Enhanced Follicular Dendritic Cell-B Cell Interaction in HIV and SIV Infections and its Potential Role in Polyclonal B Cell Activation

by Yvonne J. Rosenberg, Mark. G. Lewis, Marie H. Kosco-Vilbois
Published 1998-01-01

Significant Depletion of CD4+ T Cells Occurs in the Oral Mucosa during Simian Immunodeficiency Virus Infection with the Infected CD4+ T Cell Reservoir Continuing to Persist in the...

by Jeffy George, Wendeline Wagner, Mark G. Lewis, Joseph J. Mattapallil
Published 2015-01-01

Rhesus macaque lymph node PD-1(hi)CD4+ T cells express high levels of CXCR5 and IL-21 and display a CCR7(lo)ICOS+Bcl6+ T-follicular helper (Tfh) cell phenotype.

by Olusegun O Onabajo, Jeffy George, Mark G Lewis, Joseph J Mattapallil
Published 2013-01-01

SIV Infection of Lung Macrophages.

by Yue Li, Guobin Kang, Lijie Duan, Wuxun Lu, Michael G Katze, Mark G Lewis, Ashley T Haase, Qingsheng Li
Published 2015-01-01

DNA encoding an HIV-1 Gag/human lysosome-associated membrane protein-1 chimera elicits a broad cellular and humoral immune response in Rhesus macaques.

by Priya Chikhlikar, Luciana Barros de Arruda, Milton Maciel, Peter Silvera, Mark G Lewis, J Thomas August, Ernesto T A Marques
Published 2006-12-01

Simultaneous Coinfection of Macaques with Zika and Dengue Viruses Does not Enhance Acute Plasma Viremia but Leads to Activation of Monocyte Subsets and Biphasic Release of Pro-infl...

by William G. Valiant, Mary J. Mattapallil, Stephen Higgs, Yan-Jang S. Huang, Dana L. Vanlandingham, Mark G. Lewis, Joseph J. Mattapallil
Published 2019-05-01

Protection against SHIV Challenge by Subcutaneous Administration of the Plant-Derived PGT121 Broadly Neutralizing Antibody in Macaques.

by Yvonne J Rosenberg, David C Montefiori, Celia C LaBranche, Mark G Lewis, Markus Sack, Jonathan P Lees, Xiaoming Jiang
Published 2016-01-01

Introduction of the YTE mutation into the non-immunogenic HIV bnAb PGT121 induces anti-drug antibodies in macaques.

by Yvonne J Rosenberg, George K Lewis, David C Montefiori, Celia C LaBranche, Mark G Lewis, Lori A Urban, Jonathan P Lees, Lingjun Mao, Xiaoming Jiang
Published 2019-01-01

A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model.

by Iart Luca Shytaj, Sandro Norelli, Barbara Chirullo, Alessandro Della Corte, Matt Collins, Jake Yalley-Ogunro, Jack Greenhouse, Nunzio Iraci, Edward P Acosta, Maria Letizia Barreca, Mark G Lewis, Andrea Savarino
Published 2012-01-01

Vesicular stomatitis virus-based ebola vaccine is well-tolerated and protects immunocompromised nonhuman primates.

by Thomas W Geisbert, Kathleen M Daddario-Dicaprio, Mark G Lewis, Joan B Geisbert, Allen Grolla, Anders Leung, Jason Paragas, Lennox Matthias, Mark A Smith, Steven M Jones, Lisa E Hensley, Heinz Feldmann, Peter B Jahrling
Published 2008-11-01

Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection.

by Joseph A Fraietta, Yvonne M Mueller, Guibin Yang, Alina C Boesteanu, Donald T Gracias, Duc H Do, Jennifer L Hope, Noshin Kathuria, Shannon E McGettigan, Mark G Lewis, Luis D Giavedoni, Jeffrey M Jacobson, Peter D Katsikis
Published 2013-01-01

Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy

by James B. Whitney, So-Yon Lim, Christa E. Osuna, Jessica L. Kublin, Elsa Chen, Gyeol Yoon, Po-Ting Liu, Peter Abbink, Erica N. Borducci, Alison Hill, Mark G. Lewis, Romas Geleziunas, Merlin L. Robb, Nelson L. Michael, Dan H. Barouch
Published 2018-12-01

Correlates of Protection Against SIVmac251 Infection in Rhesus Macaques Immunized With Chimpanzee-Derived Adenovirus Vectors

by Steven Tuyishime, Larissa H. Haut, Raj K. Kurupati, James M. Billingsley, Diane Carnathan, Sailaja Gangahara, Tiffany M. Styles, ZhiQuan Xiang, Yan Li, Malte Zopfs, Qin Liu, XiangYang Zhou, Mark G. Lewis, Rama R. Amara, Steven Bosinger, Guido Silvestri, Hildegund C.J. Ertl
Published 2018-05-01

A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates.

by Karthik Mallilankaraman, Devon J Shedlock, Huihui Bao, Omkar U Kawalekar, Paolo Fagone, Aarthi A Ramanathan, Bernadette Ferraro, Jennifer Stabenow, Paluru Vijayachari, Senthil G Sundaram, Nagarajan Muruganandam, Gopalsamy Sarangan, Padma Srikanth, Amir S Khan, Mark G Lewis, J Joseph Kim, Niranjan Y Sardesai, Karuppiah Muthumani, David B Weiner
Published 2011-01-01

Long-term programming of antigen-specific immunity from gene expression signatures in the PBMC of rhesus macaques immunized with an SIV DNA vaccine.

by Sarah E Belisle, Jiangmei Yin, Devon J Shedlock, Anlan Dai, Jian Yan, Lauren Hirao, Michele A Kutzler, Mark G Lewis, Hanne Andersen, Simon M Lank, Julie A Karl, David H O'Connor, Amir Khan, Niranjan Sardesai, Jean Chang, Lauri Aicher, Robert E Palermo, David B Weiner, Michael G Katze, Jean Boyer
Published 2011-01-01

Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques

by Anthony M. Cadena, John D. Ventura, Peter Abbink, Erica N. Borducchi, Hubert Tuyishime, Noe B. Mercado, Victoria Walker-Sperling, Mazuba Siamatu, Po-Ting Liu, Abishek Chandrashekar, Joseph P. Nkolola, Katherine McMahan, Nicole Kordana, Venous Hamza, Esther A. Bondzie, Emily Fray, Mithra Kumar, Stephanie Fischinger, Sally A. Shin, Mark G. Lewis, Robert F. Siliciano, Galit Alter, Dan H. Barouch
Published 2021-03-01

Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

by Kevin O. Saunders, Norbert Pardi, Robert Parks, Sampa Santra, Zekun Mu, Laura Sutherland, Richard Scearce, Maggie Barr, Amanda Eaton, Giovanna Hernandez, Derrick Goodman, Michael J. Hogan, Istvan Tombacz, David N. Gordon, R. Wes Rountree, Yunfei Wang, Mark G. Lewis, Theodore C. Pierson, Chris Barbosa, Ying Tam, Xiaoying Shen, Guido Ferrari, Georgia D. Tomaras, David C. Montefiori, Drew Weissman, Barton F. Haynes
Published 2021-04-01

Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization

by Qifeng Han, Todd Bradley, Wilton B. Williams, Derek W. Cain, David C. Montefiori, Kevin O. Saunders, Robert J. Parks, Regina W. Edwards, Guido Ferrari, Olaf Mueller, Xiaoying Shen, Kevin J. Wiehe, Steven Reed, Christopher B. Fox, Wes Rountree, Nathan A. Vandergrift, Yunfei Wang, Laura L. Sutherland, Sampa Santra, M. Anthony Moody, Sallie R. Permar, Georgia D. Tomaras, Mark G. Lewis, Koen K.A. Van Rompay, Barton F. Haynes
Published 2020-02-01

Immune checkpoint modulation enhances HIV-1 antibody induction

by Todd Bradley, Masayuki Kuraoka, Chen-Hao Yeh, Ming Tian, Huan Chen, Derek W. Cain, Xuejun Chen, Cheng Cheng, Ali H. Ellebedy, Robert Parks, Maggie Barr, Laura L. Sutherland, Richard M. Scearce, Cindy M. Bowman, Hilary Bouton-Verville, Sampa Santra, Kevin Wiehe, Mark G. Lewis, Ane Ogbe, Persephone Borrow, David Montefiori, Mattia Bonsignori, M. Anthony Moody, Laurent Verkoczy, Kevin O. Saunders, Rafi Ahmed, John R. Mascola, Garnett Kelsoe, Frederick W. Alt, Barton F. Haynes
Published 2020-02-01