Pleiotropic Effects of mTOR and Autophagy During Development and Aging

by Kathrin Schmeisser, J. Alex Parker
Published 2019-09-01

Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy.

by Kathrin Schmeisser, J Alex Parker
Published 2018-09-01

Heritable transmission of stress resistance by high dietary glucose in Caenorhabditis elegans.

by Arnaud Tauffenberger, J Alex Parker
Published 2014-05-01

Worming forward: amyotrophic lateral sclerosis toxicity mechanisms and genetic interactions in Caenorhabditis elegans

by Martine eTherrien, J Alex Parker
Published 2014-04-01

Rescue of ATXN3 neuronal toxicity in Caenorhabditis elegans by chemical modification of endoplasmic reticulum stress

by Yasmin Fardghassemi, Arnaud Tauffenberger, Sarah Gosselin, J. Alex Parker
Published 2017-12-01

Deletion of C9ORF72 results in motor neuron degeneration and stress sensitivity in C. elegans.

by Martine Therrien, Guy A Rouleau, Patrick A Dion, J Alex Parker
Published 2013-01-01

Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans.

by Alexandra Vaccaro, Arnaud Tauffenberger, Dina Aggad, Guy Rouleau, Pierre Drapeau, J Alex Parker
Published 2012-01-01

TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans.

by Alexandra Vaccaro, Arnaud Tauffenberger, Peter E A Ash, Yari Carlomagno, Leonard Petrucelli, J Alex Parker
Published 2012-07-01

Cross-talk between canonical Wnt signaling and the sirtuin-FoxO longevity pathway to protect against muscular pathology induced by mutant PABPN1 expression in C. elegans

by Matthieu Y. Pasco, Hélène Catoire, J. Alex Parker, Bernard Brais, Guy A. Rouleau, Christian Néri
Published 2010-06-01

Modulating the endoplasmic reticulum stress response attenuates neurodegeneration in a Caenorhabditis elegans model of spinal muscular atrophy

by James J. Doyle, Celine Vrancx, Claudia Maios, Audrey Labarre, Shunmoogum A. Patten, J. Alex Parker
Published 2020-12-01

Fishing for causes and cures of motor neuron disorders

by Shunmoogum A. Patten, Gary A. B. Armstrong, Alexandra Lissouba, Edor Kabashi, J. Alex Parker, Pierre Drapeau
Published 2014-07-01

Methylene blue protects against TDP-43 and FUS neuronal toxicity in C. elegans and D. rerio.

by Alexandra Vaccaro, Shunmoogum A Patten, Sorana Ciura, Claudia Maios, Martine Therrien, Pierre Drapeau, Edor Kabashi, J Alex Parker
Published 2012-01-01

Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo

by Alexandra Vaccaro, Shunmoogum A. Patten, Dina Aggad, Carl Julien, Claudia Maios, Edor Kabashi, Pierre Drapeau, J. Alex Parker
Published 2013-07-01

The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington’s disease

by Francesca Farina, Emmanuel Lambert, Lucie Commeau, François-Xavier Lejeune, Nathalie Roudier, Cosima Fonte, J. Alex Parker, Jacques Boddaert, Marc Verny, Etienne-Emile Baulieu, Christian Neri
Published 2017-06-01

The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity.

by Cendrine Tourette, Francesca Farina, Rafael P Vazquez-Manrique, Anne-Marie Orfila, Jessica Voisin, Sonia Hernandez, Nicolas Offner, J Alex Parker, Sophie Menet, Jinho Kim, Jungmok Lyu, Si Ho Choi, Kerry Cormier, Christina K Edgerly, Olivia L Bordiuk, Karen Smith, Anne Louise, Michael Halford, Steven Stacker, Jean-Philippe Vert, Robert J Ferrante, Wange Lu, Christian Neri
Published 2014-06-01