A Novel Triple-Fluorescent HCMV Strain Reveals Gene Expression Dynamics and Anti-Herpesviral Drug Mechanisms

by Ulfert Rand, Tobias Kubsch, Bahram Kasmapour, Bahram Kasmapour, Luka Cicin-Sain, Luka Cicin-Sain, Luka Cicin-Sain, Luka Cicin-Sain
Published 2021-01-01

Vaccine Vectors Harnessing the Power of Cytomegaloviruses

by Mario Alberto Ynga-Durand, Iryna Dekhtiarenko, Luka Cicin-Sain
Published 2019-10-01

UL36 Rescues Apoptosis Inhibition and In vivo Replication of a Chimeric MCMV Lacking the M36 Gene

by M. Zeeshan Chaudhry, M. Zeeshan Chaudhry, Bahram Kasmapour, Carlos Plaza-Sirvent, Carlos Plaza-Sirvent, Milica Bajagic, Rosaely Casalegno Garduño, Lisa Borkner, Tihana Lenac Roviš, Andrea Scrima, Stipan Jonjic, Stipan Jonjic, Ingo Schmitz, Ingo Schmitz, Luka Cicin-Sain, Luka Cicin-Sain, Luka Cicin-Sain
Published 2017-07-01

Life-long control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemia.

by Nico A Contreras, Katarzyna M Sitnik, Ilija Jeftic, Christopher Patrick Coplen, Luka Čičin-Šain, Janko Nikolich-Žugich
Published 2019-06-01

Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging.

by Luka Cicin-Sain, James D Brien, Jennifer L Uhrlaub, Anja Drabig, Thomas F Marandu, Janko Nikolich-Zugich
Published 2012-01-01

Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts.

by Linda Ebermann, Zsolt Ruzsics, Carlos A Guzmán, Nico van Rooijen, Rosaely Casalegno-Garduño, Ulrich Koszinowski, Luka Čičin-Šain
Published 2012-01-01

A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus.

by Yoshimi Tsuda, Patrizia Caposio, Christopher J Parkins, Sara Botto, Ilhem Messaoudi, Luka Cicin-Sain, Heinz Feldmann, Michael A Jarvis
Published 2011-08-01

Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate Immunity

by Ulfert Rand, Sascha Young Kupke, Hanna Shkarlet, Marc Dominique Hein, Tatjana Hirsch, Pavel Marichal-Gallardo, Luka Cicin-Sain, Udo Reichl, Dunja Bruder
Published 2021-07-01

Early primed KLRG1- CMV-specific T cells determine the size of the inflationary T cell pool.

by Nicolas S Baumann, Suzanne P M Welten, Nicole Torti, Katharina Pallmer, Mariana Borsa, Isabel Barnstorf, Jennifer D Oduro, Luka Cicin-Sain, Annette Oxenius
Published 2019-05-01

The viral context instructs the redundancy of costimulatory pathways in driving CD8+ T cell expansion

by Suzanne PM Welten, Anke Redeker, Kees LMC Franken, Jennifer D Oduro, Ferry Ossendorp, Luka Čičin-Šain, Cornelis JM Melief, Peter Aichele, Ramon Arens
Published 2015-08-01

Human monocyte-derived macrophages inhibit HCMV spread independent of classical antiviral cytokines

by Jennifer Becker, Volker Kinast, Marius Döring, Christoph Lipps, Veronica Duran, Julia Spanier, Pia-Katharina Tegtmeyer, Dagmar Wirth, Luka Cicin-Sain, Antonio Alcamí, Ulrich Kalinke
Published 2018-12-01

Demarcated thresholds of tumor-specific CD8 T cells elicited by MCMV-based vaccine vectors provide robust correlates of protection

by Elham Beyranvand Nejad, Robert B. Ratts, Eleni Panagioti, Christine Meyer, Jennifer D. Oduro, Luka Cicin-Sain, Klaus Früh, Sjoerd H. van der Burg, Ramon Arens
Published 2019-01-01

IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.

by Branka Popovic, Mijo Golemac, Jürgen Podlech, Jelena Zeleznjak, Lidija Bilic-Zulle, Miodrag L Lukic, Luka Cicin-Sain, Matthias J Reddehase, Tim Sparwasser, Astrid Krmpotic, Stipan Jonjic
Published 2017-04-01

Tissue maintenance of CMV-specific inflationary memory T cells by IL-15.

by Nicolas S Baumann, Nicole Torti, Suzanne P M Welten, Isabel Barnstorf, Mariana Borsa, Katharina Pallmer, Jennifer D Oduro, Luka Cicin-Sain, Koichi Ikuta, Burkhard Ludewig, Annette Oxenius
Published 2018-04-01

Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20

by Yoav Charpak-Amikam, Tobias Kubsch, Einat Seidel, Esther Oiknine-Djian, Noemi Cavaletto, Rachel Yamin, Dominik Schmiedel, Dana Wolf, Giorgio Gribaudo, Martin Messerle, Luka Cicin-Sain, Ofer Mandelboim
Published 2017-08-01

Tcf1+ cells are required to maintain the inflationary T cell pool upon MCMV infection

by Suzanne P. M. Welten, Alexander Yermanos, Nicolas S. Baumann, Franziska Wagen, Nathalie Oetiker, Ioana Sandu, Alessandro Pedrioli, Jennifer D. Oduro, Sai T. Reddy, Luka Cicin-Sain, Werner Held, Annette Oxenius
Published 2020-05-01

Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge.

by Xiaoyan Zheng, Jennifer D Oduro, Julia D Boehme, Lisa Borkner, Thomas Ebensen, Ulrike Heise, Marcus Gereke, Marina C Pils, Astrid Krmpotic, Carlos A Guzmán, Dunja Bruder, Luka Čičin-Šain
Published 2019-09-01

The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages.

by Nadine Thiel, Kirsten A Keyser, Niels A W Lemmermann, Jennifer D Oduro, Karen Wagner, Carina Elsner, Anne Halenius, Tihana Lenac Roviš, Melanie M Brinkmann, Stipan Jonjić, Luka Cicin-Sain, Martin Messerle
Published 2016-12-01

Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling

by Franz Puttur, Marcela Francozo, Gülhas Solmaz, Carlos Bueno, Marc Lindenberg, Melanie Gohmert, Maxine Swallow, Dejene Tufa, Roland Jacobs, Stefan Lienenklaus, Anja A. Kühl, Lisa Borkner, Luka Cicin-Sain, Bernard Holzmann, Hermann Wagner, Luciana Berod, Tim Sparwasser
Published 2016-10-01

Reversible silencing of cytomegalovirus genomes by type I interferon governs virus latency.

by Franziska Dağ, Lars Dölken, Julia Holzki, Anja Drabig, Adrien Weingärtner, Johannes Schwerk, Stefan Lienenklaus, Ianina Conte, Robert Geffers, Colin Davenport, Ulfert Rand, Mario Köster, Siegfried Weiß, Barbara Adler, Dagmar Wirth, Martin Messerle, Hansjörg Hauser, Luka Cičin-Šain
Published 2014-02-01