Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics

by Kassiani Kytidou, Marta Artola, Marta Artola, Herman S. Overkleeft, Johannes M. F. G. Aerts
Published 2020-04-01

Distinguishing the differences in β-glycosylceramidase folds, dynamics, and actions informs therapeutic uses

by Fredj Ben Bdira, Marta Artola, Herman S. Overkleeft, Marcellus Ubbink, Johannes M.F.G. Aerts
Published 2018-12-01

A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase α

by Tom van der Wel, Freek J. Janssen, Marc P. Baggelaar, Hui Deng, Hans den Dulk, Herman S. Overkleeft, Mario van der Stelt
Published 2015-04-01

Progranulin deficiency leads to reduced glucocerebrosidase activity.

by Xiaolai Zhou, Daniel H Paushter, Mitchell D Pagan, Dongsung Kim, Mariela Nunez Santos, Raquel L Lieberman, Herman S Overkleeft, Ying Sun, Marcus B Smolka, Fenghua Hu
Published 2019-01-01

Skin barrier lipid enzyme activity in Netherton patients is associated with protease activity and ceramide abnormalities[S]

by Jeroen van Smeden, Hanin Al-Khakany, Yichen Wang, Dani Visscher, Nicole Stephens, Samira Absalah, Herman S. Overkleeft, Johannes M.F.G. Aerts, Alain Hovnanian, Joke A. Bouwstra
Published 2020-06-01

Fluorescent Probes from Aromatic Polycyclic Nitrile Oxides: Isoxazoles versus Dihydro‐1λ3,3,2λ4‐Oxazaborinines

by Dr. Mattia Moiola, Dr. Antonio Bova, Dr. Stefano Crespi, Dr. Misal G. Memeo, Prof. Mariella Mella, Prof. Herman S. Overkleeft, Dr. Bogdan I. Florea, Prof. Paolo Quadrelli
Published 2019-06-01

Design, automated synthesis and immunological evaluation of NOD2-ligand–antigen conjugates

by Marian M. J. H. P. Willems, Gijs G. Zom, Nico Meeuwenoord, Ferry A. Ossendorp, Herman S. Overkleeft, Gijsbert A. van der Marel, Jeroen D. C. Codée, Dmitri V. Filippov
Published 2014-06-01

Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis

by Paulo Gaspar, Wouter W. Kallemeijn, Anneke Strijland, Saskia Scheij, Marco Van Eijk, Jan Aten, Herman S. Overkleeft, Andrea Balreira, Friederike Zunke, Michael Schwake, Clara Sá Miranda, JohannesM.F.G. Aerts
Published 2014-01-01

Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease

by Jinlong Jian, Qing-Yun Tian, Aubryanna Hettinghouse, Shuai Zhao, Helen Liu, Jianlu Wei, Gabriele Grunig, Wujuan Zhang, Kenneth D.R. Setchell, Ying Sun, Herman S. Overkleeft, Gerald L. Chan, Chuan-ju Liu
Published 2016-11-01

N-Azidoacetylmannosamine-mediated chemical tagging of gangliosides

by Anton P. Bussink, Paul F. van Swieten, Karen Ghauharali, Saskia Scheij, Marco van Eijk, Tom Wennekes, Gijs A. van der Marel, Rolf G. Boot, Johannes M.F.G. Aerts, Herman S. Overkleeft
Published 2007-07-01

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes.

by Wouter W Kallemeijn, Saskia Scheij, Sascha Hoogendoorn, Martin D Witte, Daniela Herrera Moro Chao, Cindy P A A van Roomen, Roelof Ottenhoff, Herman S Overkleeft, Rolf G Boot, Johannes M F G Aerts
Published 2017-01-01

In situ visualization of glucocerebrosidase in human skin tissue: zymography versus activity-based probe labeling[S]

by Jeroen van Smeden, Irini M. Dijkhoff, Richard W.J. Helder, Hanin Al-Khakany, Daphne E.C. Boer, Anne Schreuder, Wouter W. Kallemeijn, Samira Absalah, Herman S. Overkleeft, Johannes M.F.G. Aerts, Joke A. Bouwstra
Published 2017-12-01

Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism.

by Elisa Lombardo, Cindy P A A van Roomen, Gijs H van Puijvelde, Roelof Ottenhoff, Marco van Eijk, Jan Aten, Johan Kuiper, Herman S Overkleeft, Albert K Groen, Arthur J Verhoeven, Johannes M F G Aerts, Florence Bietrix
Published 2012-01-01

Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain

by Eva J. van Rooden, Annelot C. M. van Esbroeck, Marc P. Baggelaar, Hui Deng, Bogdan I. Florea, André R. A. Marques, Roelof Ottenhoff, Rolf G. Boot, Herman S. Overkleeft, Johannes M. F. G. Aerts, Mario van der Stelt
Published 2018-07-01

1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor

by Marta Artola, Liang Wu, Maria J. Ferraz, Chi-Lin Kuo, Lluís Raich, Imogen Z. Breen, Wendy A. Offen, Jeroen D. C. Codée, Gijsbert A. van der Marel, Carme Rovira, Johannes M. F. G. Aerts, Gideon J. Davies, Herman S. Overkleeft
Published 2017-07-01

Correction to “Detection of Active Mammalian GH31 α‑Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes”

by Jianbing Jiang, Chi-Lin Kuo, Liang Wu, Christian Franke, Wouter W. Kallemeijn, Bogdan I. Florea, Eline van Meel, Gijsbert A. van der Marel, Jeroen D. C. Codée, Rolf G. Boot, Gideon J. Davies, Herman S. Overkleeft, Johannes M. F. G. Aerts
Published 2017-05-01

Detection of Active Mammalian GH31 α‑Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes

by Jianbing Jiang, Chi-Lin Kuo, Liang Wu, Christian Franke, Wouter W. Kallemeijn, Bogdan I. Florea, Eline van Meel, Gijsbert A. van der Marel, Jeroen D. C. Codée, Rolf G. Boot, Gideon J. Davies, Herman S. Overkleeft, Johannes M. F. G. Aerts
Published 2016-04-01

Role of μ-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish

by Lindsey T. Lelieveld, Mina Mirzaian, Chi-Lin Kuo, Marta Artola, Maria J. Ferraz, Remco E.A. Peter, Hisako Akiyama, Peter Greimel, Richard J.B.H.N. van den Berg, Herman S. Overkleeft, Rolf G. Boot, Annemarie H. Meijer, Johannes M.F.G. Aerts
Published 2019-11-01

Identification of α,β-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells

by Annelot C. M. van Esbroeck, Vasudev Kantae, Vasudev Kantae, Xinyu Di, Tom van der Wel, Hans den Dulk, Anna F. Stevens, Simar Singh, Simar Singh, Alexander T. Bakker, Bogdan I. Florea, Nephi Stella, Nephi Stella, Herman S. Overkleeft, Thomas Hankemeier, Mario van der Stelt
Published 2019-11-01

Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease

by Kassiani Kytidou, Thomas J. M. Beenakker, Lotte B. Westerhof, Cornelis H. Hokke, Geri F. Moolenaar, Nora Goosen, Mina Mirzaian, Maria J. Ferraz, Mark de Geus, Wouter W. Kallemeijn, Herman S. Overkleeft, Rolf G. Boot, Arjen Schots, Dirk Bosch, Johannes M. F. G. Aerts
Published 2017-06-01