human cell human 416 Article 360 controlled study 320 Humans 267 female 153 unclassified drug 150 male 143 metabolism 134 adult 124 nonhuman 119 genetics 115 in vitro study 109 human tissue 95 Female 88 protein expression 88 pathology 86 Male 84 gene expression 81 Animals 79 major clinical study 77 animal 76 cell proliferation 76 mouse 72 article 70 apoptosis 66 middle aged 64 Cell Line, Tumor 62 animal experiment 59 tumor cell line 59