The Lipid Virulence Factors of <i>Mycobacterium tuberculosis </i>Exert Multilayered Control over Autophagy-Related Pathways in Infected Human Macrophages

by Aïcha Bah, Merlin Sanicas, Jérôme Nigou, Christophe Guilhot, Catherine Astarie-Dequeker, Isabelle Vergne
Published 2020-03-01

Phthiocerol dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids.

by Catherine Astarie-Dequeker, Laurent Le Guyader, Wladimir Malaga, Fam-Ky Seaphanh, Christian Chalut, André Lopez, Christophe Guilhot
Published 2009-02-01

Functional characterisation of three o-methyltransferases involved in the biosynthesis of phenolglycolipids in Mycobacterium tuberculosis.

by Roxane Simeone, Gaëlle Huet, Patricia Constant, Wladimir Malaga, Anne Lemassu, Françoise Laval, Mamadou Daffé, Christophe Guilhot, Christian Chalut
Published 2013-01-01

4'-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo.

by Cécile Leblanc, Thomas Prudhomme, Guillaume Tabouret, Aurélie Ray, Sophie Burbaud, Stéphanie Cabantous, Lionel Mourey, Christophe Guilhot, Christian Chalut
Published 2012-12-01

The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis.

by Luis Solans, Jesús Gonzalo-Asensio, Claudia Sala, Andrej Benjak, Swapna Uplekar, Jacques Rougemont, Christophe Guilhot, Wladimir Malaga, Carlos Martín, Stewart T Cole
Published 2014-05-01

Phthiocerol Dimycocerosates From Mycobacterium tuberculosis Increase the Membrane Activity of Bacterial Effectors and Host Receptors

by Jacques Augenstreich, Evert Haanappel, Fadel Sayes, Roxane Simeone, Valérie Guillet, Serge Mazeres, Christian Chalut, Lionel Mourey, Roland Brosch, Christophe Guilhot, Catherine Astarie-Dequeker
Published 2020-08-01

Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages

by Reid Oldenburg, Reid Oldenburg, Veronique Mayau, Jacques Prandi, Ainhoa Arbues, Catherine Astarie-Dequeker, Christophe Guilhot, Catherine Werts, Nathalie Winter, Nathalie Winter, Caroline Demangel
Published 2018-01-01

Protein O-mannosylation deficiency increases LprG-associated lipoarabinomannan release by Mycobacterium tuberculosis and enhances the TLR2-associated inflammatory response

by Henar Alonso, Julien Parra, Wladimir Malaga, Delphine Payros, Chia-Fang Liu, Céline Berrone, Camille Robert, Etienne Meunier, Odile Burlet-Schiltz, Michel Rivière, Christophe Guilhot
Published 2017-08-01

Mycobacterium tuberculosis and M. bovis BCG Moreau Fumarate Reductase Operons Produce Different Polypeptides That May Be Related to Non-canonical Functions

by Marcos Gustavo Araujo Schwarz, Deborah Antunes, Paloma Rezende Corrêa, Antônio José da Silva-Gonçalves, Wladimir Malaga, Ernesto Raul Caffarena, Christophe Guilhot, Leila Mendonça-Lima
Published 2021-01-01

Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes.

by Guillaume Tabouret, Catherine Astarie-Dequeker, Caroline Demangel, Wladimir Malaga, Patricia Constant, Aurélie Ray, Nadine Honoré, Nana Fatimath Bello, Esther Perez, Mamadou Daffé, Christophe Guilhot
Published 2010-10-01

Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds

by Coralie Carivenc, Laurent Maveyraud, Claire Blanger, Stéphanie Ballereau, Coralie Roy-Camille, Minh Chau Nguyen, Yves Génisson, Christophe Guilhot, Christian Chalut, Jean-Denis Pedelacq, Lionel Mourey
Published 2021-09-01

CR3 Engaged by PGL-I Triggers Syk-Calcineurin-NFATc to Rewire the Innate Immune Response in Leprosy

by Émilie Doz-Deblauwe, Florence Carreras, Ainhoa Arbues, Aude Remot, Mathieu Epardaud, Wladimir Malaga, Véronique Mayau, Jacques Prandi, Catherine Astarie-Dequeker, Christophe Guilhot, Caroline Demangel, Nathalie Winter
Published 2019-12-01

Mycobacterium tuberculosis lineage influences innate immune response and virulence and is associated with distinct cell envelope lipid profiles.

by Nitya Krishnan, Wladimir Malaga, Patricia Constant, Maxine Caws, Thi Hoang Chau Tran, Jenifer Salmons, Thi Ngoc Lan Nguyen, Duc Bang Nguyen, Mamadou Daffé, Douglas B Young, Brian D Robertson, Christophe Guilhot, Guy E Thwaites
Published 2011-01-01

PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves.

by Chyntia Carolina Díaz Acosta, André Alves Dias, Thabatta Leal Silveira Andrezo Rosa, Leonardo Ribeiro Batista-Silva, Patricia Sammarco Rosa, Thiago Gomes Toledo-Pinto, Fabrício da Mota Ramalho Costa, Flávio Alves Lara, Luciana Silva Rodrigues, Katherine Antunes Mattos, Euzenir Nunes Sarno, Patrícia Torres Bozza, Christophe Guilhot, Márcia de Berrêdo-Pinho, Maria Cristina Vidal Pessolani
Published 2018-07-01

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development

by Stefan H. E. Kaufmann, Hazel M. Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom H. M. Ottenhoff, Brij Patel, Danielle Roordink, François Spertini, Steffen Stenger, Jelle Thole, Frank A. W. Verreck, Ann Williams, TBVAC2020 Consortium, Warwick Britton, Jamie Triccas, Claudio Counoupas, Johan Grooten, Marie-Ange Demoitie, Marta Romano, Francoise Mascart, Peter Andersen, Claus Aagaard, Dennis Christensen, Morten Ruhwald, Thomas Lindenstrom, Olivier Neyrolles, Pierre Charneau, Christophe Guilhot, Antonio Peixoto, Martine Gilleron, Camille Locht, Roland Brosch, Genevieve Inchauspe, Stephane Leung Theung Long, Stefan Kaufmann, January Weiner, Jeroen Maertzdorf, Natalie Neuwenhuizen, Max Bastian, Steffen Stenger, Nadia Caccamo, Delia Goletti, Roberto Nisini, Sung Jae Shin, Hyejon Lee, Alex Sigal, Thomas Scriba, Gerhard Walzl, Andre Loxton, Robert Wilkinson, Pere-Joan Cardona, Cris Vilaplana, Carlos Martin, Dessi Marinova, Nacho Aguilo, François Spertini, Ruedi Aebersold, Etienne Caron, Daniel Pinschewer, Gennaro De Libero, Claire Anne Siegrist, Nicolas Collin, Christophe Barnier-Quer, Peter Sander, Frank Verreck, Tom Ottenhoff, Simone Joosten, Krista van Meijgaarden, Mariateresa Coppola, Annemieke Geluk, Nick Drager, Danielle Roordink, Jelle Thole, Yvonne Perrie, Marc Baird, Michael Levin, Hazel Dockrell, Steven Smith, Helen Fletcher, Gregory Bancroft, Ann Rawkins, Simon Clark, Mei Mei Ho, Helen McShane, Iman Satti, Elena Stylianou, Martin Vordermeier, Philip Hogarth
Published 2017-10-01