CRISPR-Cas9: A Revolutionary Tool for Cancer Modelling

by Raul Torres-Ruiz, Sandra Rodriguez-Perales
Published 2015-09-01

CRISPR/Cas9 for Cancer Therapy: Hopes and Challenges

by Marta Martinez-Lage, Pilar Puig-Serra, Pablo Menendez, Raul Torres-Ruiz, Sandra Rodriguez-Perales
Published 2018-11-01

Functional characterization of two enhancers located downstream FOXP2

by Raúl Torres-Ruiz, Antonio Benítez-Burraco, Marta Martínez-Lage, Sandra Rodríguez-Perales, Paloma García-Bellido
Published 2019-05-01

Detection of chromosome instability by interphase FISH in mouse and human tissues

by Raul Torres-Ruiz, Tatiana P. Grazioso, Marta Brandt, Marta Martinez-Lage, Sandra Rodriguez-Perales, Nabil Djouder
Published 2021-09-01

Functional Characterization of a Dual Enhancer/Promoter Regulatory Element Leading Human CD69 Expression

by Jennifer Redondo-Antón, MG Fontela, Laura Notario, Raúl Torres-Ruiz, Sandra Rodríguez-Perales, Elena Lorente, Pilar Lauzurica
Published 2020-10-01

Fast Diffusion Sustains Plasma Membrane Accumulation of Phosphatase of Regenerating Liver-1

by Patricia Castro-Sánchez, Sara Hernández-Pérez, Oscar Aguilar-Sopeña, Rocia Ramírez-Muñoz, Sandra Rodríguez-Perales, Raúl Torres-Ruiz, Pedro Roda-Navarro
Published 2020-12-01

Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling

by Barbara Oldrini, Álvaro Curiel-García, Carolina Marques, Veronica Matia, Özge Uluçkan, Osvaldo Graña-Castro, Raul Torres-Ruiz, Sandra Rodriguez-Perales, Jason T. Huse, Massimo Squatrito
Published 2018-04-01

RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment

by Alvaro Torres-Gomez, Jose Luis Sanchez-Trincado, Víctor Toribio, Raul Torres-Ruiz, Sandra Rodríguez-Perales, María Yáñez-Mó, Pedro A. Reche, Carlos Cabañas, Esther M. Lafuente
Published 2020-05-01

Efficient Recreation of t(11;22) EWSR1-FLI1+ in Human Stem Cells Using CRISPR/Cas9

by Raul Torres-Ruiz, Marta Martinez-Lage, Maria C. Martin, Aida Garcia, Clara Bueno, Julio Castaño, Juan C. Ramirez, Pablo Menendez, Juan C. Cigudosa, Sandra Rodriguez-Perales
Published 2017-05-01

Generation and characterization of a human iPSC cell line expressing inducible Cas9 in the “safe harbor” AAVS1 locus

by Julio Castaño, Clara Bueno, Senda Jiménez-Delgado, Heleia Roca-Ho, Mario F. Fraga, Agustín F. Fernandez, Mahito Nakanishi, Raúl Torres-Ruiz, Sandra Rodríguez-Perales, Pablo Menéndez
Published 2017-05-01

Narrowing the Genetic Causes of Language Dysfunction in the 1q21.1 Microduplication Syndrome

by Antonio Benítez-Burraco, Montserrat Barcos-Martínez, Montserrat Barcos-Martínez, Isabel Espejo-Portero, Isabel Espejo-Portero, Maite Fernández-Urquiza, Raúl Torres-Ruiz, Sandra Rodríguez-Perales, Ma Salud Jiménez-Romero
Published 2018-06-01

Robustness of Catalytically Dead Cas9 Activators in Human Pluripotent and Mesenchymal Stem Cells

by Paolo Petazzi, Raul Torres-Ruiz, Antonella Fidanza, Heleia Roca-Ho, Francisco Gutierrez-Agüera, Julio Castaño, Sandra Rodriguez-Perales, Rafael Díaz de la Guardia, Belén López-Millán, Anna Bigas, Lesley M. Forrester, Clara Bueno, Pablo Menéndez
Published 2020-06-01

Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects

by Juan Miguel Baquero, Carlos Benítez-Buelga, Varshni Rajagopal, Zhao Zhenjun, Raúl Torres-Ruiz, Sarah Müller, Bishoy M. F. Hanna, Olga Loseva, Olov Wallner, Maurice Michel, Sandra Rodríguez-Perales, Helge Gad, Torkild Visnes, Thomas Helleday, Javier Benítez, Ana Osorio
Published 2021-02-01

MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas

by Barbara Oldrini, Nuria Vaquero-Siguero, Quanhua Mu, Paula Kroon, Ying Zhang, Marcos Galán-Ganga, Zhaoshi Bao, Zheng Wang, Hanjie Liu, Jason K. Sa, Junfei Zhao, Hoon Kim, Sandra Rodriguez-Perales, Do-Hyun Nam, Roel G. W. Verhaak, Raul Rabadan, Tao Jiang, Jiguang Wang, Massimo Squatrito
Published 2020-08-01

The IS2 Element Improves Transcription Efficiency of Integration-Deficient Lentiviral Vector Episomes

by Sabina Sánchez-Hernández, Alejandra Gutierrez-Guerrero, Rocío Martín-Guerra, Marina Cortijo-Gutierrez, María Tristán-Manzano, Sandra Rodriguez-Perales, Laura Sanchez, Jose Luis Garcia-Perez, Jesus Chato-Astrain, Ricardo Fernandez-Valades, Ana Belén Carrillo-Galvez, Per Anderson, Rosa Montes, Pedro J. Real, Francisco Martin, Karim Benabdellah
Published 2018-12-01

DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia.

by Sara Alvarez, Javier Suela, Ana Valencia, Agustín Fernández, Mark Wunderlich, Xabier Agirre, Felipe Prósper, José Ignacio Martín-Subero, Alba Maiques, Francesco Acquadro, Sandra Rodriguez Perales, María José Calasanz, Jose Roman-Gómez, Reiner Siebert, James C Mulloy, José Cervera, Miguel Angel Sanz, Manel Esteller, Juan C Cigudosa
Published 2010-08-01

Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis

by Pilar Mur, Richarda M. De Voer, Rubén Olivera-Salguero, Sandra Rodríguez-Perales, Tirso Pons, Fernando Setién, Gemma Aiza, Rafael Valdés-Mas, Angelo Bertini, Marta Pineda, Lilian Vreede, Matilde Navarro, Silvia Iglesias, Sara González, Joan Brunet, Alfonso Valencia, Manel Esteller, Conxi Lázaro, Geert J. P. L. Kops, Miguel Urioste, Xose S. Puente, Gabriel Capellá, Laura Valle
Published 2018-02-01

Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency

by Alvaro Muñoz-López, Damià Romero-Moya, Cristina Prieto, Verónica Ramos-Mejía, Antonio Agraz-Doblas, Ignacio Varela, Marcus Buschbeck, Anna Palau, Xonia Carvajal-Vergara, Alessandra Giorgetti, Anthony Ford, Majlinda Lako, Isabel Granada, Neus Ruiz-Xivillé, Sandra Rodríguez-Perales, Raul Torres-Ruíz, Ronald W. Stam, Jose Luis Fuster, Mario F. Fraga, Mahito Nakanishi, Gianni Cazzaniga, Michela Bardini, Isabel Cobo, Gustavo F. Bayon, Agustin F. Fernandez, Clara Bueno, Pablo Menendez
Published 2016-10-01