Honing the Double-Edged Sword: Improving Human iPSC-Microglia Models

by Anne Hedegaard, Szymon Stodolak, William S. James, Sally A. Cowley
Published 2020-12-01

Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions.

by Bonnie van Wilgenburg, Cathy Browne, Jane Vowles, Sally A Cowley
Published 2013-01-01

The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4.

by Bonnie van Wilgenburg, Michael D Moore, William S James, Sally A Cowley
Published 2014-01-01

Rates of homology directed repair of CRISPR-Cas9 induced double strand breaks are lower in naïve compared to primed human pluripotent stem cells

by Benjamin T. Dodsworth, Klas Hatje, Claas Aiko Meyer, Rowan Flynn, Sally A. Cowley
Published 2020-07-01

Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration.

by Lihong Zhou, Elena Sokolskaja, Clare Jolly, William James, Sally A Cowley, Ariberto Fassati
Published 2011-08-01

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex

by Ulrike Künzel, Adam Graham Grieve, Yao Meng, Boris Sieber, Sally A Cowley, Matthew Freeman
Published 2018-06-01

Genome-wide CRISPR/Cas9-knockout in human induced Pluripotent Stem Cell (iPSC)-derived macrophages

by Elena Navarro-Guerrero, Chwen Tay, Justin P. Whalley, Sally A. Cowley, Ben Davies, Julian C. Knight, Daniel Ebner
Published 2021-02-01

Physiological characterisation of human iPS-derived dopaminergic neurons.

by Elizabeth M Hartfield, Michiko Yamasaki-Mann, Hugo J Ribeiro Fernandes, Jane Vowles, William S James, Sally A Cowley, Richard Wade-Martins
Published 2014-01-01

MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons

by Joel E. Beevers, Mang Ching Lai, Emma Collins, Heather D.E. Booth, Federico Zambon, Laura Parkkinen, Jane Vowles, Sally A. Cowley, Richard Wade-Martins, Tara M. Caffrey
Published 2017-08-01

TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages

by Hazel Hall-Roberts, Devika Agarwal, Juliane Obst, Thomas B. Smith, Jimena Monzón-Sandoval, Elena Di Daniel, Caleb Webber, William S. James, Emma Mead, John B. Davis, Sally A. Cowley
Published 2020-11-01

Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation

by Maggie M. K. Wong, Stephanie D. Hoekstra, Jane Vowles, Lauren M. Watson, Geraint Fuller, Andrea H. Németh, Sally A. Cowley, Olaf Ansorge, Kevin Talbot, Esther B. E. Becker
Published 2018-09-01

RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes

by Heather D.E. Booth, Frank Wessely, Natalie Connor-Robson, Federica Rinaldi, Jane Vowles, Cathy Browne, Samuel G. Evetts, Michele T. Hu, Sally A. Cowley, Caleb Webber, Richard Wade-Martins
Published 2019-09-01

Molecular and electrophysiological features of spinocerebellar ataxia type seven in induced pluripotent stem cells.

by Richard J Burman, Lauren M Watson, Danielle C Smith, Joseph V Raimondo, Robea Ballo, Janine Scholefield, Sally A Cowley, Matthew J A Wood, Susan H Kidson, Leslie J Greenberg
Published 2021-01-01

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages

by Walther Haenseler, Federico Zambon, Heyne Lee, Jane Vowles, Federica Rinaldi, Galbha Duggal, Henry Houlden, Katrina Gwinn, Selina Wray, Kelvin C. Luk, Richard Wade-Martins, William S. James, Sally A. Cowley
Published 2017-08-01

Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening

by Simon Gutbier, Florian Wanke, Nadine Dahm, Anna Rümmelin, Silke Zimmermann, Klaus Christensen, Fabian Köchl, Anna Rautanen, Klas Hatje, Barbara Geering, Jitao David Zhang, Markus Britschgi, Sally A. Cowley, Christoph Patsch
Published 2020-07-01

An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2

by Natalie Connor-Robson, Heather Booth, Jeffrey G. Martin, Benbo Gao, Kejie Li, Natalie Doig, Jane Vowles, Cathy Browne, Laura Klinger, Peter Juhasz, Christine Klein, Sally A. Cowley, Paul Bolam, Warren Hirst, Richard Wade-Martins
Published 2019-07-01

Alzheimer’s Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia

by Marvin Reich, Marvin Reich, Iñaki Paris, Iñaki Paris, Martin Ebeling, Nadine Dahm, Christophe Schweitzer, Dieter Reinhardt, Roland Schmucki, Megana Prasad, Fabian Köchl, Marcel Leist, Sally A. Cowley, Jitao David Zhang, Christoph Patsch, Simon Gutbier, Markus Britschgi
Published 2021-02-01

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response

by Walther Haenseler, Stephen N. Sansom, Julian Buchrieser, Sarah E. Newey, Craig S. Moore, Francesca J. Nicholls, Satyan Chintawar, Christian Schnell, Jack P. Antel, Nicholas D. Allen, M. Zameel Cader, Richard Wade-Martins, William S. James, Sally A. Cowley
Published 2017-06-01

Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons

by Christa Überbacher, Julia Obergasteiger, Mattia Volta, Serena Venezia, Stefan Müller, Isabella Pesce, Sara Pizzi, Giulia Lamonaca, Anne Picard, Giada Cattelan, Giorgio Malpeli, Michele Zoli, Dayne Beccano-Kelly, Rowan Flynn, Richard Wade-Martins, Peter P. Pramstaller, Andrew A. Hicks, Sally A. Cowley, Corrado Corti
Published 2019-12-01

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

by Hugo J.R. Fernandes, Elizabeth M. Hartfield, Helen C. Christian, Evangelia Emmanoulidou, Ying Zheng, Heather Booth, Helle Bogetofte, Charmaine Lang, Brent J. Ryan, S. Pablo Sardi, Jennifer Badger, Jane Vowles, Samuel Evetts, George K. Tofaris, Kostas Vekrellis, Kevin Talbot, Michele T. Hu, William James, Sally A. Cowley, Richard Wade-Martins
Published 2016-03-01