Unexpected binding behaviors of bacterial Argonautes in human cells cast doubts on their use as targetable gene regulators.

by Henriette O'Geen, Chonghua Ren, Nicole B Coggins, Sofie L Bates, David J Segal
Published 2018-01-01

Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner

by Henriette O’Geen, Sofie L. Bates, Sakereh S. Carter, Karly A. Nisson, Julian Halmai, Kyle D. Fink, Suhn K. Rhie, Peggy J. Farnham, David J. Segal
Published 2019-05-01