Targeting Unconventional Host Components for Vaccination-Induced Protection Against TB

by Elisa Nemes, Shabaana A. Khader, Rosemary V. Swanson, Willem A. Hanekom
Published 2020-07-01

Induction of Granulysin and Perforin Cytolytic Mediator Expression in 10-Week-Old Infants Vaccinated with BCG at Birth

by Patricia L. Semple, Marcia Watkins, Virginia Davids, Alan M. Krensky, Willem A. Hanekom, Gilla Kaplan, Stanley Ress
Published 2011-01-01

CD8+ T-cell interleukin-7 receptor alpha expression as a potential indicator of disease status in HIV-infected children.

by Tanvi S Sharma, Jane Hughes, Amarylis Murillo, Joanne Riley, Andreia Soares, Francesca Little, Charles D Mitchell, Willem A Hanekom
Published 2008-01-01

Correction: The Tuberculin Skin Test versus QuantiFERON TB Gold® in Predicting Tuberculosis Disease in an Adolescent Cohort Study in South Africa

by Hassan Mahomed, Tony Hawkridge, Suzanne Verver, Deborah Abrahams, Lawrence Geiter, Mark Hatherill, Rodney Ehrlich, Willem A. Hanekom, Gregory D. Hussey
Published 2011-01-01

The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa.

by Hassan Mahomed, Tony Hawkridge, Suzanne Verver, Deborah Abrahams, Lawrence Geiter, Mark Hatherill, Rodney Ehrlich, Willem A Hanekom, Gregory D Hussey
Published 2011-03-01

Identification of antigens specific to non-tuberculous mycobacteria: the Mce family of proteins as a target of T cell immune responses.

by Anna M Checkley, David H Wyllie, Thomas J Scriba, Tanya Golubchik, Adrian V S Hill, Willem A Hanekom, Helen McShane
Published 2011-01-01

Correction: The Tuberculin Skin Test versus QuantiFERON TB Gold® in Predicting Tuberculosis Disease in an Adolescent Cohort Study in South Africa.

by Hassan Mahomed, Tony Hawkridge, Suzanne Verver, Deborah Abrahams, Lawrence Geiter, Mark Hatherill, Rodney Ehrlich, Willem A. Hanekom, Gregory D. Hussey
Published 2011-01-01

HIV Is Associated with Modified Humoral Immune Responses in the Setting of HIV/TB Coinfection

by Esther van Woudenbergh, Edward B. Irvine, Leela Davies, Marwou de Kock, Willem A. Hanekom, Cheryl L. Day, Sarah Fortune, Galit Alter
Published 2020-05-01

Patients with tuberculosis disease have Mycobacterium tuberculosis-specific CD8 T cells with a pro-apoptotic phenotype and impaired proliferative capacity, which is not restored fo...

by Cheryl L Day, Noella D Moshi, Deborah A Abrahams, Michele van Rooyen, Terrence O'rie, Marwou de Kock, Willem A Hanekom
Published 2014-01-01

A comparative analysis of polyfunctional T cells and secreted cytokines induced by Bacille Calmette-Guérin immunisation in children and adults.

by Nicole Ritz, Madeleine Strach, Carmen Yau, Binita Dutta, Marc Tebruegge, Tom G Connell, Willem A Hanekom, Warwick J Britton, Roy Robins-Browne, Nigel Curtis
Published 2012-01-01

The candidate TB vaccine, MVA85A, induces highly durable Th1 responses.

by Michele Tameris, Hennie Geldenhuys, Angelique KanyKany Luabeya, Erica Smit, Jane E Hughes, Samantha Vermaak, Willem A Hanekom, Mark Hatherill, Hassan Mahomed, Helen McShane, Thomas J Scriba
Published 2014-01-01

Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations.

by Willem A Hanekom, Hazel M Dockrell, Tom H M Ottenhoff, T Mark Doherty, Helen Fletcher, Helen McShane, Frank F Weichold, Dan F Hoft, Shreemanta K Parida, Uli J Fruth
Published 2008-07-01

Evaluation of Xpert® MTB/RIF Assay in Induced Sputum and Gastric Lavage Samples from Young Children with Suspected Tuberculosis from the MVA85A TB Vaccine Trial.

by Erick Wekesa Bunyasi, Michele Tameris, Hennie Geldenhuys, Bey-Marrie Schmidt, Angelique Kany Kany Luabeya, Humphrey Mulenga, Thomas J Scriba, Willem A Hanekom, Hassan Mahomed, Helen McShane, Mark Hatherill
Published 2015-01-01

PD-1 Expression on Mycobacterium tuberculosis-Specific CD4 T Cells Is Associated With Bacterial Load in Human Tuberculosis

by Cheryl L. Day, Cheryl L. Day, Deborah A. Abrahams, Rubina Bunjun, Lynnett Stone, Marwou de Kock, Gerhard Walzl, Robert J. Wilkinson, Robert J. Wilkinson, Robert J. Wilkinson, Wendy A. Burgers, Willem A. Hanekom
Published 2018-08-01

Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria.

by Andrew D Graustein, Elizabeth A Misch, Munyaradzi Musvosvi, Muki Shey, Javeed A Shah, Chetan Seshadri, Augustine Ajuogu, Kathryn Bowman, Humphrey Mulenga, Ashley Veldsman, Willem A Hanekom, Mark Hatherill, Thomas J Scriba, Thomas R Hawn
Published 2018-01-01

A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans.

by Cecilia S Lindestam Arlehamn, Denise M McKinney, Chelsea Carpenter, Sinu Paul, Virginie Rozot, Edward Makgotlho, Yolande Gregg, Michele van Rooyen, Joel D Ernst, Mark Hatherill, Willem A Hanekom, Bjoern Peters, Thomas J Scriba, Alessandro Sette
Published 2016-07-01

Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.

by Simone A Joosten, Krista E van Meijgaarden, Pascale C van Weeren, Fatima Kazi, Annemieke Geluk, Nigel D L Savage, Jan W Drijfhout, Darren R Flower, Willem A Hanekom, Michèl R Klein, Tom H M Ottenhoff
Published 2010-02-01

HIV Infection Is Associated With Downregulation of BTLA Expression on Mycobacterium tuberculosis-Specific CD4 T Cells in Active Tuberculosis Disease

by Morgan S. Barham, Deborah A. Abrahams, Jeremiah Khayumbi, Joshua Ongalo, Joan Tonui, Angela Campbell, Marwou de Kock, Samuel Gurrion Ouma, Felix Hayara Odhiambo, Willem A. Hanekom, Neel R. Gandhi, Neel R. Gandhi, Cheryl L. Day, Cheryl L. Day
Published 2019-08-01

Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants.

by April Kaur Randhawa, Muki S Shey, Alana Keyser, Blas Peixoto, Richard D Wells, Marwou de Kock, Lesedi Lerumo, Jane Hughes, Gregory Hussey, Anthony Hawkridge, Gilla Kaplan, Willem A Hanekom, Thomas R Hawn, South African Tuberculosis Vaccine Initiative Team
Published 2011-08-01

Genetic variation in TLR genes in Ugandan and South African populations and comparison with HapMap data.

by Allison R Baker, Feiyou Qiu, April Kaur Randhawa, David J Horne, Mark D Adams, Muki Shey, Jill Barnholtz-Sloan, Harriet Mayanja-Kizza, Gilla Kaplan, Willem A Hanekom, W Henry Boom, Thomas R Hawn, Catherine M Stein, Tuberculosis Research Unit and South African Tuberculosis Vaccine Initiative Team
Published 2012-01-01