Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity

by Łukasz Opaliński, Aleksandra Sokołowska-Wędzina, Martyna Szczepara, Małgorzata Zakrzewska, Jacek Otlewski
Published 2017-08-01

Stable Fibroblast Growth Factor 2 Dimers with High Pro-Survival and Mitogenic Potential

by Daria Nawrocka, Mateusz Adam Krzyscik, Łukasz Opaliński, Malgorzata Zakrzewska, Jacek Otlewski
Published 2020-06-01

Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling

by Malgorzata Zakrzewska, Lukasz Opalinski, Ellen M. Haugsten, Jacek Otlewski, Antoni Wiedlocha
Published 2019-04-01

FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1

by Karolina Weronika Świderska, Anna Szlachcic, Łukasz Opaliński, Małgorzata Zakrzewska, Jacek Otlewski
Published 2018-07-01

Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment

by Natalia Porębska, Marta Latko, Marika Kucińska, Małgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński
Published 2018-12-01

High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1

by Łukasz Opaliński, Jakub Szymczyk, Martyna Szczepara, Marika Kucińska, Daniel Krowarsch, Małgorzata Zakrzewska, Jacek Otlewski
Published 2018-05-01

Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity

by Anna Szlachcic, Martyna Sochacka, Aleksandra Czyrek, Lukasz Opalinski, Daniel Krowarsch, Jacek Otlewski, Malgorzata Zakrzewska
Published 2019-08-01

Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins

by Marta Latko, Aleksandra Czyrek, Natalia Porębska, Marika Kucińska, Jacek Otlewski, Małgorzata Zakrzewska, Łukasz Opaliński
Published 2019-05-01

FGF2-Derived PeptibodyF2-MMAE Conjugate for Targeted Delivery of Cytotoxic Drugs into Cancer Cells Overexpressing FGFR1

by Karolina Jendryczko, Julia Chudzian, Natalia Skinder, Łukasz Opaliński, Jakub Rzeszótko, Antoni Wiedlocha, Jacek Otlewski, Anna Szlachcic
Published 2020-10-01

Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins

by Marika Kucińska, Natalia Porębska, Agata Lampart, Marta Latko, Agata Knapik, Małgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński
Published 2019-06-01

FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner

by Martyna Sochacka, Lukasz Opalinski, Jakub Szymczyk, Marta B. Zimoch, Aleksandra Czyrek, Daniel Krowarsch, Jacek Otlewski, Malgorzata Zakrzewska
Published 2020-05-01

Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis

by Łukasz Opaliński, Jiyao Song, Chantal Priesnitz, Lena-Sophie Wenz, Silke Oeljeklaus, Bettina Warscheid, Nikolaus Pfanner, Thomas Becker
Published 2018-11-01

FGF1 Fusions with the Fc Fragment of IgG1 for the Assembly of GFPpolygons-Mediated Multivalent Complexes Recognizing FGFRs

by Marta Poźniak, Weronika Zarzycka, Natalia Porębska, Agata Knapik, Paulina Marczakiewicz-Perera, Malgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński
Published 2021-07-01

The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells

by Marta Poźniak, Natalia Porębska, Mateusz Adam Krzyścik, Aleksandra Sokołowska-Wędzina, Kamil Jastrzębski, Martyna Sochacka, Jakub Szymczyk, Małgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński
Published 2021-05-01

De novo peroxisome biogenesis in Penicillium chrysogenum is not dependent on the Pex11 family members or Pex16.

by Łukasz Opaliński, Magdalena Bartoszewska, Susan Fekken, Haiyin Liu, Rinse de Boer, Ida van der Klei, Marten Veenhuis, Jan A K W Kiel
Published 2012-01-01

FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization

by Marta Pozniak, Aleksandra Sokolowska‐Wedzina, Kamil Jastrzebski, Jakub Szymczyk, Natalia Porebska, Mateusz Adam Krzyscik, Malgorzata Zakrzewska, Marta Miaczynska, Jacek Otlewski, Lukasz Opalinski
Published 2020-09-01

The Mitochondrial Import Complex MIM Functions as Main Translocase for α-Helical Outer Membrane Proteins

by Kim Nguyen Doan, Alexander Grevel, Christoph U. Mårtensson, Lars Ellenrieder, Nicolas Thornton, Lena-Sophie Wenz, Łukasz Opaliński, Bernard Guiard, Nikolaus Pfanner, Thomas Becker
Published 2020-04-01

Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10

by Lars Ellenrieder, Łukasz Opaliński, Lars Becker, Vivien Krüger, Oliver Mirus, Sebastian P. Straub, Katharina Ebell, Nadine Flinner, Sebastian B. Stiller, Bernard Guiard, Chris Meisinger, Nils Wiedemann, Enrico Schleiff, Richard Wagner, Nikolaus Pfanner, Thomas Becker
Published 2016-10-01