Bacteria herald a new era of gene editing

by David J Segal
Published 2013-01-01

UBE3A: An E3 Ubiquitin Ligase With Genome-Wide Impact in Neurodevelopmental Disease

by Simon Jesse Lopez, Simon Jesse Lopez, Simon Jesse Lopez, Simon Jesse Lopez, David J. Segal, David J. Segal, David J. Segal, David J. Segal, Janine M. LaSalle, Janine M. LaSalle, Janine M. LaSalle, Janine M. LaSalle
Published 2019-01-01

Unexpected binding behaviors of bacterial Argonautes in human cells cast doubts on their use as targetable gene regulators.

by Henriette O'Geen, Chonghua Ren, Nicole B Coggins, Sofie L Bates, David J Segal
Published 2018-01-01

Miz-1 activates gene expression via a novel consensus DNA binding motif.

by Bonnie L Barrilleaux, Dana Burow, Sarah H Lockwood, Abigail Yu, David J Segal, Paul S Knoepfler
Published 2014-01-01

The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres.

by Amanda K Frank, Duy C Tran, Roy W Qu, Bradley A Stohr, David J Segal, Lifeng Xu
Published 2015-07-01

Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner

by Henriette O’Geen, Sofie L. Bates, Sakereh S. Carter, Karly A. Nisson, Julian Halmai, Kyle D. Fink, Suhn K. Rhie, Peggy J. Farnham, David J. Segal
Published 2019-05-01

Allele-Specific Reduction of the Mutant Huntingtin Allele Using Transcription Activator-Like Effectors in Human Huntington's Disease Fibroblasts

by Kyle D. Fink Ph.D, Peter Deng, Josh Gutierrez, Joseph S. Anderson, Audrey Torrest, Anvita Komarla, Stefanos Kalomoiris, Whitney Cary, Johnathon D. Anderson, William Gruenloh, Alexandra Duffy, Teresa Tempkin, Geralyn Annett, Vicki Wheelock, David J. Segal, Jan A. Nolta
Published 2016-04-01

Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation

by Jai Woong Seo, Elizabeth S. Ingham, Lisa Mahakian, Spencer Tumbale, Bo Wu, Sadaf Aghevlian, Shahin Shams, Mo Baikoghli, Poorva Jain, Xiaozhe Ding, Nick Goeden, Tatyana Dobreva, Nicholas C. Flytzanis, Michael Chavez, Kratika Singhal, Ryan Leib, Michelle L. James, David J. Segal, R. Holland Cheng, Eduardo A. Silva, Viviana Gradinaru, Katherine W. Ferrara
Published 2020-04-01