The MS Remyelinating Drug Bexarotene (an RXR Agonist) Promotes Induction of Human Tregs and Suppresses Th17 Differentiation In Vitro

by Christopher M. Gaunt, Daniel B. Rainbow, Daniel B. Rainbow, Ruairi J. Mackenzie, Lorna B. Jarvis, Hani S. Mousa, Nicholas Cunniffe, Zoya Georgieva, J. William Brown, Alasdair J. Coles, Joanne L. Jones
Published 2021-08-01

Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases

by Jennifer L. Asimit, Daniel B. Rainbow, Mary D. Fortune, Nastasiya F. Grinberg, Linda S. Wicker, Chris Wallace
Published 2019-07-01

In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment

by Ricardo C. Ferreira, Daniel B. Rainbow, Arcadio Rubio García, Marcin L. Pekalski, Linsey Porter, João J. Oliveira, Frank Waldron-Lynch, Linda S. Wicker, John A. Todd
Published 2017-06-01

Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes.

by Nora M Kochupurakkal, Annie J Kruger, Sudipta Tripathi, Bing Zhu, La Tonya Adams, Daniel B Rainbow, Aldo Rossini, Dale L Greiner, Mohamed H Sayegh, Linda S Wicker, Indira Guleria
Published 2014-01-01

Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice.

by Jochen Mattner, Javid P Mohammed, Michael E Fusakio, Claudia Giessler, Carl-Philipp Hackstein, Robert Opoka, Marius Wrage, Regina Schey, Jan Clark, Heather I Fraser, Daniel B Rainbow, Linda S Wicker
Published 2019-06-01

Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

by Dominik Trzupek, Melanie Dunstan, Antony J. Cutler, Mercede Lee, Leila Godfrey, Lorna Jarvis, Daniel B. Rainbow, Dominik Aschenbrenner, Joanne L. Jones, Holm H. Uhlig, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira
Published 2020-06-01

The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus

by João J. Oliveira, Sarah Karrar, Daniel B. Rainbow, Christopher L. Pinder, Pamela Clarke, Arcadio Rubio García, Osama Al-Assar, Keith Burling, Sian Morris, Richard Stratton, Tim J. Vyse, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira
Published 2018-07-01

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases.

by Ricardo C Ferreira, Daniel F Freitag, Antony J Cutler, Joanna M M Howson, Daniel B Rainbow, Deborah J Smyth, Stephen Kaptoge, Pamela Clarke, Charlotte Boreham, Richard M Coulson, Marcin L Pekalski, Wei-Min Chen, Suna Onengut-Gumuscu, Stephen S Rich, Adam S Butterworth, Anders Malarstig, John Danesh, John A Todd
Published 2013-04-01

Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression

by Ricardo C. Ferreira, Xaquin Castro Dopico, João J. Oliveira, Daniel B. Rainbow, Jennie H. Yang, Dominik Trzupek, Sarah A. Todd, Mhairi McNeill, Maristella Steri, Valeria Orrù, Edoardo Fiorillo, Daniel J. M. Crouch, Marcin L. Pekalski, Francesco Cucca, Francesco Cucca, Tim I. Tree, Tim J. Vyse, Linda S. Wicker, John A. Todd
Published 2019-11-01

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

by Oliver S. Burren, Arcadio Rubio García, Biola-Maria Javierre, Daniel B. Rainbow, Jonathan Cairns, Nicholas J. Cooper, John J. Lambourne, Ellen Schofield, Xaquin Castro Dopico, Ricardo C. Ferreira, Richard Coulson, Frances Burden, Sophia P. Rowlston, Kate Downes, Steven W. Wingett, Mattia Frontini, Willem H. Ouwehand, Peter Fraser, Mikhail Spivakov, John A. Todd, Linda S. Wicker, Antony J. Cutler, Chris Wallace
Published 2017-09-01

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial.

by John A Todd, Marina Evangelou, Antony J Cutler, Marcin L Pekalski, Neil M Walker, Helen E Stevens, Linsey Porter, Deborah J Smyth, Daniel B Rainbow, Ricardo C Ferreira, Laura Esposito, Kara M D Hunter, Kevin Loudon, Kathryn Irons, Jennie H Yang, Charles J M Bell, Helen Schuilenburg, James Heywood, Ben Challis, Sankalpa Neupane, Pamela Clarke, Gillian Coleman, Sarah Dawson, Donna Goymer, Katerina Anselmiova, Jane Kennet, Judy Brown, Sarah L Caddy, Jia Lu, Jane Greatorex, Ian Goodfellow, Chris Wallace, Tim I Tree, Mark Evans, Adrian P Mander, Simon Bond, Linda S Wicker, Frank Waldron-Lynch
Published 2016-10-01