The Glu102 mutation disrupts higher-order oligomerization of the sigma 1 receptor

by Ara M. Abramyan, Hideaki Yano, Min Xu, Leanne Liu, Sett Naing, Andrew D. Fant, Lei Shi
Published 2020-01-01

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

by Per Plenge, Ara M. Abramyan, Gunnar Sørensen, Arne Mørk, Pia Weikop, Ulrik Gether, Benny Bang-Andersen, Lei Shi, Claus J. Loland
Published 2020-03-01

The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.

by Ravi Kumar Verma, Ara M Abramyan, Mayako Michino, R Benjamin Free, David R Sibley, Jonathan A Javitch, J Robert Lane, Lei Shi
Published 2018-01-01

Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism

by J Robert Lane, Ara M Abramyan, Pramisha Adhikari, Alastair C Keen, Kuo-Hao Lee, Julie Sanchez, Ravi Kumar Verma, Herman D Lim, Hideaki Yano, Jonathan A Javitch, Lei Shi
Published 2020-01-01

High-potency ligands for DREADD imaging and activation in rodents and monkeys

by Jordi Bonaventura, Mark A. G. Eldridge, Feng Hu, Juan L. Gomez, Marta Sanchez-Soto, Ara M. Abramyan, Sherry Lam, Matthew A. Boehm, Christina Ruiz, Mitchell R. Farrell, Andrea Moreno, Islam Mustafa Galal Faress, Niels Andersen, John Y. Lin, Ruin Moaddel, Patrick J. Morris, Lei Shi, David R. Sibley, Stephen V. Mahler, Sadegh Nabavi, Martin G. Pomper, Antonello Bonci, Andrew G. Horti, Barry J. Richmond, Michael Michaelides
Published 2019-10-01