Conformational dynamics of the human serotonin transporter during substrate and drug binding

by Ingvar R. Möller, Marika Slivacka, Anne Kathrine Nielsen, Søren G. F. Rasmussen, Ulrik Gether, Claus J. Loland, Kasper D. Rand
Published 2019-04-01

Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter

by Christian B. Billesbølle, Jonas S. Mortensen, Azmat Sohail, Solveig G. Schmidt, Lei Shi, Harald H. Sitte, Ulrik Gether, Claus J. Loland
Published 2016-09-01

Substrate-induced conformational dynamics of the dopamine transporter

by Anne Kathrine Nielsen, Ingvar R. Möller, Yong Wang, Søren G. F. Rasmussen, Kresten Lindorff-Larsen, Kasper D. Rand, Claus J. Loland
Published 2019-06-01

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

by Per Plenge, Ara M. Abramyan, Gunnar Sørensen, Arne Mørk, Pia Weikop, Ulrik Gether, Benny Bang-Andersen, Lei Shi, Claus J. Loland
Published 2020-03-01

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

by Per Plenge, Dongxue Yang, Kristine Salomon, Louise Laursen, Iris E. Kalenderoglou, Amy H. Newman, Eric Gouaux, Jonathan A. Coleman, Claus J. Loland
Published 2021-08-01

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

by Simon Erlendsson, Kamil Gotfryd, Flemming Hofmann Larsen, Jonas Sigurd Mortensen, Michel-Andreas Geiger, Barth-Jan van Rossum, Hartmut Oschkinat, Ulrik Gether, Kaare Teilum, Claus J Loland
Published 2017-01-01

The Environment Shapes the Inner Vestibule of LeuT.

by Azmat Sohail, Kumaresan Jayaraman, Santhoshkannan Venkatesan, Kamil Gotfryd, Markus Daerr, Ulrik Gether, Claus J Loland, Klaus T Wanner, Michael Freissmuth, Harald H Sitte, Walter Sandtner, Thomas Stockner
Published 2016-11-01

Tandem malonate-based glucosides (TMGs) for membrane protein structural studies

by Hazrat Hussain, Jonas S. Mortensen, Yang Du, Claudia Santillan, Orquidea Ribeiro, Juyeon Go, Parameswaran Hariharan, Claus J. Loland, Lan Guan, Brian K. Kobilka, Bernadette Byrne, Pil Seok Chae
Published 2017-06-01

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

by Kamil Gotfryd, Thomas Boesen, Jonas S. Mortensen, George Khelashvili, Matthias Quick, Daniel S. Terry, Julie W. Missel, Michael V. LeVine, Pontus Gourdon, Scott C. Blanchard, Jonathan A. Javitch, Harel Weinstein, Claus J. Loland, Poul Nissen, Ulrik Gether
Published 2020-02-01