Evidence that the Plasmodium falciparum Protein Sortilin Potentially Acts as an Escorter for the Trafficking of the Rhoptry-Associated Membrane Antigen to the Rhoptries

by Stéphanie Halléée, Justin A. Boddey, Alan F. Cowman, Dave Richard, Photini Sinnis
Published 2018-01-01

Invasion by P. falciparum merozoites suggests a hierarchy of molecular interactions.

by Jake Baum, Alexander G Maier, Robert T Good, Ken M Simpson, Alan F Cowman
Published 2005-12-01

Investigation of the Plasmodium falciparum food vacuole through inducible expression of the chloroquine resistance transporter (PfCRT).

by Florian Ehlgen, James S Pham, Tania de Koning-Ward, Alan F Cowman, Stuart A Ralph
Published 2012-01-01

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

by Lin Chen, Yibin Xu, Julie Healer, Jenny K Thompson, Brian J Smith, Michael C Lawrence, Alan F Cowman
Published 2014-10-01

Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite.

by Kerstin Leykauf, Moritz Treeck, Paul R Gilson, Thomas Nebl, Thomas Braulke, Alan F Cowman, Tim W Gilberger, Brendan S Crabb
Published 2010-06-01

Efficient measurement of opsonising antibodies to Plasmodium falciparum merozoites.

by Danika L Hill, Emily M Eriksson, Amandine B Carmagnac, Danny W Wilson, Alan F Cowman, Diana S Hansen, Louis Schofield
Published 2012-01-01

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA

by Lin Chen, Yibin Xu, Wilson Wong, Jennifer K Thompson, Julie Healer, Ethan D Goddard-Borger, Michael C Lawrence, Alan F Cowman
Published 2017-02-01

Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRh2a and b binding domains.

by Tony Triglia, Lin Chen, Sash Lopaticki, Chaitali Dekiwadia, David T Riglar, Anthony N Hodder, Stuart A Ralph, Jake Baum, Alan F Cowman
Published 2011-06-01

Identification of rhoptry trafficking determinants and evidence for a novel sorting mechanism in the malaria parasite Plasmodium falciparum.

by Dave Richard, Lev M Kats, Christine Langer, Casilda G Black, Khosse Mitri, Justin A Boddey, Alan F Cowman, Ross L Coppel
Published 2009-03-01

Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex.

by Thomas Nebl, Judith Helena Prieto, Eugene Kapp, Brian J Smith, Melanie J Williams, John R Yates, Alan F Cowman, Christopher J Tonkin
Published 2011-09-01

Development and application of a high-throughput screening assay for identification of small molecule inhibitors of the P. falciparum reticulocyte binding-like homologue 5 protein

by Brad E. Sleebs, Kate E. Jarman, Sonja Frolich, Wilson Wong, Julie Healer, Weiwen Dai, Isabelle S. Lucet, Danny W. Wilson, Alan F. Cowman
Published 2020-12-01

Defining the antigenic diversity of Plasmodium falciparum apical membrane antigen 1 and the requirements for a multi-allele vaccine against malaria.

by Damien R Drew, Anthony N Hodder, Danny W Wilson, Michael Foley, Ivo Mueller, Peter M Siba, Arlene E Dent, Alan F Cowman, James G Beeson
Published 2012-01-01

Expression of P. falciparum var genes involves exchange of the histone variant H2A.Z at the promoter.

by Michaela Petter, Chin Chin Lee, Timothy J Byrne, Katja E Boysen, Jennifer Volz, Stuart A Ralph, Alan F Cowman, Graham V Brown, Michael F Duffy
Published 2011-02-01

Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Transmission to Mosquitoes

by Charlie Jennison, Leonardo Lucantoni, Matthew T. O’Neill, Robyn McConville, Sara M. Erickson, Alan F. Cowman, Brad E. Sleebs, Vicky M. Avery, Justin A. Boddey
Published 2019-12-01

Protein Kinase A Is Essential for Invasion of Plasmodium falciparum into Human Erythrocytes

by Mary-Louise Wilde, Tony Triglia, Danushka Marapana, Jennifer K. Thompson, Alexei A. Kouzmitchev, Hayley E. Bullen, Paul R. Gilson, Alan F. Cowman, Christopher J. Tonkin
Published 2019-10-01

Association of antibodies to Plasmodium falciparum Reticulocyte Binding Protein Homologue 5 with protection from clinical malaria

by Chris Y. H. Chiu, Chris Y. H. Chiu, Julie eHealer, Jennifer K. Thompson, Lin eChen, Aiki eKaul, Laxman eSavergave, Arjun eRaghuwanshi, Connie S. N, Li Wai Suen, Peter M. Siba, Louis eSchofield, Louis eSchofield, Ivo eMueller, Ivo eMueller, Alan F Cowman, Alan F Cowman, Diana Silvia Hansen, Diana Silvia Hansen
Published 2014-06-01

An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum.

by Lin Chen, Sash Lopaticki, David T Riglar, Chaitali Dekiwadia, Alex D Uboldi, Wai-Hong Tham, Matthew T O'Neill, Dave Richard, Jake Baum, Stuart A Ralph, Alan F Cowman
Published 2011-09-01

Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria.

by Patience B Tetteh-Quarcoo, Christoph Q Schmidt, Wai-Hong Tham, Richard Hauhart, Haydyn D T Mertens, Arthur Rowe, John P Atkinson, Alan F Cowman, J Alexandra Rowe, Paul N Barlow
Published 2012-01-01

Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors.

by Christian Flueck, Richard Bartfai, Jennifer Volz, Igor Niederwieser, Adriana M Salcedo-Amaya, Blaise T F Alako, Florian Ehlgen, Stuart A Ralph, Alan F Cowman, Zbynek Bozdech, Hendrik G Stunnenberg, Till S Voss
Published 2009-09-01

A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial

by Rebecca Pawliw, Rebecca Farrow, Silvana Sekuloski, Helen Jennings, Julie Healer, Thuan Phuong, Pri Sathe, Cielo Pasay, Krystal Evans, Alan F. Cowman, Louis Schofield, Nanhua Chen, James McCarthy, Katharine Trenholme
Published 2018-08-01