Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases

by Jennifer L. Asimit, Daniel B. Rainbow, Mary D. Fortune, Nastasiya F. Grinberg, Linda S. Wicker, Chris Wallace
Published 2019-07-01

In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment

by Ricardo C. Ferreira, Daniel B. Rainbow, Arcadio Rubio García, Marcin L. Pekalski, Linsey Porter, João J. Oliveira, Frank Waldron-Lynch, Linda S. Wicker, John A. Todd
Published 2017-06-01

Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes.

by Nora M Kochupurakkal, Annie J Kruger, Sudipta Tripathi, Bing Zhu, La Tonya Adams, Daniel B Rainbow, Aldo Rossini, Dale L Greiner, Mohamed H Sayegh, Linda S Wicker, Indira Guleria
Published 2014-01-01

Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice.

by Jochen Mattner, Javid P Mohammed, Michael E Fusakio, Claudia Giessler, Carl-Philipp Hackstein, Robert Opoka, Marius Wrage, Regina Schey, Jan Clark, Heather I Fraser, Daniel B Rainbow, Linda S Wicker
Published 2019-06-01

Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

by Dominik Trzupek, Melanie Dunstan, Antony J. Cutler, Mercede Lee, Leila Godfrey, Lorna Jarvis, Daniel B. Rainbow, Dominik Aschenbrenner, Joanne L. Jones, Holm H. Uhlig, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira
Published 2020-06-01

The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus

by João J. Oliveira, Sarah Karrar, Daniel B. Rainbow, Christopher L. Pinder, Pamela Clarke, Arcadio Rubio García, Osama Al-Assar, Keith Burling, Sian Morris, Richard Stratton, Tim J. Vyse, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira
Published 2018-07-01

Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial [version 2; referees: 2 approved]

by Antony J. Cutler, Joao Oliveira, Ricardo C. Ferreira, Ben Challis, Neil M. Walker, Sarah Caddy, Jia Lu, Helen E. Stevens, Deborah J. Smyth, Marcin L. Pekalski, Jane Kennet, Kara M.D. Hunter, Ian Goodfellow, Linda S. Wicker, John A. Todd, Frank Waldron-Lynch
Published 2017-07-01

Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial [version 3; referees: 2 approved]

by Antony J. Cutler, Joao Oliveira, Ricardo C. Ferreira, Ben Challis, Neil M. Walker, Sarah Caddy, Jia Lu, Helen E. Stevens, Deborah J. Smyth, Marcin L. Pekalski, Jane Kennet, Kara M.D. Hunter, Ian Goodfellow, Linda S. Wicker, John A. Todd, Frank Waldron-Lynch
Published 2017-10-01

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping.

by Chris Wallace, Antony J Cutler, Nikolas Pontikos, Marcin L Pekalski, Oliver S Burren, Jason D Cooper, Arcadio Rubio García, Ricardo C Ferreira, Hui Guo, Neil M Walker, Deborah J Smyth, Stephen S Rich, Suna Onengut-Gumuscu, Stephen J Sawcer, Maria Ban, Sylvia Richardson, John A Todd, Linda S Wicker
Published 2015-06-01

Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression

by Ricardo C. Ferreira, Xaquin Castro Dopico, João J. Oliveira, Daniel B. Rainbow, Jennie H. Yang, Dominik Trzupek, Sarah A. Todd, Mhairi McNeill, Maristella Steri, Valeria Orrù, Edoardo Fiorillo, Daniel J. M. Crouch, Marcin L. Pekalski, Francesco Cucca, Francesco Cucca, Tim I. Tree, Tim J. Vyse, Linda S. Wicker, John A. Todd
Published 2019-11-01

IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.

by Lisa M Maier, Christopher E Lowe, Jason Cooper, Kate Downes, David E Anderson, Christopher Severson, Pamela M Clark, Brian Healy, Neil Walker, Cristin Aubin, Jorge R Oksenberg, Stephen L Hauser, Alistair Compston, Stephen Sawcer, International Multiple Sclerosis Genetics Consortium, Philip L De Jager, Linda S Wicker, John A Todd, David A Hafler
Published 2009-01-01

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

by Oliver S. Burren, Arcadio Rubio García, Biola-Maria Javierre, Daniel B. Rainbow, Jonathan Cairns, Nicholas J. Cooper, John J. Lambourne, Ellen Schofield, Xaquin Castro Dopico, Ricardo C. Ferreira, Richard Coulson, Frances Burden, Sophia P. Rowlston, Kate Downes, Steven W. Wingett, Mattia Frontini, Willem H. Ouwehand, Peter Fraser, Mikhail Spivakov, John A. Todd, Linda S. Wicker, Antony J. Cutler, Chris Wallace
Published 2017-09-01

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial.

by John A Todd, Marina Evangelou, Antony J Cutler, Marcin L Pekalski, Neil M Walker, Helen E Stevens, Linsey Porter, Deborah J Smyth, Daniel B Rainbow, Ricardo C Ferreira, Laura Esposito, Kara M D Hunter, Kevin Loudon, Kathryn Irons, Jennie H Yang, Charles J M Bell, Helen Schuilenburg, James Heywood, Ben Challis, Sankalpa Neupane, Pamela Clarke, Gillian Coleman, Sarah Dawson, Donna Goymer, Katerina Anselmiova, Jane Kennet, Judy Brown, Sarah L Caddy, Jia Lu, Jane Greatorex, Ian Goodfellow, Chris Wallace, Tim I Tree, Mark Evans, Adrian P Mander, Simon Bond, Linda S Wicker, Frank Waldron-Lynch
Published 2016-10-01