Mycobacterial virulence: impact on immunogenicity and vaccine research [version 1; peer review: 4 approved]

by Vera M. Kroesen, Jan Madacki, Wafa Frigui, Fadel Sayes, Roland Brosch
Published 2019-11-01

Basophil activation through TLR2 and TLR4 signaling pathways

by Manal Alkan, Fadel Sayes, Abdulraouf Ramadan, Francois Machavoine, Michel Dy, Elke Schneider, Nathalie Thieblemont
Published 2018-08-01

Cytosolic access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo.

by Roxane Simeone, Fadel Sayes, Okryul Song, Matthias I Gröschel, Priscille Brodin, Roland Brosch, Laleh Majlessi
Published 2015-02-01

Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential

by Irene Pérez, Santiago Uranga, Fadel Sayes, Wafa Frigui, Sofía Samper, Ainhoa Arbués, Nacho Aguiló, Roland Brosch, Carlos Martín, Jesús Gonzalo-Asensio
Published 2020-05-01

Phthiocerol Dimycocerosates From Mycobacterium tuberculosis Increase the Membrane Activity of Bacterial Effectors and Host Receptors

by Jacques Augenstreich, Evert Haanappel, Fadel Sayes, Roxane Simeone, Valérie Guillet, Serge Mazeres, Christian Chalut, Lionel Mourey, Roland Brosch, Christophe Guilhot, Catherine Astarie-Dequeker
Published 2020-08-01

CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection.

by Fadel Sayes, Alexandre Pawlik, Wafa Frigui, Matthias I Gröschel, Samuel Crommelynck, Catherine Fayolle, Felipe Cia, Gregory J Bancroft, Daria Bottai, Claude Leclerc, Roland Brosch, Laleh Majlessi
Published 2016-07-01

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection.

by Louis S Ates, Fadel Sayes, Wafa Frigui, Roy Ummels, Merel P M Damen, Daria Bottai, Marcel A Behr, Jeroen W J van Heijst, Wilbert Bitter, Laleh Majlessi, Roland Brosch
Published 2018-06-01

Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

by Matthias I. Gröschel, Fadel Sayes, Sung Jae Shin, Wafa Frigui, Alexandre Pawlik, Mickael Orgeur, Robin Canetti, Nadine Honoré, Roxane Simeone, Tjip S. van der Werf, Wilbert Bitter, Sang-Nae Cho, Laleh Majlessi, Roland Brosch
Published 2017-03-01

TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages

by Daria Bottai, Wafa Frigui, Fadel Sayes, Mariagrazia Di Luca, Dalila Spadoni, Alexandre Pawlik, Marina Zoppo, Mickael Orgeur, Varun Khanna, David Hardy, Sophie Mangenot, Valerie Barbe, Claudine Medigue, Laurence Ma, Christiane Bouchier, Arianna Tavanti, Gerald Larrouy-Maumus, Roland Brosch
Published 2020-02-01

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors

by Fadel Sayes, Catherine Blanc, Louis S. Ates, Nathalie Deboosere, Mickael Orgeur, Fabien Le Chevalier, Matthias I. Gröschel, Wafa Frigui, Ok-Ryul Song, Richard Lo-Man, Florence Brossier, Wladimir Sougakoff, Daria Bottai, Priscille Brodin, Pierre Charneau, Roland Brosch, Laleh Majlessi
Published 2018-04-01