Comparative therapeutic effects of velaglucerase alfa and imiglucerase in a Gaucher disease mouse model.

by You-Hai Xu, Ying Sun, Sonya Barnes, Gregory A Grabowski
Published 2010-05-01

Multi-system disorders of glycosphingolipid and ganglioside metabolism

by You-Hai Xu, Sonya Barnes, Ying Sun, Gregory A. Grabowski
Published 2010-07-01

Gaucher disease mouse models: point mutations at the acid β-glucosidase locus combined with low-level prosaposin expression lead to disease variants

by Ying Sun, Brian Quinn, David P. Witte, Gregory A. Grabowski
Published 2005-10-01

In vivo and ex vivo evaluation of L-type calcium channel blockers on acid beta-glucosidase in Gaucher disease mouse models.

by Ying Sun, Benjamin Liou, Brian Quinn, Huimin Ran, You-Hai Xu, Gregory A Grabowski
Published 2009-10-01

Conditional expression of human acid β-glucosidase improves the visceral phenotype in a Gaucher disease mouse model

by Ying Sun, Brian Quinn, You-Hai Xu, Tatyana Leonova, David P. Witte, Gregory A. Grabowski
Published 2006-10-01

Gaucher disease: transcriptome analyses using microarray or mRNA sequencing in a Gba1 mutant mouse model treated with velaglucerase alfa or imiglucerase.

by Nupur Dasgupta, You-Hai Xu, Sunghee Oh, Ying Sun, Li Jia, Mehdi Keddache, Gregory A Grabowski
Published 2013-01-01

Lysosomal acid lipase-deficient mice: depletion of white and brown fat, severe hepatosplenomegaly, and shortened life span

by Hong Du, Martin Heur, Ming Duanmu, Gregory A. Grabowski, David Y. Hui, David P. Witte, Jaya Mishra
Published 2001-04-01

Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease.

by Mei Dai, Benjamin Liou, Brittany Swope, Xiaohong Wang, Wujuan Zhang, Venette Inskeep, Gregory A Grabowski, Ying Sun, Dao Pan
Published 2016-01-01

Substrate compositional variation with tissue/region and Gba1 mutations in mouse models--implications for Gaucher disease.

by Ying Sun, Wujuan Zhang, You-Hai Xu, Brian Quinn, Nupur Dasgupta, Benjamin Liou, Kenneth D R Setchell, Gregory A Grabowski
Published 2013-01-01

Systemic enzyme delivery by blood-brain barrier-penetrating SapC-DOPS nanovesicles for treatment of neuronopathic Gaucher disease

by Ying Sun, Benjamin Liou, Zhengtao Chu, Venette Fannin, Rachel Blackwood, Yanyan Peng, Gregory A. Grabowski, Harold W. Davis, Xiaoyang Qi
Published 2020-05-01

Ubiquitous transgene expression of the glucosylceramide-synthesizing enzyme accelerates glucosylceramide accumulation and storage cells in a Gaucher disease mouse model.

by Sonya Barnes, You-Hai Xu, Wujuan Zhang, Benjamin Liou, Kenneth D R Setchell, Liming Bao, Gregory A Grabowski, Ying Sun
Published 2014-01-01

Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophages

by DongFang Wu, Chakradhari Sharan, Hong Yang, J. Shawn Goodwin, Lichun Zhou, Gregory A. Grabowski, Hong Du, ZhongMao Guo
Published 2007-12-01

Activation of p38 Mitogen-Activated Protein Kinase in Gaucher's Disease.

by Kazuyuki Kitatani, Masayuki Wada, David Perry, Toshinori Usui, Ying Sun, Lina M Obeid, Nobuo Yaegashi, Gregory A Grabowski, Yusuf A Hannun
Published 2015-01-01

Substrate Reduction Therapy Reverses Mitochondrial, mTOR, and Autophagy Alterations in a Cell Model of Gaucher Disease

by Yanyan Peng, Benjamin Liou, Yi Lin, Venette Fannin, Wujuan Zhang, Ricardo A. Feldman, Kenneth D. R. Setchell, Gregory A. Grabowski, Ying Sun
Published 2021-09-01

Wolman disease/cholesteryl ester storage disease: efficacy of plant-produced human lysosomal acid lipase in mice*

by Hong Du, Terri L. Cameron, Stephen J. Garger, Gregory P. Pogue, Lee A. Hamm, Earl White, Kathleen M. Hanley, Gregory A. Grabowski
Published 2008-08-01

Endogenous β-glucocerebrosidase activity in Abca12−/−epidermis elevates ceramide levels after topical lipid application but does not restore barrier function

by Jorge F. Haller, Paul Cavallaro, Nicholas J. Hernandez, Lee Dolat, Stephanie J. Soscia, Ruth Welti, Gregory A. Grabowski, Michael L. Fitzgerald, Mason W. Freeman
Published 2014-03-01

Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse.

by Ying Sun, Huimin Ran, Benjamin Liou, Brian Quinn, Matt Zamzow, Wujuan Zhang, Jacek Bielawski, Kazuyuki Kitatani, Kenneth D R Setchell, Yusuf A Hannun, Gregory A Grabowski
Published 2011-04-01

Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease

by Jinlong Jian, Yuehong Chen, Rossella Liberti, Wenyu Fu, Wenhuo Hu, Rachel Saunders-Pullman, Gregory M. Pastores, Ying Chen, Ying Sun, Gregory A. Grabowski, Chuan-ju Liu
Published 2018-02-01

Properties of neurons derived from induced pluripotent stem cells of Gaucher disease type 2 patient fibroblasts: potential role in neuropathology.

by Ying Sun, Jane Florer, Christopher N Mayhew, Zhanfeng Jia, Zhiying Zhao, Kui Xu, Huimin Ran, Benjamin Liou, Wujuan Zhang, Kenneth D R Setchell, Jianguo Gu, Gregory A Grabowski
Published 2015-01-01

Association Between Progranulin and Gaucher Disease

by Jinlong Jian, Shuai Zhao, Qing-Yun Tian, Helen Liu, Yunpeng Zhao, Wen-Chi Chen, Gabriele Grunig, Paola A. Torres, Betty C. Wang, Bai Zeng, Gregory Pastores, Wei Tang, Ying Sun, Gregory A. Grabowski, Max Xiangtian Kong, Guilin Wang, Ying Chen, Fengxia Liang, Herman S. Overkleeft, Rachel Saunders-Pullman, Gerald L. Chan, Chuan-ju Liu
Published 2016-09-01