The Role of Microglia in Prion Diseases: A Paradigm of Functional Diversity

by Juliane Obst, Emilie Simon, Renzo Mancuso, Diego Gomez-Nicola
Published 2017-06-01

PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages

by Juliane Obst, Hazel L. Hall-Roberts, Thomas B. Smith, Mira Kreuzer, Lorenza Magno, Elena Di Daniel, John B. Davis, Emma Mead
Published 2021-10-01

TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages

by Hazel Hall-Roberts, Devika Agarwal, Juliane Obst, Thomas B. Smith, Jimena Monzón-Sandoval, Elena Di Daniel, Caleb Webber, William S. James, Emma Mead, John B. Davis, Sally A. Cowley
Published 2020-11-01

Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration

by Juliane Obst, Emilie Simon, Maria Martin-Estebane, Elena Pipi, Liana M. Barkwill, Ivette Gonzalez-Rivera, Fergus Buchanan, Alan R. Prescott, Dorte Faust, Simon Fox, Janet Brownlees, Debra Taylor, V. Hugh Perry, Hugh Nuthall, Peter J. Atkinson, Eric Karran, Carol Routledge, Diego Gomez-Nicola
Published 2020-10-01