A lethal mouse model using a mouse-adapted SARS-CoV-2 strain with enhanced binding to mouse ACE2 as an important platform for COVID-19 research

by Hin Chu, Jasper Fuk-Woo Chan
Published 2021-06-01

Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2

by Lihong Huang, Terrence Tsz-Tai Yuen, Zuodong Ye, Shuyan Liu, Guoliang Zhang, Hin Chu, Jianbo Yue
Published 2021-04-01

The intracellular virus-containing compartments in primary human macrophages are largely inaccessible to antibodies and small molecules.

by Hin Chu, Jaang-Jiun Wang, Mingli Qi, Jeong-Joong Yoon, Xiaoyun Wen, Xuemin Chen, Lingmei Ding, Paul Spearman
Published 2012-01-01

Therapeutic potential and mechanism of Dendrobium officinale polysaccharides on cigarette smoke-induced airway inflammation in rat

by Yingmin Liang, Ruixuan Du, Rui Chen, Pak Hin Chu, Mary Sau Man Ip, Kalin Yan Bo Zhang, Judith Choi Wo Mak
Published 2021-11-01

Development of Three-Dimensional Human Intestinal Organoids as a Physiologically Relevant Model for Characterizing the Viral Replication Kinetics and Antiviral Susceptibility of En...

by Jessica Oi-Ling Tsang, Jie Zhou, Xiaoyu Zhao, Cun Li, Zijiao Zou, Feifei Yin, Shuofeng Yuan, Man-Lung Yeung, Hin Chu, Jasper Fuk-Woo Chan
Published 2021-01-01

Rab11-FIP1C and Rab14 direct plasma membrane sorting and particle incorporation of the HIV-1 envelope glycoprotein complex.

by Mingli Qi, Janice A Williams, Hin Chu, Xuemin Chen, Jaang-Jiun Wang, Lingmei Ding, Ehiole Akhirome, Xiaoyun Wen, Lynne A Lapierre, James R Goldenring, Paul Spearman
Published 2013-01-01

A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

by Hanjun Zhao, Kelvin K. W. To, Kong-Hung Sze, Timothy Tin-Mong Yung, Mingjie Bian, Hoiyan Lam, Man Lung Yeung, Cun Li, Hin Chu, Kwok-Yung Yuen
Published 2020-08-01

Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza

by Hanjun Zhao, Kelvin K. W. To, Hin Chu, Qiulu Ding, Xiaoyu Zhao, Cun Li, Huiping Shuai, Shuofeng Yuan, Jie Zhou, Kin-Hang Kok, Shibo Jiang, Kwok-Yung Yuen
Published 2018-06-01

Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication

by Bingpeng Yan, Hin Chu, Dong Yang, Kong-Hung Sze, Pok-Man Lai, Shuofeng Yuan, Huiping Shuai, Yixin Wang, Richard Yi-Tsun Kao, Jasper Fuk-Woo Chan, Kwok-Yung Yuen
Published 2019-01-01

Intradermal vaccination of live attenuated influenza vaccine protects mice against homologous and heterologous influenza challenges

by Andrew Chak-Yiu Lee, Anna Jinxia Zhang, Can Li, Yanxia Chen, Feifei Liu, Yan Zhao, Hin Chu, Carol Ho-Yan Fong, Pui Wang, Siu-Ying Lau, Kelvin Kai-Wang To, Honglin Chen, Kwok-Yung Yuen
Published 2021-08-01

Metabolic Profiling Reveals Significant Perturbations of Intracellular Glucose Homeostasis in <i>Enterovirus</i>-Infected Cells

by Zijiao Zou, Jessica Oi-Ling Tsang, Bingpeng Yan, Kenn Ka-Heng Chik, Chris Chun-Yiu Chan, Jianli Cao, Ronghui Liang, Kaiming Tang, Feifei Yin, Zi-Wei Ye, Hin Chu, Jasper Fuk-Woo Chan, Shuofeng Yuan, Kwok-Yung Yuen
Published 2020-07-01

Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy

by Zheng Zhu, Hin Chu, Lei Wen, Shuofeng Yuan, Kenn Ka-Heng Chik, Terrence Tsz-Tai Yuen, Cyril Chik-Yan Yip, Dong Wang, Jie Zhou, Feifei Yin, Dong-Yan Jin, Kin-Hang Kok, Kwok-Yung Yuen, Jasper Fuk-Woo Chan
Published 2019-01-01

Identification and characterization of GLDC as host susceptibility gene to severe influenza

by Jie Zhou, Dong Wang, Bosco Ho‐Yin Wong, Cun Li, Vincent Kwok‐Man Poon, Lei Wen, Xiaoyu Zhao, Man Chun Chiu, Xiaojuan Liu, Ziwei Ye, Shuofeng Yuan, Kong‐Hung Sze, Jasper Fuk‐Woo Chan, Hin Chu, Kelvin Kai‐Wang To, Kwok Yung Yuen
Published 2019-01-01

Repurposing of Miltefosine as an Adjuvant for Influenza Vaccine

by Lu Lu, Carol Ho-Yan Fong, Anna Jinxia Zhang, Wai-Lan Wu, Iris Can Li, Andrew Chak-Yiu Lee, Thrimendra Kaushika Dissanayake, Linlei Chen, Ivan Fan-Ngai Hung, Kwok-Hung Chan, Hin Chu, Kin-Hang Kok, Kwok-Yung Yuen, Kelvin Kai-Wang To
Published 2020-12-01

Adenosine synthase A contributes to recurrent Staphylococcus aureus infection by dampening protective immunity

by Jian Deng, Bao-zhong Zhang, Hin Chu, Xiao-lei Wang, Yixin Wang, Hua-Rui Gong, Renhao Li, Dong Yang, Cun Li, Ying Dou, Peng Gao, Jian-piao Cai, Meilin Jin, Qian Du, Jasper Fuk-Woo Chan, Richard Yi-Tsun Kao, Kwok-Yung Yuen, Jian-Dong Huang
Published 2021-08-01

Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters

by Andrew Chak-Yiu Lee, Anna Jinxia Zhang, Jasper Fuk-Woo Chan, Can Li, Zhimeng Fan, Feifei Liu, Yanxia Chen, Ronghui Liang, Siddharth Sridhar, Jian-Piao Cai, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Kelvin Kai-Wang To, Shuofeng Yuan, Jie Zhou, Hin Chu, Kwok-Yung Yuen
Published 2020-10-01

Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)

by Shuofeng Yuan, Chris Chun-Yiu Chan, Kenn Ka-Heng Chik, Jessica Oi-Ling Tsang, Ronghui Liang, Jianli Cao, Kaiming Tang, Jian-Piao Cai, Zi-Wei Ye, Feifei Yin, Kelvin Kai-Wang To, Hin Chu, Dong-Yan Jin, Ivan Fan-Ngai Hung, Kwok-Yung Yuen, Jasper Fuk-Woo Chan
Published 2020-06-01

Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus

by Shuofeng Yuan, Jasper Fuk-Woo Chan, Zi-Wei Ye, Lei Wen, Terance Gi-Wai Tsang, Jianli Cao, Jingjing Huang, Chris Chun-Yiu Chan, Kenn Ka-Heng Chik, Garnet Kwan-Yue Choi, Jian-Piao Cai, Feifei Yin, Hin Chu, Mifang Liang, Dong-Yan Jin, Kwok-Yung Yuen
Published 2019-04-01

SARS-CoV-2 Induces a More Robust Innate Immune Response and Replicates Less Efficiently Than SARS-CoV in the Human Intestines: An Ex Vivo Study With Implications on Pathogenesis of...

by Hin Chu, Jasper Fuk-Woo Chan, Yixin Wang, Terrence Tsz-Tai Yuen, Yue Chai, Huiping Shuai, Dong Yang, Bingjie Hu, Xiner Huang, Xi Zhang, Yuxin Hou, Jian-Piao Cai, Anna Jinxia Zhang, Jie Zhou, Shuofeng Yuan, Kelvin Kai-Wang To, Ivan Fan-Ngai Hung, Tan To Cheung, Ada Tsui-Lin Ng, Ivy Hau-Yee Chan, Ian Yu-Hong Wong, Simon Ying-Kit Law, Dominic Chi-Chung Foo, Wai-Keung Leung, Kwok-Yung Yuen
Published 2021-01-01

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

by Shuofeng Yuan, Hin Chu, Jasper Fuk-Woo Chan, Zi-Wei Ye, Lei Wen, Bingpeng Yan, Pok-Man Lai, Kah-Meng Tee, Jingjing Huang, Dongdong Chen, Cun Li, Xiaoyu Zhao, Dong Yang, Man Chun Chiu, Cyril Yip, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Kong-Hung Sze, Jie Zhou, Ivy Hau-Yee Chan, Kin-Hang Kok, Kelvin Kai-Wang To, Richard Yi-Tsun Kao, Johnson Yiu-Nam Lau, Dong-Yan Jin, Stanley Perlman, Kwok-Yung Yuen
Published 2019-01-01