Asparagine Deprivation Causes a Reversible Inhibition of Human Cytomegalovirus Acute Virus Replication

by Chen-Hsuin Lee, Samantha Griffiths, Paul Digard, Nhan Pham, Manfred Auer, Juergen Haas, Finn Grey
Published 2019-10-01

Expression of HIV-1 Vpu leads to loss of the viral restriction factor CD317/Tetherin from lipid rafts and its enhanced lysosomal degradation.

by Ruth Rollason, Katie Dunstan, Peter G Billcliff, Paul Bishop, Paul Gleeson, Helen Wise, Paul Digard, George Banting
Published 2013-01-01

Engineered Recombinant Single Chain Variable Fragment of Monoclonal Antibody Provides Protection to Chickens Infected with H9N2 Avian Influenza

by Deimante Lukosaityte, Jean-Remy Sadeyen, Angita Shrestha, Joshua E. Sealy, Sushant Bhat, Pengxiang Chang, Paul Digard, Munir Iqbal
Published 2020-03-01

Effects of mutations in the effector domain of influenza A virus NS1 protein

by Carina F. Pereira, Helen M. Wise, Dominic Kurian, Rute M. Pinto, Maria J. Amorim, Andrew C. Gill, Paul Digard
Published 2018-09-01

Precision cut lung slices: a novel versatile tool to examine host–pathogen interaction in the chicken lung

by Karen Jane Bryson, Damien Garrido, Marco Esposito, Gerry McLachlan, Paul Digard, Catherine Schouler, Rodrigo Guabiraba, Sascha Trapp, Lonneke Vervelde
Published 2020-01-01

Face coverings and respiratory tract droplet dispersion

by Lucia Bandiera, Geethanjali Pavar, Gabriele Pisetta, Shuji Otomo, Enzo Mangano, Jonathan R. Seckl, Paul Digard, Emanuela Molinari, Filippo Menolascina, Ignazio Maria Viola
Published 2020-12-01

Survival of influenza A(H1N1) on materials found in households: implications for infection control.

by Jane S Greatorex, Paul Digard, Martin D Curran, Robert Moynihan, Harrison Wensley, Tim Wreghitt, Harsha Varsani, Fayna Garcia, Joanne Enstone, Jonathan S Nguyen-Van-Tam
Published 2011-01-01

Effectiveness of common household cleaning agents in reducing the viability of human influenza A/H1N1.

by Jane S Greatorex, Rosanna F Page, Martin D Curran, Paul Digard, Joanne E Enstone, Tim Wreghitt, Penny P Powell, Darren W Sexton, Roberto Vivancos, Jonathan S Nguyen-Van-Tam
Published 2010-02-01

Comparison of the efficacy of a commercial inactivated influenza A/H1N1/pdm09 virus (pH1N1) vaccine and two experimental M2e-based vaccines against pH1N1 challenge in the growing p...

by Tanja Opriessnig, Phillip C Gauger, Priscilla F Gerber, Alessandra M M G Castro, Huigang Shen, Lita Murphy, Paul Digard, Patrick G Halbur, Ming Xia, Xi Jiang, Ming Tan
Published 2018-01-01

Modelling the Structure and Dynamics of Biological Pathways.

by Laura O'Hara, Alessandra Livigni, Thanos Theo, Benjamin Boyer, Tim Angus, Derek Wright, Sz-Hau Chen, Sobia Raza, Mark W Barnett, Paul Digard, Lee B Smith, Tom C Freeman
Published 2016-08-01

Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection

by Eleanor Gaunt, Helen M Wise, Huayu Zhang, Lian N Lee, Nicky J Atkinson, Marlynne Quigg Nicol, Andrew J Highton, Paul Klenerman, Philippa M Beard, Bernadette M Dutia, Paul Digard, Peter Simmonds
Published 2016-02-01

A chicken bioreactor for efficient production of functional cytokines

by Lissa R. Herron, Clare Pridans, Matthew L. Turnbull, Nikki Smith, Simon Lillico, Adrian Sherman, Hazel J. Gilhooley, Martin Wear, Dominic Kurian, Grigorios Papadakos, Paul Digard, David A. Hume, Andrew C. Gill, Helen M. Sang
Published 2018-12-01

The environmental deposition of influenza virus from patients infected with influenza A(H1N1)pdm09: Implications for infection prevention and control

by Benjamin Killingley, Jane Greatorex, Paul Digard, Helen Wise, Fayna Garcia, Harsha Varsani, Simon Cauchemez, Joanne E. Enstone, Andrew Hayward, Martin D. Curran, Robert C. Read, Wei S. Lim, Karl G. Nicholson, Jonathan S. Nguyen-Van-Tam
Published 2016-05-01

Staphylococcus aureus Lipase 1 Enhances Influenza A Virus Replication

by Mariya I. Goncheva, Carina Conceicao, Stephen W. Tuffs, Hui-Min Lee, Marlynne Quigg-Nicol, Ian Bennet, Fiona Sargison, Amy C. Pickering, Saira Hussain, Andrew C. Gill, Bernadette M. Dutia, Paul Digard, J. Ross Fitzgerald
Published 2020-07-01

Identification of a novel splice variant form of the influenza A virus M2 ion channel with an antigenically distinct ectodomain.

by Helen M Wise, Edward C Hutchinson, Brett W Jagger, Amanda D Stuart, Zi H Kang, Nicole Robb, Louis M Schwartzman, John C Kash, Ervin Fodor, Andrew E Firth, Julia R Gog, Jeffery K Taubenberger, Paul Digard
Published 2012-01-01

Constitutive TRIM22 Expression in the Respiratory Tract Confers a Pre-Existing Defence Against Influenza A Virus Infection

by Matthew Charman, Matthew Charman, Matthew Charman, Steven McFarlane, Joanna K. Wojtus, Elizabeth Sloan, Rebecca Dewar, Gail Leeming, Mohammed Al-Saadi, Mohammed Al-Saadi, Laura Hunter, Miles W. Carroll, James P. Stewart, Paul Digard, Edward Hutchinson, Chris Boutell
Published 2021-09-01

STING nuclear partners contribute to innate immune signaling responses

by Charles R. Dixon, Poonam Malik, Jose I. de las Heras, Natalia Saiz-Ros, Flavia de Lima Alves, Mark Tingey, Eleanor Gaunt, A. Christine Richardson, David A. Kelly, Martin W. Goldberg, Greg J. Towers, Weidong Yang, Juri Rappsilber, Paul Digard, Eric C. Schirmer
Published 2021-09-01

Face Coverings, Aerosol Dispersion and Mitigation of Virus Transmission Risk

by Ignazio Maria Viola, Brian Peterson, Gabriele Pisetta, Geethanjali Pavar, Hibbah Akhtar, Filippo Menoloascina, Enzo Mangano, Katherine E. Dunn, Roman Gabl, Alex Nila, Emanuela Molinari, Cathal Cummins, Gerard Thompson, Tsz-Yan Milly Lo, Fiona C. Denison, Paul Digard, Omair Malik, Mark J. G. Dunn, Catherine M. McDougall, Felicity V. Mehendale
Published 2021-01-01

Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

by Bo Li, Sara M. Clohisey, Bing Shao Chia, Bo Wang, Ang Cui, Thomas Eisenhaure, Lawrence D. Schweitzer, Paul Hoover, Nicholas J. Parkinson, Aharon Nachshon, Nikki Smith, Tim Regan, David Farr, Michael U. Gutmann, Syed Irfan Bukhari, Andrew Law, Maya Sangesland, Irit Gat-Viks, Paul Digard, Shobha Vasudevan, Daniel Lingwood, David H. Dockrell, John G. Doench, J. Kenneth Baillie, Nir Hacohen
Published 2020-01-01