A common feature pharmacophore for FDA-approved drugs inhibiting the Ebola virus [v2; ref status: indexed, http://f1000r.es/4wt]

by Sean Ekins, Joel S. Freundlich, Megan Coffee
Published 2014-12-01

A common feature pharmacophore for FDA-approved drugs inhibiting the Ebola virus [v1; ref status: indexed, http://f1000r.es/4qh]

by Sean Ekins, Joel S. Freundlich, Megan Coffee
Published 2014-11-01

Machine learning models identify molecules active against the Ebola virus in vitro [version 2; referees: 2 approved]

by Sean Ekins, Joel S. Freundlich, Alex M. Clark, Manu Anantpadma, Robert A. Davey, Peter Madrid
Published 2016-01-01

Machine learning models identify molecules active against the Ebola virus in vitro [version 1; referees: 2 approved]

by Sean Ekins, Joel S. Freundlich, Alex M. Clark, Manu Anantpadma, Robert A. Davey, Peter Madrid
Published 2015-10-01

Machine learning models identify molecules active against the Ebola virus in vitro [version 3; referees: 2 approved]

by Sean Ekins, Joel S. Freundlich, Alex M. Clark, Manu Anantpadma, Robert A. Davey, Peter Madrid
Published 2017-01-01

Enhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian models.

by Sean Ekins, Robert C Reynolds, Scott G Franzblau, Baojie Wan, Joel S Freundlich, Barry A Bunin
Published 2013-01-01

Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection.

by Thomas R Lane, Christopher Massey, Jason E Comer, Manu Anantpadma, Joel S Freundlich, Robert A Davey, Peter B Madrid, Sean Ekins
Published 2019-11-01

A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis.

by Lauren Forbes, Katherine Ebsworth-Mojica, Louis DiDone, Shao-Gang Li, Joel S Freundlich, Nancy Connell, Paul M Dunman, Damian J Krysan
Published 2015-01-01

Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis.

by Satheesh K Palaninathan, Nilofar N Mohamedmohaideen, Elisabetta Orlandini, Gabriella Ortore, Susanna Nencetti, Annalina Lapucci, Armando Rossello, Joel S Freundlich, James C Sacchettini
Published 2009-07-01

Structural basis of DSF recognition by its receptor RpfR and its regulatory interaction with the DSF synthase RpfF.

by Evan J Waldron, Daniel Snyder, Nicolas L Fernandez, Emily Sileo, Daigo Inoyama, Joel S Freundlich, Christopher M Waters, Vaughn S Cooper, Matthew B Neiditch
Published 2019-02-01

Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads

by Manu Anantpadma, Thomas Lane, Kimberley M. Zorn, Mary A. Lingerfelt, Alex M. Clark, Joel S. Freundlich, Robert A. Davey, Peter B. Madrid, Sean Ekins
Published 2019-01-01

Open drug discovery for the Zika virus [version 1; referees: 3 approved]

by Sean Ekins, Daniel Mietchen, Megan Coffee, Thomas P Stratton, Joel S Freundlich, Lucio Freitas-Junior, Eugene Muratov, Jair Siqueira-Neto, Antony J Williams, Carolina Andrade
Published 2016-02-01

Combining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug Discovery.

by Sean Ekins, Peter B Madrid, Malabika Sarker, Shao-Gang Li, Nisha Mittal, Pradeep Kumar, Xin Wang, Thomas P Stratton, Matthew Zimmerman, Carolyn Talcott, Pauline Bourbon, Mike Travers, Maneesh Yadav, Joel S Freundlich
Published 2015-01-01

A brief review of recent Charcot-Marie-Tooth research and priorities [v1; ref status: indexed, http://f1000r.es/53g]

by Sean Ekins, Nadia K. Litterman, Renée J.G. Arnold, Robert W. Burgess, Joel S. Freundlich, Steven J. Gray, Joseph J. Higgins, Brett Langley, Dianna E. Willis, Lucia Notterpek, David Pleasure, Michael W. Sereda, Allison Moore
Published 2015-02-01

A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister C...

by Paridhi Sukheja, Pradeep Kumar, Nisha Mittal, Shao-Gang Li, Eric Singleton, Riccardo Russo, Alexander L. Perryman, Riju Shrestha, Divya Awasthi, Seema Husain, Patricia Soteropoulos, Roman Brukh, Nancy Connell, Joel S. Freundlich, David Alland, Carol A. Nacy
Published 2017-02-01

Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein.

by Reem R Al Olaby, Laurence Cocquerel, Adam Zemla, Laure Saas, Jean Dubuisson, Jost Vielmetter, Joseph Marcotrigiano, Abdul Ghafoor Khan, Felipe Vences Catalan, Alexander L Perryman, Joel S Freundlich, Stefano Forli, Shoshana Levy, Rod Balhorn, Hassan M Azzazy
Published 2014-01-01

Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs.

by Richard C Lavin, Calvin Johnson, Yong-Mo Ahn, Kyle M Kremiller, Matthew Sherwood, Jimmy S Patel, Yan Pan, Riccardo Russo, Nathan J MacGilvary, David Giacalone, Yuzo L Kevorkian, Matthew D Zimmerman, J Fraser Glickman, Joel S Freundlich, Shumin Tan
Published 2021-07-01

Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA

by Pradeep Kumar, Glenn C. Capodagli, Divya Awasthi, Riju Shrestha, Karishma Maharaja, Paridhi Sukheja, Shao-Gang Li, Daigo Inoyama, Matthew Zimmerman, Hsin Pin Ho Liang, Jansy Sarathy, Marizel Mina, George Rasic, Riccardo Russo, Alexander L. Perryman, Todd Richmann, Aditi Gupta, Eric Singleton, Sheetal Verma, Seema Husain, Patricia Soteropoulos, Zhe Wang, Roxanne Morris, Gene Porter, Gautam Agnihotri, Padmini Salgame, Sean Ekins, Kyu Y. Rhee, Nancy Connell, Véronique Dartois, Matthew B. Neiditch, Joel S. Freundlich, David Alland
Published 2018-12-01