Biomarkers for Homologous Recombination Deficiency in Cancer

by Svenja Wagener-Ryczek, Sabine Merkelbach-Bruse, Janna Siemanowski
Published 2021-06-01

Implementing TMB measurement in clinical practice: considerations on assay requirements

by Reinhard Büttner, John W Longshore, Fernando López-Ríos, Sabine Merkelbach-Bruse, Nicola Normanno, Etienne Rouleau, Frédérique Penault-Llorca
Published 2019-02-01

Deep learning for sensitive detection of Helicobacter Pylori in gastric biopsies

by Sebastian Klein, Jacob Gildenblat, Michaele Angelika Ihle, Sabine Merkelbach-Bruse, Ka-Won Noh, Martin Peifer, Alexander Quaas, Reinhard Büttner
Published 2020-12-01

Comparison of in situ and extraction-based methods for the detection of MET amplifications in solid tumors

by Carina Heydt, Ann-Kathrin Becher, Svenja Wagener-Ryczek, Markus Ball, Anne M. Schultheis, Simon Schallenberg, Vanessa Rüsseler, Reinhard Büttner, Sabine Merkelbach-Bruse
Published 2019-01-01

Genomic Characterization of TP53–Wild-Type Esophageal Carcinoma

by Alexander Quaas, Carina Heydt, Florian Gebauer, Hakan Alakus, Heike Loeser, Reinhard Buettner, Axel Hillmer, Christiane Bruns, Sabine Merkelbach-Bruse, Thomas Zander, Peter Frommolt
Published 2019-01-01

Analysis of tumor mutational burden: correlation of five large gene panels with whole exome sequencing

by Carina Heydt, Jan Rehker, Roberto Pappesch, Theresa Buhl, Markus Ball, Udo Siebolts, Anja Haak, Philipp Lohneis, Reinhard Büttner, Axel M. Hillmer, Sabine Merkelbach-Bruse
Published 2020-07-01

Comparison of pre-analytical FFPE sample preparation methods and their impact on massively parallel sequencing in routine diagnostics.

by Carina Heydt, Jana Fassunke, Helen Künstlinger, Michaela Angelika Ihle, Katharina König, Lukas Carl Heukamp, Hans-Ulrich Schildhaus, Margarete Odenthal, Reinhard Büttner, Sabine Merkelbach-Bruse
Published 2014-01-01

Nuclear hBD-1 accumulation in malignant salivary gland tumours

by Merkelbach-Bruse S, Jepsen S, Allam JP, Martini M, Bergé S, Reich R, Götz W, Dommisch H, Pantelis A, Wenghoefer M, Fischer HP, Novak N, Winter J
Published 2008-10-01

Managing Difficulties of Microsatellite Instability Testing in Endometrial Cancer-Limitations and Advantages of Four Different PCR-Based Approaches

by Janna Siemanowski, Birgid Schömig-Markiefka, Theresa Buhl, Anja Haak, Udo Siebolts, Wolfgang Dietmaier, Norbert Arens, Nina Pauly, Beyhan Ataseven, Reinhard Büttner, Sabine Merkelbach-Bruse
Published 2021-03-01

MET gene copy number alterations and expression of MET and hepatocyte growth factor are potential biomarkers in angiosarcomas and undifferentiated pleomorphic sarcomas.

by Katja Schmitz, Hartmut Koeppen, Elke Binot, Jana Fassunke, Helen Künstlinger, Michaela A Ihle, Carina Heydt, Eva Wardelmann, Reinhard Büttner, Sabine Merkelbach-Bruse, Josef Rüschoff, Hans-Ulrich Schildhaus
Published 2015-01-01

Mutational spectrum of acquired resistance to reversible versus irreversible EGFR tyrosine kinase inhibitors

by Svenja Wagener-Ryczek, Carina Heydt, Juliane Süptitz, Sebastian Michels, Markus Falk, Christina Alidousty, Jana Fassunke, Michaela Angelika Ihle, Markus Tiemann, Lukas Heukamp, Jürgen Wolf, Reinhard Büttner, Sabine Merkelbach-Bruse
Published 2020-05-01

Pitfalls in mutational testing and reporting of common <it>KIT </it>and <it>PDGFRA </it>mutations in gastrointestinal stromal tumors

by Penzel Roland, Mechtersheimer Gunhild, Krohn Antje, Kitz Julia, Haller Florian, Gaumann Andreas, Füzesi Laszlo, Dietmaier Wolfgang, Merkelbach-Bruse Sabine, Schildhaus Hans-Ulrich, Schneider-Stock Regine, Simon Ronald, Wardelmann Eva
Published 2010-07-01

Expression of cell cycle regulators and frequency of TP53 mutations in high risk gastrointestinal stromal tumors prior to adjuvant imatinib treatment.

by Michaela Angelika Ihle, Sebastian Huss, Wiebke Jeske, Wolfgang Hartmann, Sabine Merkelbach-Bruse, Hans-Ulrich Schildhaus, Reinhard Büttner, Harri Sihto, Kirsten Sundby Hall, Mikael Eriksson, Peter Reichardt, Heikki Joensuu, Eva Wardelmann
Published 2018-01-01

Alterations in ERBB2 and BRCA and microsatellite instability as new personalized treatment options in small bowel carcinoma

by Alexander Quaas, Carina Heydt, Dirk Waldschmidt, Hakan Alakus, Thomas Zander, Tobias Goeser, Philipp Kasper, Christiane Bruns, Anna Brunn, Wilfried Roth, Nils Hartmann, Anne Bunck, Matthias Schmidt, Reinhard Buettner, Sabine Merkelbach-Bruse
Published 2019-02-01

Therapy susceptible germline-related BRCA 1-mutation in a case of metastasized mixed adeno-neuroendocrine carcinoma (MANEC) of the small bowel

by A. Quaas, D. Waldschmidt, H. Alakus, T. Zander, C. Heydt, T. Goeser, M. Daheim, P. Kasper, P. Plum, C. Bruns, A. Brunn, W. Roth, N. Hartmann, A. Bunck, M. Schmidt, H. Göbel, L. Tharun, R. Buettner, S. Merkelbach-Bruse
Published 2018-05-01

ALK G1269A mutation as a potential mechanism of acquired resistance to crizotinib in an ALK-rearranged inflammatory myofibroblastic tumor

by Sebastian Y. F. Michels, Andreas H. Scheel, Thomas Wündisch, Johannes M. Heuckmann, Roopika Menon, Michael Puesken, Carsten Kobe, Helen Pasternack, Carina Heydt, Matthias Scheffler, Rieke Fischer, Anne M. Schultheis, Sabine Merkelbach-Bruse, Lukas Heukamp, Reinhard Büttner, Jürgen Wolf
Published 2017-03-01

Somatic alterations in circulating cell-free DNA of oesophageal carcinoma patients during primary staging are indicative for post-surgical tumour recurrence

by Helen Pasternack, Jana Fassunke, Patrick Sven Plum, Seung-Hun Chon, Daniel Alexander Hescheler, Asmae Gassa, Sabine Merkelbach-Bruse, Christiane Josephine Bruns, Sven Perner, Michael Hallek, Reinhard Büttner, Elfriede Bollschweiler, Arnulf Heinrich Hölscher, Alexander Quaas, Thomas Zander, Jonathan Weiss, Hakan Alakus
Published 2018-10-01

Detection of gene fusions using targeted next-generation sequencing: a comparative evaluation

by Carina Heydt, Christina B. Wölwer, Oscar Velazquez Camacho, Svenja Wagener-Ryczek, Roberto Pappesch, Janna Siemanowski, Jan Rehker, Florian Haller, Abbas Agaimy, Karl Worm, Thomas Herold, Nicole Pfarr, Wilko Weichert, Thomas Kirchner, Andreas Jung, Jörg Kumbrink, Wolfgang Goering, Irene Esposito, Reinhard Buettner, Axel M. Hillmer, Sabine Merkelbach-Bruse
Published 2021-02-01

Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy

by Martin Thelen, Kerstin Wennhold, Jonas Lehmann, Maria Garcia-Marquez, Sebastian Klein, Elena Kochen, Philipp Lohneis, Axel Lechner, Svenja Wagener-Ryczek, Patrick Sven Plum, Oscar Velazquez Camacho, David Pfister, Fabian Dörr, Matthias Heldwein, Khosro Hekmat, Dirk Beutner, Jens Peter Klussmann, Fabinshy Thangarajah, Dominik Ratiu, Wolfram Malter, Sabine Merkelbach-Bruse, Christiane Josephine Bruns, Alexander Quaas, Michael von Bergwelt-Baildon, Hans A. Schlößer
Published 2021-06-01

Sorafenib and everolimus in patients with advanced solid tumors and KRAS‐mutated NSCLC: A phase I trial with early pharmacodynamic FDG‐PET assessment

by Lucia Nogova, Christian Mattonet, Matthias Scheffler, Max Taubert, Masyar Gardizi, Martin L. Sos, Sebastian Michels, Rieke N. Fischer, Meike Limburg, Diana S.Y. Abdulla, Thorsten Persigehl, Carsten Kobe, Sabine Merkelbach‐Bruse, Jeremy Franklin, Heiko Backes, Roland Schnell, Dirk Behringer, Britta Kaminsky, Martina Eichstaedt, Christoph Stelzer, Martina Kinzig, Fritz Sörgel, Yingying Tian, Lisa Junge, Ahmed A. Suleiman, Sebastian Frechen, Dennis Rokitta, Dongsheng Ouyang, Uwe Fuhr, Reinhard Buettner, Jürgen Wolf
Published 2020-07-01