Combination of a Latency-Reversing Agent With a Smac Mimetic Minimizes Secondary HIV-1 Infection in vitro

by Shin-ichiro Hattori, Kouki Matsuda, Kiyoto Tsuchiya, Hiroyuki Gatanaga, Shinichi Oka, Kazuhisa Yoshimura, Hiroaki Mitsuya, Hiroaki Mitsuya, Kenji Maeda
Published 2018-09-01

Successful Treatment of Cisplatin Overdose with Plasma Exchange

by Yasuhiro Yamada, Yoshiaki Ikuta, Kisato Nosaka, Nobutomo Miyanari, Naoko Hayashi, Hiroaki Mitsuya, Hideo Baba
Published 2010-01-01

A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators

by Kouki Matsuda, Takuya Kobayakawa, Ryusho Kariya, Kiyoto Tsuchiya, Shoraku Ryu, Kohei Tsuji, Takahiro Ishii, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Kazuhisa Yoshimura, Seiji Okada, Akinobu Hamada, Hiroaki Mitsuya, Hiroaki Mitsuya, Hirokazu Tamamura, Kenji Maeda
Published 2021-03-01

Pharmacokinetic properties of a novel inosine analog, 4'-cyano-2'-deoxyinosine, after oral administration in rats.

by Mai Hashimoto, Kazuaki Taguchi, Takako Ishiguro, Satoru Kohgo, Shuhei Imoto, Keishi Yamasaki, Hiroaki Mitsuya, Masaki Otagiri
Published 2018-01-01

Mechanism of Darunavir (DRV)’s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV...

by Manabu Aoki, Debananda Das, Hironori Hayashi, Hiromi Aoki-Ogata, Yuki Takamatsu, Arun K. Ghosh, Hiroaki Mitsuya, Vinayaka R. Prasad
Published 2018-03-01

Effects of islatravir (4′-ethynyl-2-fluoro-2′-deoxyadenosine or EFdA) on renal tubular cells and islatravir's interactions with organic anion transporters

by Meika Kaneko, Yoshie Reien, Hanae Morio, Tomoko Fukuuchi, Kiyoko Kaneko, Yuri Hirayama, Hirofumi Hashimoto, Nobuyo Kuwata, Hiroaki Mitsuya, Naohiko Anzai
Published 2021-06-01

Increase of C1q biosynthesis in brain microglia and macrophages during lentivirus infection in the rhesus macaque is sensitive to antiretroviral treatment with 6-chloro-2′,3′-dideo...

by Candan Depboylu, Martin K.-H. Schäfer, Wilhelm J. Schwaeble, Todd A. Reinhart, Hitomi Maeda, Hiroaki Mitsuya, Ruslan Damadzic, Dianne M. Rausch, Lee E. Eiden, Eberhard Weihe
Published 2005-10-01

Neutralization of SARS-CoV-2 with IgG from COVID-19-convalescent plasma

by Kenji Maeda, Nobuyo Higashi-Kuwata, Noriko Kinoshita, Satoshi Kutsuna, Kiyoto Tsuchiya, Shin-ichiro Hattori, Kouki Matsuda, Yuki Takamatsu, Hiroyuki Gatanaga, Shinichi Oka, Haruhito Sugiyama, Norio Ohmagari, Hiroaki Mitsuya
Published 2021-03-01

A novel highly quantitative and reproducible assay for the detection of anti-SARS-CoV-2 IgG and IgM antibodies

by Kenta Noda, Kouki Matsuda, Shigehiro Yagishita, Kenji Maeda, Yutaro Akiyama, Junko Terada-Hirashima, Hiromichi Matsushita, Satoshi Iwata, Kazuto Yamashita, Yusuke Atarashi, Shunsuke Watanabe, Nobuyuki Ide, Tomokazu Yoshida, Norio Ohmagari, Hiroaki Mitsuya, Akinobu Hamada
Published 2021-03-01

GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection

by Shin-ichiro Hattori, Nobuyo Higshi-Kuwata, Jakka Raghavaiah, Debananda Das, Haydar Bulut, David A. Davis, Yuki Takamatsu, Kouki Matsuda, Nobutoki Takamune, Naoki Kishimoto, Tadashi Okamura, Shogo Misumi, Robert Yarchoan, Kenji Maeda, Arun K. Ghosh, Hiroaki Mitsuya
Published 2020-08-01

Switching tenofovir/emtricitabine plus lopinavir/r to raltegravir plus Darunavir/r in patients with suppressed viral load did not result in improvement of renal function but could...

by Takeshi Nishijima, Hiroyuki Gatanaga, Takuro Shimbo, Hirokazu Komatsu, Tomoyuki Endo, Masahide Horiba, Michiko Koga, Toshio Naito, Ichiro Itoda, Masanori Tei, Teruhisa Fujii, Kiyonori Takada, Masahiro Yamamoto, Toshikazu Miyakawa, Yoshinari Tanabe, Hiroaki Mitsuya, Shinichi Oka, SPARE study team
Published 2013-01-01

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

by Manabu Aoki, Hironori Hayashi, Kalapala Venkateswara Rao, Debananda Das, Nobuyo Higashi-Kuwata, Haydar Bulut, Hiromi Aoki-Ogata, Yuki Takamatsu, Ravikiran S Yedidi, David A Davis, Shin-ichiro Hattori, Noriko Nishida, Kazuya Hasegawa, Nobutoki Takamune, Prasanth R Nyalapatla, Heather L Osswald, Hirofumi Jono, Hideyuki Saito, Robert Yarchoan, Shogo Misumi, Arun K Ghosh, Hiroaki Mitsuya
Published 2017-10-01

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

by Shin-ichiro Hattori, Nobuyo Higashi-Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Haydar Bulut, Debananda Das, Brandon J. Anson, Emma K. Lendy, Yuki Takamatsu, Nobutoki Takamune, Naoki Kishimoto, Kazutaka Murayama, Kazuya Hasegawa, Mi Li, David A. Davis, Eiichi N. Kodama, Robert Yarchoan, Alexander Wlodawer, Shogo Misumi, Andrew D. Mesecar, Arun K. Ghosh, Hiroaki Mitsuya
Published 2021-01-01

Comparison of Rapid Antigen Tests for COVID-19

by Seiya Yamayoshi, Yuko Sakai-Tagawa, Michiko Koga, Osamu Akasaka, Ichiro Nakachi, Hidefumi Koh, Kenji Maeda, Eisuke Adachi, Makoto Saito, Hiroyuki Nagai, Kazuhiko Ikeuchi, Takayuki Ogura, Rie Baba, Kensuke Fujita, Takahiro Fukui, Fumimaro Ito, Shin-ichiro Hattori, Kei Yamamoto, Takato Nakamoto, Yuri Furusawa, Atsuhiro Yasuhara, Michiko Ujie, Shinya Yamada, Mutsumi Ito, Hiroaki Mitsuya, Norio Omagari, Hiroshi Yotsuyanagi, Kiyoko Iwatsuki-Horimoto, Masaki Imai, Yoshihiro Kawaoka
Published 2020-12-01

Antibody titers against SARS-CoV-2 decline, but do not disappear for several months

by Seiya Yamayoshi, Atsuhiro Yasuhara, Mutsumi Ito, Osamu Akasaka, Morio Nakamura, Ichiro Nakachi, Michiko Koga, Keiko Mitamura, Kazuma Yagi, Kenji Maeda, Hideaki Kato, Masanori Nojima, David Pattinson, Takayuki Ogura, Rie Baba, Kensuke Fujita, Hiroyuki Nagai, Shinya Yamamoto, Makoto Saito, Eisuke Adachi, Junichi Ochi, Shin-ichiro Hattori, Tetsuya Suzuki, Yusuke Miyazato, Shiho Chiba, Moe Okuda, Jurika Murakami, Taiki Hamabata, Kiyoko Iwatsuki-Horimoto, Hideaki Nakajima, Hiroaki Mitsuya, Norio Omagari, Norio Sugaya, Hiroshi Yotsuyanagi, Yoshihiro Kawaoka
Published 2021-02-01