Gene editing of PKLR gene in human hematopoietic progenitors through 5' and 3' UTR modified TALEN mRNA.

by Oscar Quintana-Bustamante, Sara Fañanas-Baquero, Israel Orman, Raul Torres, Philippe Duchateau, Laurent Poirot, Agnès Gouble, Juan A Bueren, Jose C Segovia
Published 2019-01-01

Cell fusion reprogramming leads to a specific hepatic expression pattern during mouse bone marrow derived hepatocyte formation in vivo.

by Oscar Quintana-Bustamante, Esther Grueso, Ramon Garcia-Escudero, Elvira Arza, Alberto Alvarez-Barrientos, Isabel Fabregat, Maria Garcia-Bravo, Nestor W Meza, Jose C Segovia
Published 2012-01-01

The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy

by David García-Bernal, David García-Bernal, Mariano García-Arranz, Mariano García-Arranz, Rosa M. Yáñez, Rosa M. Yáñez, Rosa M. Yáñez, Rosario Hervás-Salcedo, Rosario Hervás-Salcedo, Rosario Hervás-Salcedo, Alfonso Cortés, Alfonso Cortés, María Fernández-García, María Fernández-García, María Fernández-García, Miriam Hernando-Rodríguez, Miriam Hernando-Rodríguez, Miriam Hernando-Rodríguez, Óscar Quintana-Bustamante, Óscar Quintana-Bustamante, Óscar Quintana-Bustamante, Juan A. Bueren, Juan A. Bueren, Juan A. Bueren, Damián García-Olmo, Damián García-Olmo, Jose M. Moraleda, Jose M. Moraleda, José C. Segovia, José C. Segovia, José C. Segovia, Agustín G. Zapata, Agustín G. Zapata
Published 2021-03-01

Enhanced anti-inflammatory effects of mesenchymal stromal cells mediated by the transient ectopic expression of CXCR4 and IL10

by Rosario Hervás-Salcedo, María Fernández-García, Miriam Hernando-Rodríguez, Oscar Quintana-Bustamante, Jose-Carlos Segovia, Marcio Alvarez-Silva, Mariano García-Arranz, Pablo Minguez, Victoria del Pozo, Marta Rodríguez de Alba, Damián García-Olmo, Carmen Ayuso, María Luisa Lamana, Juan A. Bueren, Rosa María Yañez
Published 2021-02-01

Clinically relevant gene editing in hematopoietic stem cells for the treatment of pyruvate kinase deficiency

by Sara Fañanas-Baquero, Oscar Quintana-Bustamante, Daniel P. Dever, Omaira Alberquilla, Rebeca Sanchez-Dominguez, Joab Camarena, Isabel Ojeda-Perez, Mercedes Dessy-Rodriguez, Rolf Turk, Mollie S. Schubert, Annalisa Lattanzi, Liwen Xu, Jose L. Lopez-Lorenzo, Paola Bianchi, Juan A. Bueren, Mark A. Behlke, Matthew Porteus, Jose-Carlos Segovia
Published 2021-09-01

Preclinical studies of efficacy thresholds and tolerability of a clinically ready lentiviral vector for pyruvate kinase deficiency treatment

by Susana Navarro, Oscar Quintana-Bustamante, Rebeca Sanchez-Dominguez, Sergio Lopez-Manzaneda, Isabel Ojeda-Perez, Aida Garcia-Torralba, Omaira Alberquilla, Kenneth Law, Brian C. Beard, Antonella Bastone, Michael Rothe, Mariela Villanueva, Juan C. Ramirez, Sara Fañanas-Baquero, Virginia Nieto-Romero, Andrea Molinos-Vicente, Sonia Gutierrez, Eileen Nicoletti, María García-Bravo, Juan A. Bueren, Jonathan D. Schwartz, Jose-Carlos Segovia
Published 2021-09-01

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells

by Zita Garate, Oscar Quintana-Bustamante, Ana M. Crane, Emmanuel Olivier, Laurent Poirot, Roman Galetto, Penelope Kosinski, Collin Hill, Charles Kung, Xabi Agirre, Israel Orman, Laura Cerrato, Omaira Alberquilla, Fatima Rodriguez-Fornes, Noemi Fusaki, Felix Garcia-Sanchez, Tabita M. Maia, Maria L. Ribeiro, Julian Sevilla, Felipe Prosper, Shengfang Jin, Joanne Mountford, Guillermo Guenechea, Agnes Gouble, Juan A. Bueren, Brian R. Davis, Jose C. Segovia
Published 2015-12-01