Topoisomerases and cancer chemotherapy: recent advances and unanswered questions [version 1; peer review: 3 approved]

by Mary-Ann Bjornsti, Scott H. Kaufmann
Published 2019-09-01

Prospects for the Use of ATR Inhibitors to Treat Cancer

by Scott H. Kaufmann, Jill M. Wagner
Published 2010-04-01

How does doxorubicin work?

by Anand G Patel, Scott H Kaufmann
Published 2012-12-01

Mitochondrial apoptosis and BH3 mimetics [version 1; referees: 3 approved]

by Haiming Dai, X. Wei Meng, Scott H. Kaufmann
Published 2016-12-01

BCL2 Family, Mitochondrial Apoptosis, and Beyond

by Haiming Dai, X Wei Meng, Scott H Kaufmann
Published 2016-01-01

The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells

by Silvana eDe Lorenzo, Anand ePatel, Rachel eHurley, Scott H. Kaufmann
Published 2013-09-01

FAM111A protects replication forks from protein obstacles via its trypsin-like domain

by Yusuke Kojima, Yuka Machida, Sowmiya Palani, Thomas R. Caulfield, Evette S. Radisky, Scott H. Kaufmann, Yuichi J. Machida
Published 2020-03-01

The Trifecta of Single-Cell, Systems-Biology, and Machine-Learning Approaches

by Taylor M. Weiskittel, Cristina Correia, Grace T. Yu, Choong Yong Ung, Scott H. Kaufmann, Daniel D. Billadeau, Hu Li
Published 2021-07-01

Characterization of an alternative BAK-binding site for BH3 peptides

by Kaiqin Ye, Wei X. Meng, Hongbin Sun, Bo Wu, Meng Chen, Yuan-Ping Pang, Jia Gao, Hongzhi Wang, Junfeng Wang, Scott H. Kaufmann, Haiming Dai
Published 2020-07-01

ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer

by Arun Kanakkanthara, Catherine J. Huntoon, Xiaonan Hou, Minzhi Zhang, Ethan P. Heinzen, Daniel R. O’Brien, Ann L. Oberg, S. John Weroha, Scott H. Kaufmann, Larry M. Karnitz
Published 2019-10-01

Reactivating latent HIV with PKC agonists induces resistance to apoptosis and is associated with phosphorylation and activation of BCL2.

by Andrea J French, Sekar Natesampillai, Ashton Krogman, Cristina Correia, Kevin L Peterson, Alecia Alto, Aswath P Chandrasekar, Anisha Misra, Ying Li, Scott H Kaufmann, Andrew D Badley, Nathan W Cummins
Published 2020-10-01

Constitutive BAK/MCL1 complexes predict paclitaxel and S63845 sensitivity of ovarian cancer

by Dongyan Liu, Xiaonan Hou, Wangyu Wu, Valentina Zafagnin, Yunjian Li, Cristina Correia, Zhiyang Zhao, Chenggang Zhao, Zhirong Liu, Tao Zhang, Zhiyou Fang, Hongzhi Wang, Chao Xu, Saravut J. Weroha, Scott H. Kaufmann, Haiming Dai
Published 2021-08-01

Gadolinium-enhanced cardiac MR exams of human subjects are associated with significant increases in the DNA repair marker 53BP1, but not the damage marker γH2AX.

by Jennifer S McDonald, Robert J McDonald, Jacob B Ekins, Anthony S Tin, Sylvain Costes, Tamara M Hudson, Dana J Schroeder, Kevin Kallmes, Scott H Kaufmann, Philip M Young, Aiming Lu, Ramanathan Kadirvel, David F Kallmes
Published 2018-01-01

Correction: Gadolinium-enhanced cardiac MR exams of human subjects are associated with significant increases in the DNA repair marker 53BP1, but not the damage marker γH2AX.

by Jennifer S McDonald, Robert J McDonald, Jacob B Ekins, Antony S Tin, Sylvain Costes, Tamara M Hudson, Dana J Schroeder, Kevin Kallmes, Scott H Kaufmann, Philip M Young, Aiming Lu, Ramanathan Kadirvel, David F Kallmes
Published 2018-01-01

Statistical analysis of comparative tumor growth repeated measures experiments in the ovarian cancer patient derived xenograft (PDX) setting

by Ann L. Oberg, Ethan P. Heinzen, Xiaonan Hou, Mariam M. Al Hilli, Rachel M. Hurley, Andrea E. Wahner Hendrickson, Krista M. Goergen, Melissa C. Larson, Marc A. Becker, Jeanette E. Eckel-Passow, Matthew J. Maurer, Scott H. Kaufmann, Paul Haluska, S. John Weroha
Published 2021-04-01

A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice

by Haoxing Zhang, Hailong Liu, Yali Chen, Xu Yang, Panfei Wang, Tongzheng Liu, Min Deng, Bo Qin, Cristina Correia, Seungbaek Lee, Jungjin Kim, Melanie Sparks, Asha A. Nair, Debra L. Evans, Krishna R. Kalari, Pumin Zhang, Liewei Wang, Zhongsheng You, Scott H. Kaufmann, Zhenkun Lou, Huadong Pei
Published 2016-01-01

Porphyromonas somerae Invasion of Endometrial Cancer Cells

by Taylor A. Crooks, Taylor A. Crooks, Joseph D. Madison, Joseph D. Madison, Joseph D. Madison, Dana M. Walsh, William G. Herbert, William G. Herbert, Patricio R. Jeraldo, Patricio R. Jeraldo, Nicholas Chia, Nicholas Chia, William A. Cliby, Scott H. Kaufmann, Marina R. S. Walther-Antonio, Marina R. S. Walther-Antonio, Marina R. S. Walther-Antonio
Published 2021-07-01

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

by Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria I. Harrell, Giada V. Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B. Pearson, John J. Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J. Hutt, Scott H. Kaufmann, Kevin K. Lin, Thomas C. Harding, Nadia Traficante, Australian Ovarian Cancer Study (AOCS), Anna deFazio, Iain A. McNeish, David D. Bowtell, Elizabeth M. Swisher, Alexander Dobrovic, Matthew J. Wakefield, Clare L. Scott
Published 2018-09-01

RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis

by Ryan M. Carr, Denis Vorobyev, Terra Lasho, David L. Marks, Ezequiel J. Tolosa, Alexis Vedder, Luciana L. Almada, Andrey Yurcheko, Ismael Padioleau, Bonnie Alver, Giacomo Coltro, Moritz Binder, Stephanie L. Safgren, Isaac Horn, Xiaona You, Eric Solary, Maria E. Balasis, Kurt Berger, James Hiebert, Thomas Witzig, Ajinkya Buradkar, Temeida Graf, Peter Valent, Abhishek A. Mangaonkar, Keith D. Robertson, Matthew T. Howard, Scott H. Kaufmann, Christopher Pin, Martin E. Fernandez-Zapico, Klaus Geissler, Nathalie Droin, Eric Padron, Jing Zhang, Sergey Nikolaev, Mrinal M. Patnaik
Published 2021-05-01

Molecular and clinical determinants of response and resistance to rucaparib for recurrent ovarian cancer treatment in ARIEL2 (Parts 1 and 2)

by Elizabeth M. Swisher, Tanya T. Kwan, Amit M. Oza, Anna V. Tinker, Isabelle Ray-Coquard, Ana Oaknin, Robert L. Coleman, Carol Aghajanian, Gottfried E. Konecny, David M. O’Malley, Alexandra Leary, Diane Provencher, Stephen Welch, Lee-may Chen, Andrea E. Wahner Hendrickson, Ling Ma, Prafull Ghatage, Rebecca S. Kristeleit, Oliver Dorigo, Ashan Musafer, Scott H. Kaufmann, Julia A. Elvin, Douglas I. Lin, Setsuko K. Chambers, Erin Dominy, Lan-Thanh Vo, Sandra Goble, Lara Maloney, Heidi Giordano, Thomas Harding, Alexander Dobrovic, Clare L. Scott, Kevin K. Lin, Iain A. McNeish
Published 2021-05-01