Nedd8 hydrolysis by UCH proteases in Plasmodium parasites.

by Maryia Karpiyevich, Sophie Adjalley, Marco Mol, David B Ascher, Bethany Mason, Gerbrand J van der Heden van Noort, Heike Laman, Huib Ovaa, Marcus C S Lee, Katerina Artavanis-Tsakonas
Published 2019-10-01

Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine

by Duangkamon Loesbanluechai, Namfon Kotanan, Cristina de Cozar, Theerarat Kochakarn, Megan R. Ansbro, Kesinee Chotivanich, Nicholas J. White, Prapon Wilairat, Marcus C.S. Lee, Francisco Javier Gamo, Laura Maria Sanz, Thanat Chookajorn, Krittikorn Kümpornsin
Published 2019-04-01

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.

by Nina F Gnädig, Barbara H Stokes, Rachel L Edwards, Gavreel F Kalantarov, Kim C Heimsch, Michal Kuderjavy, Audrey Crane, Marcus C S Lee, Judith Straimer, Katja Becker, Ilya N Trakht, Audrey R Odom John, Sachel Mok, David A Fidock
Published 2020-04-01

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

by Ebere Sonoiki, Caroline L. Ng, Marcus C. S. Lee, Denghui Guo, Yong-Kang Zhang, Yasheen Zhou, M. R. K. Alley, Vida Ahyong, Laura M. Sanz, Maria Jose Lafuente-Monasterio, Chen Dong, Patrick G. Schupp, Jiri Gut, Jenny Legac, Roland A. Cooper, Francisco-Javier Gamo, Joseph DeRisi, Yvonne R. Freund, David A. Fidock, Philip J. Rosenthal
Published 2017-03-01

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

by Gregory M. LaMonte, Frances Rocamora, Danushka S. Marapana, Nina F. Gnädig, Sabine Ottilie, Madeline R. Luth, Tilla S. Worgall, Gregory M. Goldgof, Roxanne Mohunlal, T. R. Santha Kumar, Jennifer K. Thompson, Edgar Vigil, Jennifer Yang, Dylan Hutson, Trevor Johnson, Jianbo Huang, Roy M. Williams, Bing Yu Zou, Andrea L. Cheung, Prianka Kumar, Timothy J. Egan, Marcus C. S. Lee, Dionicio Siegel, Alan F. Cowman, David A. Fidock, Elizabeth A. Winzeler
Published 2020-04-01

A broad analysis of resistance development in the malaria parasite

by Victoria C. Corey, Amanda K. Lukens, Eva S. Istvan, Marcus C. S. Lee, Virginia Franco, Pamela Magistrado, Olivia Coburn-Flynn, Tomoyo Sakata-Kato, Olivia Fuchs, Nina F. Gnädig, Greg Goldgof, Maria Linares, Maria G. Gomez-Lorenzo, Cristina De Cózar, Maria Jose Lafuente-Monasterio, Sara Prats, Stephan Meister, Olga Tanaseichuk, Melanie Wree, Yingyao Zhou, Paul A. Willis, Francisco-Javier Gamo, Daniel E. Goldberg, David A. Fidock, Dyann F. Wirth, Elizabeth A. Winzeler
Published 2016-06-01