Quantitatively characterizing the ligand binding mechanisms of choline binding protein using Markov state model analysis.

by Shuo Gu, Daniel-Adriano Silva, Luming Meng, Alexander Yue, Xuhui Huang
Published 2014-08-01

A role for both conformational selection and induced fit in ligand binding by the LAO protein.

by Daniel-Adriano Silva, Gregory R Bowman, Alejandro Sosa-Peinado, Xuhui Huang
Published 2011-05-01

Structural Model of RNA Polymerase II Elongation Complex with Complete Transcription Bubble Reveals NTP Entry Routes.

by Lu Zhang, Daniel-Adriano Silva, Fátima Pardo-Avila, Dong Wang, Xuhui Huang
Published 2015-07-01

Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue

by Lin-Tai Da, Fátima Pardo-Avila, Liang Xu, Daniel-Adriano Silva, Lu Zhang, Xin Gao, Dong Wang, Xuhui Huang
Published 2016-04-01

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

by Stephanie Berger, Erik Procko, Daciana Margineantu, Erinna F Lee, Betty W Shen, Alex Zelter, Daniel-Adriano Silva, Kusum Chawla, Marco J Herold, Jean-Marc Garnier, Richard Johnson, Michael J MacCoss, Guillaume Lessene, Trisha N Davis, Patrick S Stayton, Barry L Stoddard, W Douglas Fairlie, David M Hockenbery, David Baker
Published 2016-11-01

Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma

by Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K. Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D. Turner, A. Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Published 2021-09-01