Machine learning analysis plans for randomised controlled trials: detecting treatment effect heterogeneity with strict control of type I error

by James A. Watson, Chris C. Holmes
Published 2020-02-01

Graphing and reporting heterogeneous treatment effects through reference classes

by James A. Watson, Chris C. Holmes
Published 2020-05-01

Correction to: Graphing and reporting heterogeneous treatment effects through reference classes

by James A. Watson, Chris C. Holmes
Published 2020-10-01

Key issues in conducting a meta-analysis of gene expression microarray datasets.

by Adaikalavan Ramasamy, Adrian Mondry, Chris C Holmes, Douglas G Altman
Published 2008-09-01

A novel test for gene-ancestry interactions in genome-wide association data.

by Joanna L Davies, Jean-Baptiste Cazier, Malcolm G Dunlop, Richard S Houlston, Ian P Tomlinson, Chris C Holmes
Published 2012-01-01

A cautionary note on the use of unsupervised machine learning algorithms to characterise malaria parasite population structure from genetic distance matrices.

by James A Watson, Aimee R Taylor, Elizabeth A Ashley, Arjen Dondorp, Caroline O Buckee, Nicholas J White, Chris C Holmes
Published 2020-10-01

Transcriptome Deconvolution of Heterogeneous Tumor Samples with Immune Infiltration

by Zeya Wang, Shaolong Cao, Jeffrey S. Morris, Jaeil Ahn, Rongjie Liu, Svitlana Tyekucheva, Fan Gao, Bo Li, Wei Lu, Ximing Tang, Ignacio I. Wistuba, Michaela Bowden, Lorelei Mucci, Massimo Loda, Giovanni Parmigiani, Chris C. Holmes, Wenyi Wang
Published 2018-11-01

MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven.

by Mattias Rantalainen, Blanca M Herrera, George Nicholson, Rory Bowden, Quin F Wills, Josine L Min, Matt J Neville, Amy Barrett, Maxine Allen, Nigel W Rayner, Jan Fleckner, Mark I McCarthy, Krina T Zondervan, Fredrik Karpe, Chris C Holmes, Cecilia M Lindgren
Published 2011-01-01

Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

by James A Watson, Carolyne M Ndila, Sophie Uyoga, Alexander Macharia, Gideon Nyutu, Shebe Mohammed, Caroline Ngetsa, Neema Mturi, Norbert Peshu, Benjamin Tsofa, Kirk Rockett, Stije Leopold, Hugh Kingston, Elizabeth C George, Kathryn Maitland, Nicholas PJ Day, Arjen M Dondorp, Philip Bejon, Thomas Williams, Chris C Holmes, Nicholas J White
Published 2021-07-01

Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.

by Josine L Min, George Nicholson, Ingileif Halgrimsdottir, Kristian Almstrup, Andreas Petri, Amy Barrett, Mary Travers, Nigel W Rayner, Reedik Mägi, Fredrik H Pettersson, John Broxholme, Matt J Neville, Quin F Wills, Jane Cheeseman, GIANT Consortium, MolPAGE Consortium, Maxine Allen, Chris C Holmes, Tim D Spector, Jan Fleckner, Mark I McCarthy, Fredrik Karpe, Cecilia M Lindgren, Krina T Zondervan
Published 2012-01-01

A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.

by George Nicholson, Mattias Rantalainen, Jia V Li, Anthony D Maher, Daniel Malmodin, Kourosh R Ahmadi, Johan H Faber, Amy Barrett, Josine L Min, N William Rayner, Henrik Toft, Maria Krestyaninova, Juris Viksna, Sudeshna Guha Neogi, Marc-Emmanuel Dumas, Ugis Sarkans, MolPAGE Consortium, Peter Donnelly, Thomas Illig, Jerzy Adamski, Karsten Suhre, Maxine Allen, Krina T Zondervan, Tim D Spector, Jeremy K Nicholson, John C Lindon, Dorrit Baunsgaard, Elaine Holmes, Mark I McCarthy, Chris C Holmes
Published 2011-09-01