Selection and Characterization of Single Chain Antibody Fragments Specific for Hsp90 as a Potential Cancer Targeting Molecule

by Edyta Petters, Aleksandra Sokolowska-Wedzina, Jacek Otlewski
Published 2015-08-01

Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers.

by Aleksandra Borek, Aleksandra Sokolowska-Wedzina, Grzegorz Chodaczek, Jacek Otlewski
Published 2018-01-01

Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity

by Łukasz Opaliński, Aleksandra Sokołowska-Wędzina, Martyna Szczepara, Małgorzata Zakrzewska, Jacek Otlewski
Published 2017-08-01

Stable Fibroblast Growth Factor 2 Dimers with High Pro-Survival and Mitogenic Potential

by Daria Nawrocka, Mateusz Adam Krzyscik, Łukasz Opaliński, Malgorzata Zakrzewska, Jacek Otlewski
Published 2020-06-01

Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling

by Malgorzata Zakrzewska, Lukasz Opalinski, Ellen M. Haugsten, Jacek Otlewski, Antoni Wiedlocha
Published 2019-04-01

FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1

by Karolina Weronika Świderska, Anna Szlachcic, Łukasz Opaliński, Małgorzata Zakrzewska, Jacek Otlewski
Published 2018-07-01

Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment

by Natalia Porębska, Marta Latko, Marika Kucińska, Małgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński
Published 2018-12-01

High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1

by Łukasz Opaliński, Jakub Szymczyk, Martyna Szczepara, Marika Kucińska, Daniel Krowarsch, Małgorzata Zakrzewska, Jacek Otlewski
Published 2018-05-01

Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity

by Anna Szlachcic, Martyna Sochacka, Aleksandra Czyrek, Lukasz Opalinski, Daniel Krowarsch, Jacek Otlewski, Malgorzata Zakrzewska
Published 2019-08-01

Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins

by Marta Latko, Aleksandra Czyrek, Natalia Porębska, Marika Kucińska, Jacek Otlewski, Małgorzata Zakrzewska, Łukasz Opaliński
Published 2019-05-01

Design and In Vitro Evaluation of a Cytotoxic Conjugate Based on the Anti-HER2 Affibody Fused to the Fc Fragment of IgG1

by Alicja M. Sochaj-Gregorczyk, Patryk Ludzia, Emilia Kozdrowska, Piotr Jakimowicz, Aleksandra Sokolowska-Wedzina, Jacek Otlewski
Published 2017-08-01

Specific Antibody Fragment Ligand Traps Blocking FGF1 Activity

by Julia Chudzian, Anna Szlachcic, Malgorzata Zakrzewska, Miroslawa Czub, Marcin Pustula, Tad A. Holak, Jacek Otlewski
Published 2018-08-01

FGF2-Derived PeptibodyF2-MMAE Conjugate for Targeted Delivery of Cytotoxic Drugs into Cancer Cells Overexpressing FGFR1

by Karolina Jendryczko, Julia Chudzian, Natalia Skinder, Łukasz Opaliński, Jakub Rzeszótko, Antoni Wiedlocha, Jacek Otlewski, Anna Szlachcic
Published 2020-10-01

Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins

by Marika Kucińska, Natalia Porębska, Agata Lampart, Marta Latko, Agata Knapik, Małgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński
Published 2019-06-01

A Conjugate Based on Anti-HER2 Diaffibody and Auristatin E Targets HER2-Positive Cancer Cells

by Anna M. Serwotka-Suszczak, Alicja M. Sochaj-Gregorczyk, Jerzy Pieczykolan, Daniel Krowarsch, Filip Jelen, Jacek Otlewski
Published 2017-02-01

Correction: Serwotka-Suszczak, A. M. et al. A Conjugate Based on Anti-HER2 Diaffibody and Auristatin E Targets HER2-Positive Cancer Cells. <em>Int. J. Mol. Sci.</em> 2017, <em>18</...

by Anna M. Serwotka-Suszczak, Alicja M. Sochaj-Gregorczyk, Jerzy Pieczykolan, Daniel Krowarsch, Filip Jelen, Jacek Otlewski
Published 2018-11-01

FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner

by Martyna Sochacka, Lukasz Opalinski, Jakub Szymczyk, Marta B. Zimoch, Aleksandra Czyrek, Daniel Krowarsch, Jacek Otlewski, Malgorzata Zakrzewska
Published 2020-05-01

FGF1 Fusions with the Fc Fragment of IgG1 for the Assembly of GFPpolygons-Mediated Multivalent Complexes Recognizing FGFRs

by Marta Poźniak, Weronika Zarzycka, Natalia Porębska, Agata Knapik, Paulina Marczakiewicz-Perera, Malgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński
Published 2021-07-01

Purification and In Vitro Evaluation of an Anti-HER2 Affibody-Monomethyl Auristatin E Conjugate in HER2-Positive Cancer Cells

by Isabella Damiani, Silvia Castiglioni, Alicja Sochaj-Gregorczyk, Fabrizia Bonacina, Irma Colombo, Valentina Rusconi, Jacek Otlewski, Alberto Corsini, Stefano Bellosta
Published 2021-08-01

Nucleolin regulates phosphorylation and nuclear export of fibroblast growth factor 1 (FGF1).

by Torunn Sletten, Michal Kostas, Joanna Bober, Vigdis Sorensen, Mandana Yadollahi, Sjur Olsnes, Justyna Tomala, Jacek Otlewski, Malgorzata Zakrzewska, Antoni Wiedlocha
Published 2014-01-01