Cancer cells with trapped nuclei cut their way through the extracellular matrix

by Emmanuel Dornier, Jim C. Norman
Published 2018-09-01

P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments.

by Andrew D Campbell, Samuel Lawn, Lynn C McGarry, Heidi C Welch, Bradford W Ozanne, Jim C Norman
Published 2013-01-01

Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration

by Elena Rainero, Jonathan D. Howe, Patrick T. Caswell, Nigel B. Jamieson, Kurt Anderson, David R. Critchley, Laura Machesky, Jim C. Norman
Published 2015-01-01

FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells.

by Juan Pablo Macagno, Jesica Diaz Vera, Yachuan Yu, Iain MacPherson, Emma Sandilands, Ruth Palmer, Jim C Norman, Margaret Frame, Marcos Vidal
Published 2014-03-01

Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.

by Donatella Valdembri, Patrick T Caswell, Kurt I Anderson, Juliane P Schwarz, Ireen König, Elena Astanina, Francesca Caccavari, Jim C Norman, Martin J Humphries, Federico Bussolino, Guido Serini
Published 2009-01-01

Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion

by Christine Gundry, Sergi Marco, Elena Rainero, Bryan Miller, Emmanuel Dornier, Louise Mitchell, Patrick T. Caswell, Andrew D. Campbell, Anna Hogeweg, Owen J. Sansom, Jennifer P. Morton, Jim C. Norman
Published 2017-03-01

The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma

by Joanna Birch, Cassie J. Clarke, Andrew D. Campbell, Kirsteen Campbell, Louise Mitchell, Dritan Liko, Gabriela Kalna, Douglas Strathdee, Owen J. Sansom, Matthew Neilson, Karen Blyth, Jim C. Norman
Published 2016-10-01

RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

by Máté Nászai, Karen Bellec, Yachuan Yu, Alvaro Román-Fernández, Emma Sandilands, Joel Johansson, Andrew D Campbell, Jim C Norman, Owen J Sansom, David M Bryant, Julia B Cordero
Published 2021-06-01

Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells

by Emmanuel Dornier, Nicolas Rabas, Louise Mitchell, David Novo, Sandeep Dhayade, Sergi Marco, Gillian Mackay, David Sumpton, Maria Pallares, Colin Nixon, Karen Blyth, Iain R. Macpherson, Elena Rainero, Jim C. Norman
Published 2017-12-01

Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane

by Vinaya Phatak, Yannick von Grabowiecki, Justyna Janus, Leah Officer, Caron Behan, Lydia Aschauer, Lucia Pinon, Hannah Mackay, Sara Zanivan, Jim C. Norman, Michael Kelly, John Le Quesne, Patricia A. J. Muller
Published 2021-02-01

The diacylglycerol kinase α/atypical PKC/β1 integrin pathway in SDF-1α mammary carcinoma invasiveness.

by Elena Rainero, Cristina Cianflone, Paolo Ettore Porporato, Federica Chianale, Valeria Malacarne, Valentina Bettio, Elisa Ruffo, Michele Ferrara, Fabio Benecchia, Daniela Capello, Wolfgang Paster, Irene Locatelli, Alessandra Bertoni, Nicoletta Filigheddu, Fabiola Sinigaglia, Jim C Norman, Gianluca Baldanzi, Andrea Graziani
Published 2014-01-01

Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels

by David Novo, Nikki Heath, Louise Mitchell, Giuseppina Caligiuri, Amanda MacFarlane, Dide Reijmer, Laura Charlton, John Knight, Monika Calka, Ewan McGhee, Emmanuel Dornier, David Sumpton, Susan Mason, Arnaud Echard, Kerstin Klinkert, Judith Secklehner, Flore Kruiswijk, Karen Vousden, Iain R. Macpherson, Karen Blyth, Peter Bailey, Huabing Yin, Leo M. Carlin, Jennifer Morton, Sara Zanivan, Jim C. Norman
Published 2018-11-01

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity

by Juan R. Hernandez-Fernaud, Elena Ruengeler, Andrea Casazza, Lisa J. Neilson, Ellie Pulleine, Alice Santi, Shehab Ismail, Sergio Lilla, Sandeep Dhayade, Iain R. MacPherson, Iain McNeish, Darren Ennis, Hala Ali, Fernanda G. Kugeratski, Heba Al Khamici, Maartje van den Biggelaar, Peter V.E. van den Berghe, Catherine Cloix, Laura McDonald, David Millan, Aoisha Hoyle, Anna Kuchnio, Peter Carmeliet, Stella M. Valenzuela, Karen Blyth, Huabing Yin, Massimiliano Mazzone, Jim C. Norman, Sara Zanivan
Published 2017-02-01