Genome-scale chemogenomic CRISPR screens in human cells using the TKOv3 library

by Michele Olivieri, Daniel Durocher
Published 2021-03-01

A siRNA-based screen for genes involved in chromosome end protection.

by Daniel H Lackner, Daniel Durocher, Jan Karlseder
Published 2011-01-01

A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres

by Jonathan Strecker, Sonia Stinus, Mariana Pliego Caballero, Rachel K Szilard, Michael Chang, Daniel Durocher
Published 2017-08-01

ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice

by Nicole L. Batenburg, John R. Walker, Sylvie M. Noordermeer, Nathalie Moatti, Daniel Durocher, Xu-Dong Zhu
Published 2017-12-01

CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation.

by Genevieve M Vidanes, Frédéric D Sweeney, Sarah Galicia, Stephanie Cheung, John P Doyle, Daniel Durocher, David P Toczyski
Published 2010-01-01

A consensus set of genetic vulnerabilities to ATR inhibition

by Nicole Hustedt, Alejandro Álvarez-Quilón, Andrea McEwan, Jing Yi Yuan, Tiffany Cho, Lisa Koob, Traver Hart, Daniel Durocher
Published 2019-09-01

RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.

by Chantal H M A Ramaekers, Twan van den Beucken, Robert G Bristow, Roland K Chiu, Daniel Durocher, Bradly G Wouters
Published 2014-01-01

Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.

by Justin W Leung, Poonam Agarwal, Marella D Canny, Fade Gong, Aaron D Robison, Ilya J Finkelstein, Daniel Durocher, Kyle M Miller
Published 2014-03-01

Identifying chemogenetic interactions from CRISPR screens with drugZ

by Medina Colic, Gang Wang, Michal Zimmermann, Keith Mascall, Megan McLaughlin, Lori Bertolet, W. Frank Lenoir, Jason Moffat, Stephane Angers, Daniel Durocher, Traver Hart
Published 2019-08-01

A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions.

by Pamela Kanellis, Mark Gagliardi, Judit P Banath, Rachel K Szilard, Shinichiro Nakada, Sarah Galicia, Frederic D Sweeney, Diane C Cabelof, Peggy L Olive, Daniel Durocher
Published 2007-08-01

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.

by Toshiyuki Bohgaki, Miyuki Bohgaki, Renato Cardoso, Stephanie Panier, Dimphy Zeegers, Li Li, Grant S Stewart, Otto Sanchez, M Prakash Hande, Daniel Durocher, Anne Hakem, Razqallah Hakem
Published 2011-04-01

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage

by Julianne Kitevski-LeBlanc, Amélie Fradet-Turcotte, Predrag Kukic, Marcus D Wilson, Guillem Portella, Tairan Yuwen, Stephanie Panier, Shili Duan, Marella D Canny, Hugo van Ingen, Cheryl H Arrowsmith, John L Rubinstein, Michele Vendruscolo, Daniel Durocher, Lewis E Kay
Published 2017-04-01

A substrate binding model for the KEOPS tRNA modifying complex

by Jonah Beenstock, Samara Mishelle Ona, Jennifer Porat, Stephen Orlicky, Leo C. K. Wan, Derek F. Ceccarelli, Pierre Maisonneuve, Rachel K. Szilard, Zhe Yin, Dheva Setiaputra, Daniel Y. L. Mao, Morgan Khan, Shaunak Raval, David C. Schriemer, Mark A. Bayfield, Daniel Durocher, Frank Sicheri
Published 2020-12-01

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

by Traver Hart, Amy Hin Yan Tong, Katie Chan, Jolanda Van Leeuwen, Ashwin Seetharaman, Michael Aregger, Megha Chandrashekhar, Nicole Hustedt, Sahil Seth, Avery Noonan, Andrea Habsid, Olga Sizova, Lyudmila Nedyalkova, Ryan Climie, Leanne Tworzyanski, Keith Lawson, Maria Augusta Sartori, Sabriyeh Alibeh, David Tieu, Sanna Masud, Patricia Mero, Alexander Weiss, Kevin R. Brown, Matej Usaj, Maximilian Billmann, Mahfuzur Rahman, Michael Constanzo, Chad L. Myers, Brenda J. Andrews, Charles Boone, Daniel Durocher, Jason Moffat
Published 2017-08-01

Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival

by Nathaniel D. Anderson, Yael Babichev, Fabio Fuligni, Federico Comitani, Mehdi Layeghifard, Rosemarie E. Venier, Stefan C. Dentro, Anant Maheshwari, Sheena Guram, Claire Wunker, J. Drew Thompson, Kyoko E. Yuki, Huayun Hou, Matthew Zatzman, Nicholas Light, Marcus Q. Bernardini, Jay S. Wunder, Irene L. Andrulis, Peter Ferguson, Albiruni R. Abdul Razak, Carol J. Swallow, James J. Dowling, Rima S. Al-Awar, Richard Marcellus, Marjan Rouzbahman, Moritz Gerstung, Daniel Durocher, Ludmil B. Alexandrov, Brendan C. Dickson, Rebecca A. Gladdy, Adam Shlien
Published 2021-07-01