The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0.

by Caroline E Lilley, Mira S Chaurushiya, Chris Boutell, Roger D Everett, Matthew D Weitzman
Published 2011-06-01

Reactivation of Herpes Simplex Virus (HSV) from Latency in Response to Neuronal Hyperexcitability

by Sean Cuddy, Austin Schinlever, Sara Dochnal, Jon Suzich, Mina Farah, Chris Boutell, Anna Ruth Cliffe
Published 2020-06-01

The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells.

by Samuel Stokes, Floriane Almire, Michael H Tatham, Steven McFarlane, Peter Mertens, Emilie Pondeville, Chris Boutell
Published 2020-12-01

A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defence.

by Chris Boutell, Delphine Cuchet-Lourenço, Emilia Vanni, Anne Orr, Mandy Glass, Steven McFarlane, Roger D Everett
Published 2011-09-01

Correction: Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.

by Thamir Alandijany, Ashley P E Roberts, Kristen L Conn, Colin Loney, Steven McFarlane, Anne Orr, Chris Boutell
Published 2018-02-01

SUMO pathway dependent recruitment of cellular repressors to herpes simplex virus type 1 genomes.

by Delphine Cuchet-Lourenço, Chris Boutell, Vera Lukashchuk, Kyle Grant, Amanda Sykes, Jill Murray, Anne Orr, Roger D Everett
Published 2011-07-01

Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.

by Thamir Alandijany, Ashley P E Roberts, Kristen L Conn, Colin Loney, Steven McFarlane, Anne Orr, Chris Boutell
Published 2018-01-01

Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1

by Sean R Cuddy, Austin R Schinlever, Sara Dochnal, Philip V Seegren, Jon Suzich, Parijat Kundu, Taylor K Downs, Mina Farah, Bimal N Desai, Chris Boutell, Anna R Cliffe
Published 2020-12-01

The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.

by Steven McFarlane, Anne Orr, Ashley P E Roberts, Kristen L Conn, Victor Iliev, Colin Loney, Ana da Silva Filipe, Katherine Smollett, Quan Gu, Neil Robertson, Peter D Adams, Taranjit Singh Rai, Chris Boutell
Published 2019-03-01

Constitutive TRIM22 Expression in the Respiratory Tract Confers a Pre-Existing Defence Against Influenza A Virus Infection

by Matthew Charman, Matthew Charman, Matthew Charman, Steven McFarlane, Joanna K. Wojtus, Elizabeth Sloan, Rebecca Dewar, Gail Leeming, Mohammed Al-Saadi, Mohammed Al-Saadi, Laura Hunter, Miles W. Carroll, James P. Stewart, Paul Digard, Edward Hutchinson, Chris Boutell
Published 2021-09-01

A systematic analysis of host factors reveals a Med23-interferon-λ regulatory axis against herpes simplex virus type 1 replication.

by Samantha J Griffiths, Manfred Koegl, Chris Boutell, Helen L Zenner, Colin M Crump, Francesca Pica, Orland Gonzalez, Caroline C Friedel, Gerald Barry, Kim Martin, Marie H Craigon, Rui Chen, Lakshmi N Kaza, Even Fossum, John K Fazakerley, Stacey Efstathiou, Antonio Volpi, Ralf Zimmer, Peter Ghazal, Jürgen Haas
Published 2013-01-01