Whole-brain three-dimensional imaging for quantification of drug targets and treatment effects in mouse models of neurodegenerative diseases

by Henrik H Hansen, Urmas Roostalu, Jacob Hecksher-Sørensen
Published 2020-01-01

Pdx1 is post-translationally modified in vivo and serine 61 is the principal site of phosphorylation.

by Thomas Frogne, Kathrine Beck Sylvestersen, Stefan Kubicek, Michael Lund Nielsen, Jacob Hecksher-Sørensen
Published 2012-01-01

3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II

by Urmas Roostalu, Jacob Lercke Skytte, Casper Gravesen Salinas, Thomas Klein, Niels Vrang, Jacob Jelsing, Jacob Hecksher-Sørensen
Published 2020-12-01

Deep learning reveals 3D atherosclerotic plaque distribution and composition

by Vanessa Isabell Jurtz, Grethe Skovbjerg, Casper Gravesen Salinas, Urmas Roostalu, Louise Pedersen, Jacob Hecksher-Sørensen, Bidda Rolin, Michael Nyberg, Martijn van de Bunt, Camilla Ingvorsen
Published 2020-12-01

Whole-brain activation signatures of weight-lowering drugs

by Henrik H. Hansen, Johanna Perens, Urmas Roostalu, Jacob Lercke Skytte, Casper Gravesen Salinas, Pernille Barkholt, Ditte Dencker Thorbek, Kristoffer T.G. Rigbolt, Niels Vrang, Jacob Jelsing, Jacob Hecksher-Sørensen
Published 2021-05-01

Effect of captopril on post-infarction remodelling visualized by light sheet microscopy and echocardiography

by Urmas Roostalu, Louise Thisted, Jacob Lercke Skytte, Casper Gravesen Salinas, Philip Juhl Pedersen, Jacob Hecksher-Sørensen, Bidda Rolin, Henrik H. Hansen, James G. MacKrell, Robert M. Christie, Niels Vrang, Jacob Jelsing, Nora Elisabeth Zois
Published 2021-03-01

Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease

by Urmas Roostalu, Casper B. G. Salinas, Ditte D. Thorbek, Jacob L. Skytte, Katrine Fabricius, Pernille Barkholt, Linu M. John, Vanessa Isabell Jurtz, Lotte Bjerre Knudsen, Jacob Jelsing, Niels Vrang, Henrik H. Hansen, Jacob Hecksher-Sørensen
Published 2019-11-01

The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells.

by Monica Courtney, Elisabet Gjernes, Noémie Druelle, Christophe Ravaud, Andhira Vieira, Nouha Ben-Othman, Anja Pfeifer, Fabio Avolio, Gunter Leuckx, Sandra Lacas-Gervais, Fanny Burel-Vandenbos, Damien Ambrosetti, Jacob Hecksher-Sorensen, Philippe Ravassard, Harry Heimberg, Ahmed Mansouri, Patrick Collombat
Published 2013-10-01

The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE−/− and LDLr−/− Mice by a Mechanism That Includes Inflammatory Pathways

by Günaj Rakipovski, PhD, Bidda Rolin, DVM, Jane Nøhr, PhD, Ib Klewe, PhD, Klaus S. Frederiksen, PhD, Robert Augustin, PhD, Jacob Hecksher-Sørensen, PhD, Camilla Ingvorsen, PhD, Joseph Polex-Wolf, PhD, Lotte Bjerre Knudsen, DMSc
Published 2018-12-01

An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation

by Tamara Casteels, Yufeng Zhang, Thomas Frogne, Caterina Sturtzel, Charles-Hugues Lardeau, Ilke Sen, Xiaocheng Liu, Shangyu Hong, Florian M. Pauler, Thomas Penz, Marlene Brandstetter, Charlotte Barbieux, Ekaterine Berishvili, Thomas Heuser, Christoph Bock, Christian G. Riedel, Dirk Meyer, Martin Distel, Jacob Hecksher-Sørensen, Jin Li, Stefan Kubicek
Published 2021-12-01

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates

by Violeta Georgieva Tsonkova, Fredrik Wolfhagen Sand, Xenia Asbæk Wolf, Lars Groth Grunnet, Anna Kirstine Ringgaard, Camilla Ingvorsen, Louise Winkel, Mark Kalisz, Kevin Dalgaard, Christine Bruun, Johannes Josef Fels, Charlotte Helgstrand, Sven Hastrup, Fredrik Kryh Öberg, Erik Vernet, Michael Paolo Bastner Sandrini, Allan Christian Shaw, Carsten Jessen, Mads Grønborg, Jacob Hald, Hanni Willenbrock, Dennis Madsen, Rasmus Wernersson, Lena Hansson, Jan Nygaard Jensen, Annette Plesner, Tomas Alanentalo, Maja Borup Kjær Petersen, Anne Grapin-Botton, Christian Honoré, Jonas Ahnfelt-Rønne, Jacob Hecksher-Sørensen, Philippe Ravassard, Ole D. Madsen, Claude Rescan, Thomas Frogne
Published 2018-02-01