The Role of Microglia in Synaptic Stripping and Synaptic Degeneration: A Revised Perspective

by V Hugh Perry, Vincent O'Connor
Published 2010-09-01

Early Hippocampal Synaptic Loss Precedes Neuronal Loss and Associates with Early Behavioural Deficits in Three Distinct Strains of Prion Disease.

by Kathryn J Hilton, Colm Cunningham, Richard A Reynolds, V Hugh Perry
Published 2013-01-01

Brain region specific pre-synaptic and post-synaptic degeneration are early components of neuropathology in prion disease.

by Zuzana Šišková, Richard A Reynolds, Vincent O'Connor, V Hugh Perry
Published 2013-01-01

Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration

by Karine Palin, Colm Cunningham, Penny Forse, V. Hugh Perry, Nick Platt
Published 2008-04-01

Selective presynaptic degeneration in the synaptopathy associated with ME7-induced hippocampal pathology

by Bryony C. Gray, Zuzana Siskova, V. Hugh Perry, Vincent O'Connor
Published 2009-07-01

TGFβ1 regulates the inflammatory response during chronic neurodegeneration

by Delphine Boche, Colm Cunningham, Fabian Docagne, Helen Scott, V. Hugh Perry
Published 2006-06-01

Soluble axoplasm enriched from injured CNS axons reveals the early modulation of the actin cytoskeleton.

by Patrick Garland, Lucy J Broom, Shmma Quraishe, Paul D Dalton, Paul Skipp, Tracey A Newman, V Hugh Perry
Published 2012-01-01

The role of activity in synaptic degeneration in a protein misfolding disease, prion disease.

by Matteo Caleo, Laura Restani, Eleonora Vannini, Zuzana Siskova, Hussain Al-Malki, Ruth Morgan, Vincent O'Connor, V Hugh Perry
Published 2012-01-01

Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration.

by James Alibhai, Richard A Blanco, Marcelo A Barria, Pedro Piccardo, Byron Caughey, V Hugh Perry, Tom C Freeman, Jean C Manson
Published 2016-11-01

Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer’s disease

by Sarmi Sri, Chrysia-Maria Pegasiou, Chantal Abbigail Cave, Katie Hough, Natalie Wood, Diego Gomez-Nicola, Katrin Deinhardt, David Bannerman, V. Hugh Perry, Mariana Vargas-Caballero
Published 2019-02-01

MRI and MRS alterations in the preclinical phase of murine prion disease: Association with neuropathological and behavioural changes

by Kerry A. Broom, Daniel C. Anthony, John P. Lowe, Julian L. Griffin, Helen Scott, Andrew M. Blamire, Peter Styles, V. Hugh Perry, Nicola R. Sibson
Published 2007-06-01

An Inducible Mouse Model of Late Onset Tay–Sachs Disease

by Mylvaganam Jeyakumar, David Smith, Elena Eliott-Smith, Mario Cortina-Borja, Gabriele Reinkensmeier, Terry D. Butters, Thorsten Lemm, Konrad Sandhoff, V.Hugh Perry, Raymond A. Dwek, Frances M. Platt
Published 2002-08-01

Periodontitis and Cognitive Decline in Alzheimer's Disease.

by Mark Ide, Marina Harris, Annette Stevens, Rebecca Sussams, Viv Hopkins, David Culliford, James Fuller, Paul Ibbett, Rachel Raybould, Rhodri Thomas, Ursula Puenter, Jessica Teeling, V Hugh Perry, Clive Holmes
Published 2016-01-01

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

by Katharine Askew, Kaizhen Li, Adrian Olmos-Alonso, Fernando Garcia-Moreno, Yajie Liang, Philippa Richardson, Tom Tipton, Mark A. Chapman, Kristoffer Riecken, Sol Beccari, Amanda Sierra, Zoltán Molnár, Mark S. Cragg, Olga Garaschuk, V. Hugh Perry, Diego Gomez-Nicola
Published 2017-01-01

Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration

by Juliane Obst, Emilie Simon, Maria Martin-Estebane, Elena Pipi, Liana M. Barkwill, Ivette Gonzalez-Rivera, Fergus Buchanan, Alan R. Prescott, Dorte Faust, Simon Fox, Janet Brownlees, Debra Taylor, V. Hugh Perry, Hugh Nuthall, Peter J. Atkinson, Eric Karran, Carol Routledge, Diego Gomez-Nicola
Published 2020-10-01