Akt signaling Animals Article Cell Line DEPTOR protein, human Intracellular Signaling Peptides and Proteins Mechanistic Target of Rapamycin Complex 1 Mechanistic Target of Rapamycin Complex 2 OUT domain containing protein 7B Phosphatidylinositol 3-Kinases Reproducibility of Results Signal Transduction TOR Serine-Threonine Kinases animal breast cancer cell cell recognition cell line chemistry controlled study data analysis deubiquitinase deubiquitination encapsulation enzyme activity feedback system human human cell in vitro study insulin receptor substrate 1 insulin receptor substrate 2