Tumor cell death by pattern-sensing of exogenous RNA: Tumor cell TLR3 directly induces necroptosis by poly(I:C) in vivo, independent of immune effector-mediated tumor shrinkage

by Hiromi Takaki, Hiroaki Shime, Misako Matsumoto, Tsukasa Seya
Published 2017-10-01

Toll-Like Receptor 3 Signal in Dendritic Cells Benefits Cancer Immunotherapy

by Misako Matsumoto, Yohei Takeda, Megumi Tatematsu, Tsukasa Seya
Published 2017-12-01

A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.

by Hiroyuki Oshiumi, Moeko Miyashita, Misako Matsumoto, Tsukasa Seya
Published 2013-01-01

Role of Toll-like Receptors in Adjuvant-Augmented Immune Therapies

by Tsukasa Seya, Takashi Akazawa, Tadayuki Tsujita, Misako Matsumoto
Published 2006-01-01

The dataset of proteins specifically interacted with activated TICAM-1

by Kenji Funami, Misako Matsumoto, Hiroyuki Oshiumi, Chikashi Obuse, Tsukasa Seya
Published 2016-09-01

RIOK3-Mediated Phosphorylation of MDA5 Interferes with Its Assembly and Attenuates the Innate Immune Response

by Ken Takashima, Hiroyuki Oshiumi, Hiromi Takaki, Misako Matsumoto, Tsukasa Seya
Published 2015-04-01

Nucleic Acid Sensors Involved in the Recognition of HBV in the Liver–Specific in vivo Transfection Mouse Models—Pattern Recognition Receptors and Sensors for HBV

by Chean Ring Leong, Hiroyuki Oshiumi, Takayuki Suzuki, Misako Matsumoto, Tsukasa Seya
Published 2015-04-01

Toll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells

by Hiroaki Shime, Akira Maruyama, Sumito Yoshida, Yohei Takeda, Misako Matsumoto, Tsukasa Seya
Published 2018-01-01

Dendritic cells from oral cavity induce Foxp3(+) regulatory T cells upon antigen stimulation.

by Sayuri Yamazaki, Akira Maruyama, Kohei Okada, Misako Matsumoto, Akimichi Morita, Tsukasa Seya
Published 2012-01-01

TLR2-dependent induction of IL-10 and Foxp3+ CD25+ CD4+ regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo.

by Sayuri Yamazaki, Kohei Okada, Akira Maruyama, Misako Matsumoto, Hideo Yagita, Tsukasa Seya
Published 2011-01-01

A TLR3-Specific Adjuvant Relieves Innate Resistance to PD-L1 Blockade without Cytokine Toxicity in Tumor Vaccine Immunotherapy

by Yohei Takeda, Keisuke Kataoka, Junya Yamagishi, Seishi Ogawa, Tsukasa Seya, Misako Matsumoto
Published 2017-05-01

Type I Interferon-Independent Dendritic Cell Priming and Antitumor T Cell Activation Induced by a Mycoplasma fermentans Lipopeptide

by Yohei Takeda, Masahiro Azuma, Kenji Funami, Hiroaki Shime, Misako Matsumoto, Tsukasa Seya
Published 2018-03-01

Cell type-specific subcellular localization of phospho-TBK1 in response to cytoplasmic viral DNA.

by Takayuki Suzuki, Hiroyuki Oshiumi, Moeko Miyashita, Hussein Hassan Aly, Misako Matsumoto, Tsukasa Seya
Published 2013-01-01

Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response

by Takahisa Kouwaki, Masaaki Okamoto, Hirotake Tsukamoto, Yoshimi Fukushima, Misako Matsumoto, Tsukasa Seya, Hiroyuki Oshiumi
Published 2017-09-01

DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation

by Hiroyuki Oshiumi, Moeko Miyashita, Masaaki Okamoto, Yuka Morioka, Masaru Okabe, Misako Matsumoto, Tsukasa Seya
Published 2015-05-01

The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages.

by Sumito Yoshida, Hiroaki Shime, Kenji Funami, Hiromi Takaki, Misako Matsumoto, Masanori Kasahara, Tsukasa Seya
Published 2017-01-01

UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling.

by Hiroki Itoh, Megumi Tatematsu, Ayako Watanabe, Katsunori Iwano, Kenji Funami, Tsukasa Seya, Misako Matsumoto
Published 2011-01-01

Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV)

by Masato Nakai, Hiroyuki Oshiumi, Kenji Funami, Masaaki Okamoto, Misako Matsumoto, Tsukasa Seya, Naoya Sakamoto
Published 2015-10-01

Development of mouse hepatocyte lines permissive for hepatitis C virus (HCV).

by Hussein Hassan Aly, Hiroyuki Oshiumi, Hiroaki Shime, Misako Matsumoto, Taka Wakita, Kunitada Shimotohno, Tsukasa Seya
Published 2011-01-01

Anti-oxidative Amino Acid L-ergothioneine Modulates the Tumor Microenvironment to Facilitate Adjuvant Vaccine Immunotherapy

by Sumito Yoshida, Sumito Yoshida, Hiroaki Shime, Hiroaki Shime, Misako Matsumoto, Masanori Kasahara, Tsukasa Seya, Tsukasa Seya
Published 2019-04-01