Assay optimisation and technology transfer for multi-site immuno-monitoring in vaccine trials.

by Steven G Smith, Stephanie A Harris, Iman Satti, Donna Bryan, K Barry Walker, Hazel M Dockrell, Helen McShane, Mei Mei Ho
Published 2017-01-01

Alternate aerosol and systemic immunisation with a recombinant viral vector for tuberculosis, MVA85A: A phase I randomised controlled trial.

by Zita-Rose Manjaly Thomas, Iman Satti, Julia L Marshall, Stephanie A Harris, Raquel Lopez Ramon, Ali Hamidi, Alice Minhinnick, Michael Riste, Lisa Stockdale, Alison M Lawrie, Samantha Vermaak, Morven Wilkie, Henry Bettinson, Helen McShane
Published 2019-04-01

Immunological correlates of mycobacterial growth inhibition describe a spectrum of tuberculosis infection

by Matthew K. O’Shea, Rachel Tanner, Julius Müller, Stephanie A. Harris, Danny Wright, Lisa Stockdale, Elena Stylianou, Iman Satti, Steven G. Smith, James Dunbar, Thomas E. Fletcher, Martin Dedicoat, Adam F. Cunningham, Helen McShane
Published 2018-09-01

The effect of current Schistosoma mansoni infection on the immunogenicity of a candidate TB vaccine, MVA85A, in BCG-vaccinated adolescents: An open-label trial.

by Anne Wajja, Dennison Kizito, Beatrice Nassanga, Angela Nalwoga, Joyce Kabagenyi, Simon Kimuda, Ronald Galiwango, Gertrude Mutonyi, Samantha Vermaak, Iman Satti, Jaco Verweij, Edridah Tukahebwa, Stephen Cose, Jonathan Levin, Pontiano Kaleebu, Alison M Elliott, Helen McShane
Published 2017-05-01

Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines.

by Steven G Smith, Kaatje Smits, Simone A Joosten, Krista E van Meijgaarden, Iman Satti, Helen A Fletcher, Nadia Caccamo, Francesco Dieli, Francoise Mascart, Helen McShane, Hazel M Dockrell, Tom H M Ottenhoff, TBVI TB Biomarker Working Group
Published 2015-01-01

The in vitro direct mycobacterial growth inhibition assay (MGIA) for the early evaluation of TB vaccine candidates and assessment of protective immunity: a protocol for non-human p...

by Rachel Tanner, Emily Hoogkamer, Julia Bitencourt, Andrew White, Charelle Boot, Claudia C. Sombroek, Stephanie A. Harris, Matthew K. O'Shea, Daniel Wright, Rachel Wittenberg, Charlotte Sarfas, Iman Satti, Frank A.W. Verreck, Sally A. Sharpe, Helen A. Fletcher, Helen McShane
Published 2021-03-01

Tools for Assessing the Protective Efficacy of TB Vaccines in Humans: in vitro Mycobacterial Growth Inhibition Predicts Outcome of in vivo Mycobacterial Infection

by Rachel Tanner, Iman Satti, Stephanie A. Harris, Matthew K. O'Shea, Matthew K. O'Shea, Deniz Cizmeci, Daniel O'Connor, Agnieszka Chomka, Magali Matsumiya, Rachel Wittenberg, Angela M. Minassian, Joel Meyer, Helen A. Fletcher, Helen A. Fletcher, Helen McShane
Published 2020-01-01

Lessons from the first clinical trial of a non-licensed vaccine among Ugandan adolescents: a phase II field trial of the tuberculosis candidate vaccine, MVA85A [version 1; referees...

by Anne Wajja, Milly Namutebi, Barbara Apule, Gloria Oduru, Samuel Kiwanuka, Mirriam Akello, Beatrice Nassanga, Joyce Kabagenyi, Juma Mpiima, Samantha Vermaak, Alison Lawrie, Iman Satti, Jaco Verweij, Stephen Cose, Jonathan Levin, Pontiano Kaleebu, Edridah Tukahebwa, Helen McShane, Alison M. Elliott
Published 2018-09-01

The in vitro direct mycobacterial growth inhibition assay (MGIA) for the early evaluation of TB vaccine candidates and assessment of protective immunity: a protocol for non-human p...

by Rachel Tanner, Emily Hoogkamer, Julia Bitencourt, Andrew White, Charelle Boot, Claudia C. Sombroek, Stephanie A. Harris, Matthew K. O'Shea, Daniel Wright, Rachel Wittenberg, Charlotte Sarfas, Iman Satti, Frank A.W. Verreck, Sally A. Sharpe, Helen A. Fletcher, Helen McShane
Published 2021-09-01

A non-human primate in vitro functional assay for the early evaluation of TB vaccine candidates

by Rachel Tanner, Andrew D. White, Charelle Boot, Claudia C. Sombroek, Matthew K. O’Shea, Daniel Wright, Emily Hoogkamer, Julia Bitencourt, Stephanie A. Harris, Charlotte Sarfas, Rachel Wittenberg, Iman Satti, Helen A. Fletcher, Frank A. W. Verreck, Sally A. Sharpe, Helen McShane
Published 2021-01-01

Phase I Trial Evaluating the Safety and Immunogenicity of Candidate TB Vaccine MVA85A, Delivered by Aerosol to Healthy <i>M.tb</i>-Infected Adults

by Michael Riste, Julia L. Marshall, Iman Satti, Stephanie A. Harris, Morven Wilkie, Raquel Lopez Ramon, Danny Wright, Rachel Wittenberg, Samantha Vermaak, Rebecca Powell Doherty, Alison Lawrie, Christopher P. Conlon, Catherine Cosgrove, Fergus Gleeson, Marc Lipman, Paul Moss, Felicity Perrin, Martin Dedicoat, Henry Bettinson, Helen McShane
Published 2021-04-01

A Phase I, Open-Label Trial, Evaluating the Safety and Immunogenicity of Candidate Tuberculosis Vaccines AERAS-402 and MVA85A, Administered by Prime-Boost Regime in BCG-Vaccinated...

by Sharon Sheehan, Stephanie A Harris, Iman Satti, David A Hokey, Veerabadran Dheenadhayalan, Lisa Stockdale, Zita-Rose Manjaly Thomas, Alice Minhinnick, Morven Wilkie, Samantha Vermaak, Joel Meyer, Matthew K O'Shea, Maria Grazia Pau, Isabella Versteege, Macaya Douoguih, Jenny Hendriks, Jerald Sadoff, Bernard Landry, Paul Moss, Helen McShane
Published 2015-01-01

Correction: Corrigendum: T-cell activation is an immune correlate of risk in BCG vaccinated infants

by Helen A. Fletcher, Margaret A. Snowden, Bernard Landry, Wasima Rida, Iman Satti, Stephanie A. Harris, Magali Matsumiya, Rachel Tanner, Matthew K. O’Shea, Veerabadran Dheenadhayalan, Leah Bogardus, Lisa Stockdale, Leanne Marsay, Agnieszka Chomka, Rachel Harrington-Kandt, Zita-Rose Manjaly-Thomas, Vivek Naranbhai, Elena Stylianou, Fatoumatta Darboe, Adam Penn-Nicholson, Elisa Nemes, Mark Hatherill, Gregory Hussey, Hassan Mahomed, Michele Tameris, J. Bruce McClain, Thomas G. Evans, Willem A. Hanekom, Thomas J. Scriba, Helen McShane
Published 2016-05-01

T-cell activation is an immune correlate of risk in BCG vaccinated infants

by Helen A. Fletcher, Margaret A. Snowden, Bernard Landry, Wasima Rida, Iman Satti, Stephanie A. Harris, Magali Matsumiya, Rachel Tanner, Matthew K. O’Shea, Veerabadran Dheenadhayalan, Leah Bogardus, Lisa Stockdale, Leanne Marsay, Agnieszka Chomka, Rachel Harrington-Kandt, Zita-Rose Manjaly-Thomas, Vivek Naranbhai, Elena Stylianou, Fatoumatta Darboe, Adam Penn-Nicholson, Elisa Nemes, Mark Hatherill, Gregory Hussey, Hassan Mahomed, Michele Tameris, J Bruce McClain, Thomas G. Evans, Willem A. Hanekom, Thomas J. Scriba, Helen McShane
Published 2016-04-01

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development

by Stefan H. E. Kaufmann, Hazel M. Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom H. M. Ottenhoff, Brij Patel, Danielle Roordink, François Spertini, Steffen Stenger, Jelle Thole, Frank A. W. Verreck, Ann Williams, TBVAC2020 Consortium, Warwick Britton, Jamie Triccas, Claudio Counoupas, Johan Grooten, Marie-Ange Demoitie, Marta Romano, Francoise Mascart, Peter Andersen, Claus Aagaard, Dennis Christensen, Morten Ruhwald, Thomas Lindenstrom, Olivier Neyrolles, Pierre Charneau, Christophe Guilhot, Antonio Peixoto, Martine Gilleron, Camille Locht, Roland Brosch, Genevieve Inchauspe, Stephane Leung Theung Long, Stefan Kaufmann, January Weiner, Jeroen Maertzdorf, Natalie Neuwenhuizen, Max Bastian, Steffen Stenger, Nadia Caccamo, Delia Goletti, Roberto Nisini, Sung Jae Shin, Hyejon Lee, Alex Sigal, Thomas Scriba, Gerhard Walzl, Andre Loxton, Robert Wilkinson, Pere-Joan Cardona, Cris Vilaplana, Carlos Martin, Dessi Marinova, Nacho Aguilo, François Spertini, Ruedi Aebersold, Etienne Caron, Daniel Pinschewer, Gennaro De Libero, Claire Anne Siegrist, Nicolas Collin, Christophe Barnier-Quer, Peter Sander, Frank Verreck, Tom Ottenhoff, Simone Joosten, Krista van Meijgaarden, Mariateresa Coppola, Annemieke Geluk, Nick Drager, Danielle Roordink, Jelle Thole, Yvonne Perrie, Marc Baird, Michael Levin, Hazel Dockrell, Steven Smith, Helen Fletcher, Gregory Bancroft, Ann Rawkins, Simon Clark, Mei Mei Ho, Helen McShane, Iman Satti, Elena Stylianou, Martin Vordermeier, Philip Hogarth
Published 2017-10-01