Africa

by Santhuri Rambaran, Kogieleum Naidoo, Kogieleum Naidoo, Lara Lewis, Razia Hassan-Moosa, Razia Hassan-Moosa, Dhineshree Govender, Natasha Samsunder, Thomas J. Scriba, Nesri Padayatchi, Nesri Padayatchi, Aida Sivro, Aida Sivro
Published 2021-04-01

Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes

by Louis R. Joslyn, Louis R. Joslyn, Elsje Pienaar, Elsje Pienaar, Robert M. DiFazio, Sara Suliman, Benjamin M. Kagina, JoAnne L. Flynn, Thomas J. Scriba, Jennifer J. Linderman, Denise E. Kirschner
Published 2018-08-01

Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria.

by Andrew D Graustein, Elizabeth A Misch, Munyaradzi Musvosvi, Muki Shey, Javeed A Shah, Chetan Seshadri, Augustine Ajuogu, Kathryn Bowman, Humphrey Mulenga, Ashley Veldsman, Willem A Hanekom, Mark Hatherill, Thomas J Scriba, Thomas R Hawn
Published 2018-01-01

A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans.

by Cecilia S Lindestam Arlehamn, Denise M McKinney, Chelsea Carpenter, Sinu Paul, Virginie Rozot, Edward Makgotlho, Yolande Gregg, Michele van Rooyen, Joel D Ernst, Mark Hatherill, Willem A Hanekom, Bjoern Peters, Thomas J Scriba, Alessandro Sette
Published 2016-07-01