Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer

by Iva Marković, Iva Marković, Savvas N. Savvides, Savvas N. Savvides
Published 2020-07-01

Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors

by Aurora Holgado, Aurora Holgado, Harald Braun, Harald Braun, Kenneth Verstraete, Kenneth Verstraete, Domien Vanneste, Domien Vanneste, Nico Callewaert, Nico Callewaert, Savvas N. Savvides, Savvas N. Savvides, Inna S. Afonina, Inna S. Afonina, Rudi Beyaert, Rudi Beyaert
Published 2020-07-01

Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33

by Andrea R. Teufelberger, Sharon Van Nevel, Paco Hulpiau, Paco Hulpiau, Maria Nordengrün, Savvas N. Savvides, Savvas N. Savvides, Sarah De Graeve, Srinivas Akula, Gabriele Holtappels, Natalie De Ruyck, Wim Declercq, Wim Declercq, Peter Vandenabeele, Peter Vandenabeele, Lars Hellman, Barbara M. Bröker, Dmitri V. Krysko, Dmitri V. Krysko, Dmitri V. Krysko, Claus Bachert, Claus Bachert, Claus Bachert, Olga Krysko, Olga Krysko
Published 2020-09-01

Attenuated CSF‐1R signalling drives cerebrovascular pathology

by Conor Delaney, Michael Farrell, Colin P Doherty, Kiva Brennan, Eoin O’Keeffe, Chris Greene, Kieva Byrne, Eoin Kelly, Niamh Birmingham, Paula Hickey, Simon Cronin, Savvas N Savvides, Sarah L Doyle, Matthew Campbell
Published 2021-02-01

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

by Kenneth Verstraete, Frank Peelman, Harald Braun, Juan Lopez, Dries Van Rompaey, Ann Dansercoer, Isabel Vandenberghe, Kris Pauwels, Jan Tavernier, Bart N. Lambrecht, Hamida Hammad, Hans De Winter, Rudi Beyaert, Guy Lippens, Savvas N. Savvides
Published 2017-04-01

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

by Srinath Govindarajan, Djoere Gaublomme, Renée Van der Cruyssen, Eveline Verheugen, Sofie Van Gassen, Yvan Saeys, Simon Tavernier, Takao Iwawaki, Yehudi Bloch, Savvas. N. Savvides, Bart N. Lambrecht, Sophie Janssens, Dirk Elewaut, Michael B. Drennan
Published 2018-12-01

Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF

by Jan Felix, Eaazhisai Kandiah, Steven De Munck, Yehudi Bloch, Gydo C.P. van Zundert, Kris Pauwels, Ann Dansercoer, Katka Novanska, Randy J. Read, Alexandre M.J.J. Bonvin, Bjorn Vergauwen, Kenneth Verstraete, Irina Gutsche, Savvas N. Savvides
Published 2016-11-01

Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis

by Karolina Slowicka, Inmaculada Serramito-Gómez, Emilio Boada-Romero, Arne Martens, Mozes Sze, Ioanna Petta, Hanna K. Vikkula, Riet De Rycke, Eef Parthoens, Saskia Lippens, Savvas N. Savvides, Andy Wullaert, Lars Vereecke, Felipe X. Pimentel-Muiños, Geert van Loo
Published 2019-04-01

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

by Yves Dondelinger, Tom Delanghe, Dario Priem, Meghan A. Wynosky-Dolfi, Daniel Sorobetea, Diego Rojas-Rivera, Piero Giansanti, Ria Roelandt, Julia Gropengiesser, Klaus Ruckdeschel, Savvas N. Savvides, Albert J. R. Heck, Peter Vandenabeele, Igor E. Brodsky, Mathieu J. M. Bertrand
Published 2019-04-01

Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding

by Klaas Yperman, Anna C. Papageorgiou, Romain Merceron, Steven De Munck, Yehudi Bloch, Dominique Eeckhout, Qihang Jiang, Pieter Tack, Rosa Grigoryan, Thomas Evangelidis, Jelle Van Leene, Laszlo Vincze, Peter Vandenabeele, Frank Vanhaecke, Martin Potocký, Geert De Jaeger, Savvas N. Savvides, Konstantinos Tripsianes, Roman Pleskot, Daniel Van Damme
Published 2021-05-01

A CARD9 Founder Mutation Disrupts NF-κB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation

by Marieke De Bruyne, Marieke De Bruyne, Marieke De Bruyne, Levi Hoste, Levi Hoste, Delfien J. Bogaert, Delfien J. Bogaert, Delfien J. Bogaert, Delfien J. Bogaert, Lien Van den Bossche, Lien Van den Bossche, Simon J. Tavernier, Simon J. Tavernier, Eef Parthoens, Eef Parthoens, Mélanie Migaud, Deborah Konopnicki, Jean Cyr Yombi, Bart N. Lambrecht, Bart N. Lambrecht, Sabine van Daele, Ana Karina Alves de Medeiros, Lieve Brochez, Rudi Beyaert, Elfride De Baere, Anne Puel, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Christophe Goffard, Savvas N. Savvides, Savvas N. Savvides, Filomeen Haerynck, Filomeen Haerynck, Jens Staal, Melissa Dullaers, Melissa Dullaers
Published 2018-10-01

DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance

by Flora D’Anna, Laurien Van Dyck, Jieyi Xiong, Hui Zhao, Rebecca V. Berrens, Junbin Qian, Pawel Bieniasz-Krzywiec, Vikas Chandra, Luc Schoonjans, Jason Matthews, Julie De Smedt, Liesbeth Minnoye, Ricardo Amorim, Sepideh Khorasanizadeh, Qian Yu, Liyun Zhao, Marie De Borre, Savvas N. Savvides, M. Celeste Simon, Peter Carmeliet, Wolf Reik, Fraydoon Rastinejad, Massimiliano Mazzone, Bernard Thienpont, Diether Lambrechts
Published 2020-07-01